The Combination of Haloperidol, Dexamethasone, and Ondansetron for Prevention of Postoperative Nausea and Vomiting in Laparoscopic Sleeve Gastrectomy: a Randomized Double-Blind Trial

Benevides, Márcio Luiz; Oliveira, Sérgio Souza; Aguilar-Nascimento, José Eduardo de

doi:10.1007/s11695-013-0923-1

Cited by 57 publications

(27 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Droperidol significantly reduced nausea when compared with the other medications and placebo [67]. The triple combination of haloperidol, dexamethasone and ondansetron has been shown to decrease the incidence of PONV at two, 12 and 24 h postoperatively when compared to patients given ondansetron or the combination of ondansetron and dexamethasone [68]. Haloperidol has also been shown to improve nausea in palliative care when the nausea is related to malignant bowel obstruction [69].…”

Section: Therapeutic Usesmentioning

confidence: 99%

Safety and efficacy of commonly used antiemetics

Hendren

Aponte-Feliciano

Kovac³

2015

Expert Opinion on Drug Metabolism & Toxicology

View full text Add to dashboard Cite

The key to providing relief for patients suffering from nausea and vomiting is to consider multiple drugs to approach the nausea in a systematic way. Anesthesiologists identify patients who are at high risk of nausea and vomiting based on physical characteristics and surgical procedures. Oncologists treat nausea based on the prescribed chemotherapeutics regimen and known risk of emesis while palliative care physicians and others balance the etiology of the nausea while optimizing patients other co morbid conditions.

show abstract

Section: Therapeutic Usesmentioning

confidence: 99%

Safety and efficacy of commonly used antiemetics

Hendren

Aponte-Feliciano

Kovac³

2015

Expert Opinion on Drug Metabolism & Toxicology

View full text Add to dashboard Cite

show abstract

“…This probably reflects the improved education of the HMSM anesthetic team, which for many years has been accompanying and implanting the ACERTO Project in Brazil. Many of the anesthesiologists in this group are authors of chapters and scientific articles in national and international journals 19,20 . However, there was still a preference of surgeons for the combination of 5% glucose and saline.…”

Section: Discussionmentioning

confidence: 99%

Cuidados perioperatórios em cirurgia bariátrica no contexto do projeto ACERTO: realidade e o imaginário de cirurgiões em um hospital de Cuiabá

De-Marchi

De-Souza

Salomão

et al. 2017

Rev. Col. Bras. Cir.

View full text Add to dashboard Cite

RESUMO Objetivo: verificar o grau de conhecimento entre cirurgiões, sobre as recomendações do Projeto ACERTO em cirurgia bariátrica, correlacionando o "imaginário", sobre suas prescrições, e a "realidade", através de dados de prontuários de seus pacientes. Métodos: estudo observacional longitudinal prospectivo comparativo entre o "imaginário" dos cirurgiões, obtido através de respostas de questionário sobre condutas recomendadas pelo ACERTO e a análise de dados clínicos "reais" encontrados em prontuários de pacientes submetidos à cirurgia bariátrica. Foram analisados: jejum pré-operatório, realimentação precoce, hidratação venosa perioperatória, antibioticoprofilaxia, uso de sondas e drenos, analgesia e profilaxia de náuseas e vômitos. Foram confrontadas as respostas de sete cirurgiões e dados de 200 prontuários médicos. Resultados: todos os cirurgiões entrevistados conheciam o Projeto ACERTO. Cinco (72%) responderam que seguiam o protocolo completamente. O tempo mediano de jejum pré-operatório foi maior do que o relatado pelos cirurgiões (p<0,05). Os pacientes receberam realimentação precoce em 96,5% dos casos. O volume mediano de fluidos prescritos nas primeiras 24 horas foi 4000ml, condizente com a entrevista. Em relação à antibioticoprofilaxia, uso de sondas e drenos, analgesia e prevenção de náuseas e vômitos, não houve diferença entre o respondido e o constatado nos prontuários. Conclusão: o Projeto ACERTO era bem praticado entre os cirurgiões pesquisados, havendo boa correlação entre o "imaginário" e "realidade" dos cuidados perioperatórios prescritos em pacientes submetidos à cirurgia bariátrica.

