The combination of multi-functional ingredients-loaded hydrogels and three-dimensional printed porous titanium alloys for infective bone defect treatment

Qiao, Shuqing; Wu, Dehai; Li, Zuhao; Zhu, Yu; Zhan, Fei; Lai, Heng; Gu, Yun

doi:10.1177/2041731420965797

Cited by 55 publications

(31 citation statements)

References 64 publications

(68 reference statements)

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“…Many experiments have been performed in various fields, such as tissue engineering, to determine the antibacterial effects of nonantibiotic materials [7][8][9]. One of the nonantibiotic materials with antibacterial activity is a natural product.…”

Section: Introductionmentioning

confidence: 99%

Selenium Nanoparticles as Candidates for Antibacterial Substitutes and Supplements against Multidrug-Resistant Bacteria

et al. 2021

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In recent years, multidrug-resistant (MDR) bacteria have increased rapidly, representing a major threat to human health. This problem has created an urgent need to identify alternatives for the treatment of MDR bacteria. The aim of this study was to identify the antibacterial activity of selenium nanoparticles (SeNPs) and selenium nanowires (SeNWs) against MDR bacteria and assess the potential synergistic effects when combined with a conventional antibiotic (linezolid). SeNPs and SeNWs were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), zeta potential, and UV-visible analysis. The antibacterial effects of SeNPs and SeNWs were confirmed by the macro-dilution minimum inhibitory concentration (MIC) test. SeNPs showed MIC values against methicillin-sensitive S. aureus (MSSA), methicillin-resistant S. aureus (MRSA), vancomycin-resistant S. aureus (VRSA), and vancomycin-resistant enterococci (VRE) at concentrations of 20, 80, 320, and >320 μg/mL, respectively. On the other hand, SeNWs showed a MIC value of >320 μg/mL against all tested bacteria. Therefore, MSSA, MRSA, and VRSA were selected for the bacteria to be tested, and SeNPs were selected as the antimicrobial agent for the following experiments. In the time-kill assay, SeNPs at a concentration of 4X MIC (80 and 320 μg/mL) showed bactericidal effects against MSSA and MRSA, respectively. At a concentration of 2X MIC (40 and 160 μg/mL), SeNPs showed bacteriostatic effects against MSSA and bactericidal effects against MRSA, respectively. In the synergy test, SeNPs showed a synergistic effect with linezolid (LZD) through protein degradation against MSSA and MRSA. In conclusion, these results suggest that SeNPs can be candidates for antibacterial substitutes and supplements against MDR bacteria for topical use, such as dressings. However, for use in clinical situations, additional experiments such as toxicity and synergistic mechanism tests of SeNPs are needed.

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Section: Introductionmentioning

confidence: 99%

Selenium Nanoparticles as Candidates for Antibacterial Substitutes and Supplements against Multidrug-Resistant Bacteria

et al. 2021

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“…As a representation, 3D printing manufacturing technology is applied to prepare porous biocompatible scaffolds with excellent mechanical and bone conduction properties (Bittner et al, 2019;Diloksumpan et al, 2020;Polley et al, 2020). Qiao et al (2020) demonstrated a multifunctional hydrogel scaffold from supramolecular assembly of sodium tetraborate (Na 2 B 4 O 7 ), polyvinyl alcohol (PVA), Ag NPs, and tetraethyl orthosilicate (TEOS). These 3D composite scaffolds with suitable pore size and matched bone porosity exhibited good antibacterial and biological activity, which promoted BMSC proliferation and osteogenic differentiation and inhibited bacteria.…”

Section: Advances In Tissue-engineered Bone Technologymentioning

confidence: 99%

Recent Trends in the Development of Bone Regenerative Biomaterials

Tang

Liu

et al. 2021

Front. Cell Dev. Biol.

130

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The goal of a biomaterial is to support the bone tissue regeneration process at the defect site and eventually degrade in situ and get replaced with the newly generated bone tissue. Biomaterials that enhance bone regeneration have a wealth of potential clinical applications from the treatment of non-union fractures to spinal fusion. The use of bone regenerative biomaterials from bioceramics and polymeric components to support bone cell and tissue growth is a longstanding area of interest. Recently, various forms of bone repair materials such as hydrogel, nanofiber scaffolds, and 3D printing composite scaffolds are emerging. Current challenges include the engineering of biomaterials that can match both the mechanical and biological context of bone tissue matrix and support the vascularization of large tissue constructs. Biomaterials with new levels of biofunctionality that attempt to recreate nanoscale topographical, biofactor, and gene delivery cues from the extracellular environment are emerging as interesting candidate bone regenerative biomaterials. This review has been sculptured around a case-by-case basis of current research that is being undertaken in the field of bone regeneration engineering. We will highlight the current progress in the development of physicochemical properties and applications of bone defect repair materials and their perspectives in bone regeneration.

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“…Qiao et al ( 72 ) proposed a three-dimensional printed porous titanium alloy (Ti 6 Al 4 V) embedded in an antibacterial hydrogel to prevent infections. The porous structure made the implant more compatible with host bone tissue, as it avoided stress-shielding and osteolysis.…”

Section: Role Of Metallic Biomaterials In Orthopedics and Dentistrymentioning

confidence: 99%

Biomaterials for bone regeneration: an orthopedic and dentistry overview

Girón

Kerstner

Medeiros

et al. 2021

Braz J Med Biol Res

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Because bone-associated diseases are increasing, a variety of tissue engineering approaches with bone regeneration purposes have been proposed over the last years. Bone tissue provides a number of important physiological and structural functions in the human body, being essential for hematopoietic maintenance and for providing support and protection of vital organs. Therefore, efforts to develop the ideal scaffold which is able to guide the bone regeneration processes is a relevant target for tissue engineering researchers. Several techniques have been used for scaffolding approaches, such as diverse types of biomaterials. On the other hand, metallic biomaterials are widely used as support devices in dentistry and orthopedics, constituting an important complement for the scaffolds. Hence, the aim of this review is to provide an overview of the degradable biomaterials and metal biomaterials proposed for bone regeneration in the orthopedic and dentistry fields in the last years.

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The combination of multi-functional ingredients-loaded hydrogels and three-dimensional printed porous titanium alloys for infective bone defect treatment

Cited by 55 publications

References 64 publications

Selenium Nanoparticles as Candidates for Antibacterial Substitutes and Supplements against Multidrug-Resistant Bacteria

Selenium Nanoparticles as Candidates for Antibacterial Substitutes and Supplements against Multidrug-Resistant Bacteria

Recent Trends in the Development of Bone Regenerative Biomaterials

Biomaterials for bone regeneration: an orthopedic and dentistry overview

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