The combination of antimicrobial photocatalysis and antimicrobial photodynamic therapy to eradicate the extensively drug-resistant colistin resistant Acinetobacter baumannii

Boluki, Ebrahim; Pourhajibagher, Maryam; Bahador, Abbas

doi:10.1016/j.pdpdt.2020.101816

Cited by 21 publications

(14 citation statements)

References 45 publications

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“…Considering the lack of cytotoxicity observed in vitro and the hypothesis that a photo-controlled CUR release would be effective for photoinactivation of Gram-positive (MRSA) and Gram-negative ( P. aeruginosa ) bacteria and yeast ( C. albicans ), we used CUR-loaded PRP micelles as a PS for aPDT. Importantly, UVA (369 nm) irradiation alone used for CUR photorelease did not result in antimicrobial effect against the species evaluated, which agrees with previous studies ( Wang et al, 2019 ; Boluki et al, 2020 ). UVA light reduced the viability of resistant Acinetobacter baumannii (19.2 J/cm 2 ) ( Boluki et al, 2020 ) and Escherichia coli (370 J/m 3 ) ( Wang et al, 2019 ) by only 3.01% and 0.5 lg, respectively.…”

Section: Discussionsupporting

confidence: 91%

“…Importantly, UVA (369 nm) irradiation alone used for CUR photorelease did not result in antimicrobial effect against the species evaluated, which agrees with previous studies ( Wang et al, 2019 ; Boluki et al, 2020 ). UVA light reduced the viability of resistant Acinetobacter baumannii (19.2 J/cm 2 ) ( Boluki et al, 2020 ) and Escherichia coli (370 J/m 3 ) ( Wang et al, 2019 ) by only 3.01% and 0.5 lg, respectively. Moreover, UVD (100–200 nm) and UVC (200–275 nm) showed higher antibacterial effect than UVA ( Wang et al, 2019 ).…”

Section: Discussionsupporting

confidence: 91%

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Photo-responsive polymeric micelles for the light-triggered release of curcumin targeting antimicrobial activity

et al. 2023

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Nanocarriers have been successfully used to solubilize, deliver, and increase the bioavailability of curcumin (CUR), but slow CUR release rates hinder its use as a topical photosensitizer in antimicrobial photodynamic therapy. A photo-responsive polymer (PRP) was designed for the light-triggered release of CUR with an effective light activation-dependent antimicrobial response. The characterization of the PRP was compared with non-responsive micelles comprising Pluronics™ P123 and F127. According to the findings, the PRP formed photo-responsive micelles in the nanometric scale (< 100 nm) with a lower critical micelle concentration (3.74 × 10−4 M−1, 5.8 × 10−4 M−1, and 7.2 × 10−6 M−1 for PRP, F127, P123, respectively, at 25°C) and higher entrapment efficiency of CUR (88.7, 77.2, and 72.3% for PRP, F127, and P123 micelles, respectively) than the pluronics evaluated. The PRP provided enhanced protection of CUR compared to P123 micelles, as demonstrated in fluorescence quenching studies. The light-triggered release of CUR from PRP occurred with UV light irradiation (at 355 nm and 25 mW cm−2) and a cumulative release of 88.34% of CUR within 1 h compared to 80% from pluronics after 36 h. In vitro studies showed that CUR-loaded PRP was non-toxic to mammal cell, showed inactivation of the pathogenic microorganisms Candida albicans, Pseudomonas aeruginosa, and methicillin-resistant Staphylococcus aureus, and decreased biofilm biomass when associated with blue light (455 nm, 33.84 J/cm2). The findings show that the CUR-loaded PRP micelle is a viable option for antimicrobial activity.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Photo-responsive polymeric micelles for the light-triggered release of curcumin targeting antimicrobial activity

et al. 2023

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“…One of the new technologies that have recently been used to kill microorganisms in the air is the photocatalyst technique (Moshfegh, Khosraviani, Moghaddasi, Limoodi, & Boluki, 2021). Photocatalysis has recently emerged as an effective green solution for antimicrobial disinfection applications (Boluki, Pourhajibagher, & Bahador, 2020;Ganguly, Byrne, Breen, & Pillai, 2018). Utilizing air purification systems based on photocatalyst method can easily disrupt the transmission chain of this virus through the air.…”

Section: Novel Treatment Strategiesmentioning

confidence: 99%

Therapeutic and Diagnostic Approaches for SARS-CoV-2

Moshfegh¹,

Ezzati²,

Ezzati³

et al. 2021

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Epidemic control of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infections is becoming a global health crisis and diagnostic testing to identify infected persons is indispensable. Although various aspects of the virus are still unknown to the public, early diagnosis, lockdown, and supportive care are required to treat patients. This paper reviews the literature on available information about the diagnostic method with greater emphasis on next-generation sequencing (NGS) technology and a novel therapeutic approach to

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“…In addition, in an acidic environment or microenvironment such as that found in caries-prone patients at specific sites in the mouth, ZnO NPs dissociate to produce divalent zinc ions, which themselves have been shown to be antimicrobial [ 39 ]. While most studies have applied UV light to induce a photodynamic response [ 40 , 41 , 42 , 43 , 44 ], there has also been some success in applying light to ZnO NPs via blue light-emitting diodes (LEDs) [ 45 ]. This latter approach is particularly appealing due to the low operation cost, ease of use, and compact size and portability of blue LED sources in dentistry; these are readily available in all dental practices as a portable light curing device.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Physicochemical, Mechanical, and Photocatalytic Antibacterial Properties of a Methacrylate-Based Dental Material Loaded with ZnO Nanoparticles

et al. 2022

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While resin-based materials meet the many requirements of a restorative material, they lack adequate, long-lasting antimicrobial power. This study investigated a zinc oxide nanoparticle (ZnO NP)-loaded resin-blend (RB) toward a new antimicrobial photodynamic therapy (aPDT)-based approach for managing dental caries. The results confirmed that up to 20 wt% ZnO NPs could be added without compromising the degree of conversion (DC) of the original blend. The DC achieved for the 20 wt% ZnO NP blend has been the highest reported. The effects on flexural strength (FS), shear bond strength to dentin (SBS), water sorption (WS), solubility (SL), and viability of Streptococcus mutans under 1.35 J/cm2 blue light or dark conditions were limited to ≤20 wt% ZnO NP loading. The addition of up to 20 wt% ZnO NPs had a minimal impact on FS or SBS, while a reduction in the bacteria count was observed. The maximum loading resulted in an increase in SL. Furthermore, 28-day aging in 37 °C water increased the FS for all groups, while it sustained the reduction in bacteria count for the 20 wt% resin blends. Overall, the ZnO NP-loaded resin-based restorative material presents significant potential for use in aPDT.

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The combination of antimicrobial photocatalysis and antimicrobial photodynamic therapy to eradicate the extensively drug-resistant colistin resistant Acinetobacter baumannii

Cited by 21 publications

References 45 publications

Photo-responsive polymeric micelles for the light-triggered release of curcumin targeting antimicrobial activity

Photo-responsive polymeric micelles for the light-triggered release of curcumin targeting antimicrobial activity

Therapeutic and Diagnostic Approaches for SARS-CoV-2

Exploring the Physicochemical, Mechanical, and Photocatalytic Antibacterial Properties of a Methacrylate-Based Dental Material Loaded with ZnO Nanoparticles

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