Comparative hydrology has been hampered by limited availability of geographically extensive, intercompatible monitoring data on comprehensive water balance stores and fluxes. These limitations have, for example, restricted comprehensive assessment of multiple dimensions of wetting and drying related to climate change and hampered understanding of why widespread changes in precipitation extremes are uncorrelated with changes in streamflow extremes. Here, we address this knowledge gap and underlying data gap by developing a new data synthesis product and using that product to detect trends in the frequencies and magnitudes of a comprehensive set of hydroclimatic and hydrologic extremes. CHOSEN (Comprehensive Hydrologic Observatory Sensor Network) is a database of streamflow, soil moisture, and other hydroclimatic and hydrologic variables from 30 study areas across the United States. An accompanying data pipeline provides a reproducible, semi-automated approach for assimilating data from multiple sources, performing quality assurance and control, gap-filling and writing to a standard format. Based on the analysis of extreme events in the CHOSEN dataset, we detected hotspots, characterized by unusually large proportions of monitored variables exhibiting trends, in the Pacific Northwest, New England, Florida and Alaska. Extreme streamflow wetting and drying trends exhibited regional coherence. Drying trends in the Pacific Northwest and Southeast were often associated with trends in soil moisture and precipitation (Pacific Northwest) and evapotranspiration-related variables (Southeast). In contrast, wetting trends in the upper Midwest and the Rocky Mountains showed few univariate associations with other hydroclimatic extremes, but their latitudes and elevations suggested the importance of changing snowmelt characteristics. On the whole, observed trends are incompatible with a 'drying-in-dry, wetting-in-wet' paradigm for climate-induced hydrologic changes over land. Our analysis underscores the need for more extensive, longer-term observational data for soil moisture, snow and evapotranspiration.