The combination of Alisma and Atractylodes ameliorates cerebral ischaemia/reperfusion injury by negatively regulating astrocyte-derived exosomal miR-200a-3p/141-3p by targeting SIRT1

Exosomes-Mediated Signaling Pathway: A New Direction for Treatment of Organ Ischemia-Reperfusion Injury

“…Chinese herbal decoction can also affect the NF-κB pathway and improve cerebral ischemia-reperfusion injury. For example, atractylodes macrocephala inhibits the uptake of miRNA-200a-3p by astrocyte-derived exosomes, thereby enhancing the expression of sirtuin1 (SIRT1) in the cerebral cortex, binding to the p65 subunit of NF-κB and attenuating the inflammatory response in brain I/R injury [48].…”

The Role of microRNAs in Epigenetic Regulation of Signaling Pathways in Neurological Pathologies

“…Similar effects are observed with the inhibition of miR-19a-3p, which reduces the extent and area of cerebral ischemia–reperfusion injury by regulating inflammation and apoptosis through increased expression of IGFBP3 both in vivo and in vitro [ 106 ]. It has also been discovered that inhibiting exosomal miR-200a-3p/141-3p, which originates from astrocytes and targets the gene SIRT1 and its associated signaling pathways, reduces the pathological consequences of cerebral ischemia–reperfusion injury in a mouse model [ 107 ]. MiR-370 has been shown to exacerbate neuronal reperfusion injury by impacting the expression of SIRT6 and the regulation mechanism of the Nrf2/ARE signaling pathway [ 108 ], while the exosomal form of this microRNA (370-3p) increases blood–brain barrier permeability during ischemia–reperfusion injury through the interference of MAPK1 [ 109 ].…”

“…Most studies from various researchers have demonstrated unidirectional effectiveness regarding the neuroprotective role of miR-10b-3p [ 116 , 117 ], miR-124-3p [ 119 , 120 ], miR-141-3p [ 107 , 131 ], miR-153-3p [ 141 , 142 ], miR-182-5p [ 101 , 150 ], miR-20a-3p [ 162 , 163 ], miR-22-3p [ 171 , 172 ], miR-24-3p [ 175 , 176 ], miR-27a-3p [ 181 , 182 , 183 ], miR-342-5p [ 191 , 192 ], miR-455-3p [ 200 , 201 ], miR-488-3p [ 203 , 204 ], and miR-92b-3p [ 100 , 221 ] as well as the damaging role of miR-141-3p [ 107 , 131 ], miR-155-5p [ 111 , 112 ], and miR-182 [ 148 , 149 ]. Therefore, these specific microRNAs should be considered as priority targets for further translation into clinical practice.…”

TXNIP/NLRP3 aggravates global cerebral ischemia-reperfusion injury-induced cognitive decline in mice

“…Global cerebral ischemia-reperfusion (GCI/R) injury is a severe clinical condition frequently observed during events such as cardiac arrest, hemorrhagic shock, severe trauma, cardiopulmonary bypass, carotid endarterectomy, and neurosurgery [ 1 , 2 ]. This type of injury can result in learning and memory loss and may even lead to patient deaths in the days and months following reperfusion [ 3 , 4 ]. Furthermore, early cognitive impairment induced by GCI/R injury could potentially elevate the morbidity of vascular dementia and Alzheimer's disease [ 5 , 6 ].…”