The combination of eddy thermal effect of biodegradable magnesium with immune checkpoint blockade shows enhanced efficacy against osteosarcoma

Ge, Jun; Yang, Nailin; Yang, Yuqi; Yu, Hao; Yang, Xiaocui; Wang, Yingjie; Wang, Tianyi; Cheng, Shuning; Wang, Yuanjie; Han, Zhihui; Teng, Yun; Zou, Jun; Yang, Huilin; Cheng, Liang

doi:10.1016/j.bioactmat.2023.01.008

Cited by 15 publications

(8 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Firstly, as we discussed nanoparticles (Nps) can be used for the temporal and spatial regulation or modulation of Tregs, TAMs, and MDSCs in the OS-TME. Nps offers a strategy to transform “cold” OS-TME into “hot” OS-TME, enhancing the immune response within the tumor microenvironment [ 181 ]. Secondly, the nanoparticle-based therapy regenerates the dying OS and causes immunogenic cell death (ICD) effects.…”

Section: Other Nanoparticle Effectsmentioning

confidence: 99%

Immunotherapy Innovations in the Fight against Osteosarcoma: Emerging Strategies and Promising Progress

Cheng,

Wang,

Kang

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

Immunosuppressive elements within the tumor microenvironment are the primary drivers of tumorigenesis and malignant advancement. The presence, as well as the crosstalk between myeloid-derived suppressor cells (MDSCs), osteosarcoma-associated macrophages (OS-Ms), regulatory T cells (Tregs), and endothelial cells (ECs) with osteosarcoma cells cause the poor prognosis of OS. In addition, the consequent immunosuppressive factors favor the loss of treatment potential. Nanoparticles offer a means to dynamically and locally manipulate immuno-nanoparticles, which present a promising strategy for transforming OS-TME. Additionally, chimeric antigen receptor (CAR) technology is effective in combating OS. This review summarizes the essential mechanisms of immunosuppressive cells in the OS-TME and the current immune-associated strategies. The last part highlights the limitations of existing therapies and offers insights into future research directions.

show abstract

Section: Other Nanoparticle Effectsmentioning

confidence: 99%

Immunotherapy Innovations in the Fight against Osteosarcoma: Emerging Strategies and Promising Progress

Cheng,

Wang,

Kang

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…Hyperthermic therapy (HT) refers to heating tissues to 39–45 °C, which induces endoplasmic reticulum stress through unfolded protein responses, upregulates heat shock proteins on a cell membrane surface, and releases TAAs, causing tumor ICD [ 71 , 72 ]. Photothermal therapy (PTT) is one type of HT, which means that a laser irradiates a tumor area, effectively converting light energy into heat energy through photothermal conversion agents [ 73 ].…”

Section: Hyperthermia Therapymentioning

confidence: 99%

Nanotechnology-Assisted Immunogenic Cell Death for Effective Cancer Immunotherapy

Guo,

Ma,

Zhang

et al. 2023

Vaccines

View full text Add to dashboard Cite

Tumor vaccines have been used to treat cancer. How to efficiently induce tumor-associated antigens (TAAs) secretion with host immune system activation is a key issue in achieving high antitumor immunity. Immunogenic cell death (ICD) is a process in which tumor cells upon an external stimulus change from non-immunogenic to immunogenic, leading to enhanced antitumor immune responses. The immune properties of ICD are damage-associated molecular patterns and TAA secretion, which can further promote dendritic cell maturation and antigen presentation to T cells for adaptive immune response provocation. In this review, we mainly summarize the latest studies focusing on nanotechnology-mediated ICD for effective cancer immunotherapy as well as point out the challenges.

show abstract

“…Recent studies have demonstrated the potential of inducing pyroptosis in tumor cells to enhance the infiltration of cytotoxic T lymphocytes (CTLs) and trigger a systemic immune response. , Among the various strategies for inducing pyroptosis, metal ion-overload-mediated pyroptosis is particularly favored due to its strong immunogenicity. Several metal ions, including Na + , K + , Zn 2+ , Bi 3+ , and Ca 2+ have been proven to trigger cell pyroptosis and elicit inflammatory responses. − In particular, due to the distinct messenger role of Ca 2+ , manipulating Ca 2+ overload in cancer cells can induce potent pyroptosis, resulting in a large amount of tumor-associated antigens and stimulating immune responses. , Hence, Ca 2+ is considered as an optimal candidate for inducing pyroptosis and enhancing immunotherapy . However, the intrinsic calcium buffering system of cancer cells strictly adjusts the abnormal distribution of Ca 2+ to maintain physiological Ca homeostasis, which significantly impedes the occurrence of calcium overload-induced pyroptosis and the activation of the adaptive immune system. , Additionally, the effectiveness of the adaptive immune response triggered by pyroptosis strongly depends on the activation level of antigen-presenting cells, specifically tumor-infiltrating dendritic cells (TIDCs).…”

Section: Introductionmentioning

confidence: 99%

Gas-Amplified Metalloimmunotherapy with Dual Activation of Pyroptosis and the STING Pathway for Remodeling the Immunosuppressive Cervical Cancer Microenvironment

Liu,

Lei,

Hou

et al. 2024

ACS Nano

Self Cite

View full text Add to dashboard Cite

The immunosuppressive microenvironment of cervical cancer significantly hampers the effectiveness of immunotherapy. Herein, PEGylated manganese-doped calcium sulfide nanoparticles (MCSP) were developed to effectively enhance the antitumor immune response of the cervical cancer through gas-amplified metalloimmunotherapy with dual activation of pyroptosis and STING pathway. The bioactive MCSP exhibited the ability to rapidly release Ca 2+ , Mn 2+ , and H 2 S in response to the tumor microenvironment. H 2 S disrupted the calcium buffer system of cancer cells by interfering with the oxidative phosphorylation pathway, leading to calcium overload-triggered pyroptosis. On the other hand, H 2 S-mediated mitochondrial dysfunction further promoted the release of mitochondrial DNA (mtDNA), enhancing the activation effect of Mn 2+ on the cGAS-STING signaling axis and thereby activating immunosuppressed dendritic cells. The released H 2 S acted as an important synergist between Mn 2+ and Ca 2+ by modulating dual signaling mechanisms to bridge innate and adaptive immune responses. The combination of MCSP NPs and PD-1 immunotherapy achieved synergistic antitumor effects and effectively inhibited tumor growth. This study reveals the potential collaboration between H 2 S gas therapy and metalloimmunotherapy and provides an idea for the design of nanoimmunomodulators for rational regulation of the immunosuppressive tumor microenvironment.

show abstract

The combination of eddy thermal effect of biodegradable magnesium with immune checkpoint blockade shows enhanced efficacy against osteosarcoma

Cited by 15 publications

References 59 publications

Immunotherapy Innovations in the Fight against Osteosarcoma: Emerging Strategies and Promising Progress

Immunotherapy Innovations in the Fight against Osteosarcoma: Emerging Strategies and Promising Progress

Nanotechnology-Assisted Immunogenic Cell Death for Effective Cancer Immunotherapy

Gas-Amplified Metalloimmunotherapy with Dual Activation of Pyroptosis and the STING Pathway for Remodeling the Immunosuppressive Cervical Cancer Microenvironment

Contact Info

Product

Resources

About