show abstract

“…Cases of retching and vomiting were merged for statistics and calculations. If a patient experienced vomiting or intolerable nausea or requested rescue anti-emetics, 30 mg dimenhydrinate and/or 10 mg metoclopramide was administered as a rescue antiemetic [13].…”

Section: Postoperative Analgesia Managementmentioning

confidence: 99%

“…A two-drug combination, such as a double prophylaxis with ondansetron and dexamethasone, has been demonstrated to be more effective than use of only one drug in preventing PONV [9][10][11]. However, limited studies have focused on triple prophylaxis for PONV [12,13], and to our knowledge, whether addition of haloperidol to ondansetron and dexamethasone may improve therapeutic efficacy has thus far remained unclear. On one hand, the cost-benefit should be considered in the application of multiple drugs [14].…”

Section: Introductionmentioning

confidence: 99%

Addition of haloperidol to ondansetron and dexamethasone to prevent postoperative nausea and vomiting in female smoking patients following laparoscopic surgery: A prospective, randomized, double-blind study

Zhuang¹,

Yang²,

Lu³

et al. 2019

Preprint

View full text Add to dashboard Cite

Background Postoperative nausea and vomiting (PONV) is an unpleasant experience that impacts on patient comfort and satisfaction and may lead to other complications. Some risk factors such as female gender and non-smoking status were used to predict the risk of PONV. Regarding its prevention, the combination of two different types of prophylaxis has been demonstrated to exert an additive effect. The present study aimed to evaluate the efficacy of a triple combination of haloperidol, ondansetron and dexamethasone for the prevention of PONV following laparoscopic gynecological surgery in female smoking patients. Methods A total of 210 eligible consecutive female patients ranked as American Society of Anesthesiology physical status I-II and aged 18-60 years who were undergoing selective laparoscopic gynecological surgery were included in the current study and allocated into three groups: Patients in group O received 4 mg ondansetron, group OD received 4 mg ondansetron and 8 mg dexamethasone, group ODH received 4 mg ondansetron, 8 mg dexamethasone and 2 mg haloperidol intravenously prior to anesthesia induction. The incidence of PONV, the need for rescue antiemetics, pain score, patient-controlled analgesia (PCA) consumption, rescue analgesics and adverse events were recorded 48 h after operation. Results The final analysis consisted of 193 patients who completed the study. Results indicated that the incidence of PONV was significantly decreased in groups OD (20.00%) and ODH (15.63%) compared with in group O (42.19%; P = 0.005). Furthermore, the need for rescue antiemetics was significantly lower in groups OD (13.85%) and ODH (12.50%) than in group O (32.81%; P = 0.005). There was no significant difference in the incidence of PONV or the need for rescue antiemetics between groups OD and ODH (P = 0.516 and 0.821 respectively). No statistically significant differences were detected in pain score, PCA consumption, rescue analgesics or adverse events among the groups (all P > 0.05). Conclusion The addition of haloperidol to a combination of ondansetron and dexamethasone did not decrease PONV frequency below that obtained with the two-drug combination. As for female smokers, prophylaxis comprising ondansetron and dexamethasone, with or without haloperidol, could effectively reduce PONV following laparoscopic surgery.

show abstract

The Combination of Haloperidol, Dexamethasone, and Ondansetron for Prevention of Postoperative Nausea and Vomiting in Laparoscopic Sleeve Gastrectomy: a Randomized Double-Blind Trial

Abstract: The combination of haloperidol, dexamethasone, and ondansetron reduced PONV and the necessity of rescue antiemetics and also reduced morphine consumption and the volume of fluids infused postoperatively.

Cited by 57 publications

References 30 publications

Safety and efficacy of commonly used antiemetics

Safety and efficacy of commonly used antiemetics

Cuidados perioperatórios em cirurgia bariátrica no contexto do projeto ACERTO: realidade e o imaginário de cirurgiões em um hospital de Cuiabá

Addition of haloperidol to ondansetron and dexamethasone to prevent postoperative nausea and vomiting in female smoking patients following laparoscopic surgery: A prospective, randomized, double-blind study

Contact Info

Product

Resources

About