The combined analgesic, sedative, and anti-gastric cancer mechanisms of Tinospora sagittata var. yunnanensis (S. Y. Hu) H. S. Lo based on integrated ethnopharmacological data

Wang, Qianqian; Sun, Qin-Rong; Ji, Xin-ye; Tang, Yun; Zhang, Ke; Wang, Xiaoqin; Li, Hongrui; Huang, Xiang‐Zhong; Zhang, Bo

doi:10.1016/j.jep.2022.115990

Cited by 6 publications

(6 citation statements)

References 35 publications

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“…At this stage, one should notice that photophysical parameters measured for derivative TzTz-TPA2 differ slightly from those reported elsewhere. 25 Second, the solvent effect was investigated in detail for compound TzTz-PbtCz2 (see Figure 2). See Table 1 for photophysical data.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Nevertheless, no spectral change in terms of emission band profile and energetics are observed, as depicted in Figure S11, in sharp contrast to what was previously observed for the related compound TzTz-TPA2. 25 The emission may be ascribed to residual, unprotonated, and emitter molecules in solution.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…The compounds feature two peripheral (substituted) carbazole (Cz) units as the electron−donor groups and display intense sky-blue luminescence arising from an intramolecular chargetransfer (ICT) excited state. Compared to the previously reported TzTz-TPA2 parental derivative, 25 which has been used as a benchmark and emits green in thin films and solid states, the newly proposed emitters display hypsochromically shifted emission falling into the blue to the cyan regions with higher photoluminescence quantum yields (PLQY). The optical properties were further elucidated by means of computational analysis employing (time-dependent) density functional theory, namely, (TD)-DFT.…”

Section: ■ Introductionmentioning

confidence: 94%

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True- to Sky-Blue Emitters Bearing the Thiazolo[5,4-d]thiazole Electron Acceptor for Single and Tandem Organic Light-Emitting Diodes

Jouaiti

Huang

Giuso

et al. 2023

ACS Appl. Electron. Mater.

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A series of emitters displaying efficient photoluminescence (PL) and electroluminescence (EL) into the trueto sky-blue regions is herein described and employed as electroluminescent materials for the fabrication of efficient blue organic light-emitting diodes (OLEDs). The compounds possess linear, yet a twisted, donor−π−acceptor−π−donor (D−π−A−π− D) architecture, where D and A are a (substituted) carbazole (Cz) and thiazolo [5,4-d]thiazole (TzTz) moiety as the electron donor and accepting unit, respectively. D = 9H-carbazol-9-yl and 3,6-ditert-butyl-9H-carbazol-9-yl for compounds TzTz-PCz2 and TzTz-PtbCz2, respectively. In dilute CH 2 Cl 2 solutions, both compounds display intense (PL quantum yield = 60−74%) and short-lived (τ = ca. 0.8−2.0 ns) luminescence arising from an intramolecular charge-transfer ( 1 ICT) excited state and falling into the sky-blue to the greenish-blue region (λ em = 448−502 nm). Compared to the previously reported TzTz-TPA parental emitters that features two triphenylamine (TPA) donor groups, the highly twisted nature and less extended π-conjugation of the donor−acceptor TzTz-PCz2 and TzTz-PtbCz2 counterparts herein presented enable to widen the HOMO−LUMO energy gaps and warrant blue shifting of the emission. Finally, OLED devices fabricated by employing the herein proposed emitters are presented as well with both single-and tandem-device architectures. The so-prepared OLEDs display true-blue to sky-blue EL peaking at λ EL,max = 460 nm (TzTz-PCz2) and 467−470 nm (TzTz-PtbCz2) and achieve maximum external quantum efficiency and luminance of 10.2% and 44,851 cd m −2 (for TzTz-PtbCz2) in the case of a tandem device, respectively, with a mitigated roll-off efficiency. These results demonstrate that the tandem device employing these TzTz donor−acceptor blue emitters raises the feasibility of fluorescent compounds to compete with other potential emitters in practical applications.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 94%

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True- to Sky-Blue Emitters Bearing the Thiazolo[5,4-d]thiazole Electron Acceptor for Single and Tandem Organic Light-Emitting Diodes

Jouaiti

Huang

Giuso

et al. 2023

ACS Appl. Electron. Mater.

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“…In vivo experiments TSY extract exhibits good analgesic and sedative effects. [90] Polysaccharide rich extract (PRE) isolated from Tc, on the survival of intracellular MTB strains and activation of macrophages, was investigated. PRE treatment up regulated the expression of pro-inflammatory cytokines such as IL-β, TNF-α, IL-6, IL-12, and IFN-γ in RAW 264.7 cell line.…”

Section: Anti-gout Propertiesmentioning

confidence: 99%

Untitled

2023

IJGP

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Present review article describes phytochemicals, disease prevention, and biological effects of Tinospora cordifolia commonly known as Giloy or Giloe" or "Guduchi." This plant is indigenous to tropical regions of the Indian subcontinent and widely used in Ayurvedic medicines since time immemorial. This article emphasized important biological activities such as anti-toxic, antipyretic, anti-inflammatory, antidiabetic, antioxidant, Antimicrobial, anti-stress, hypolipidaemic, hepatic disorder, anti-cancer, anti-HIV, anti-complementary, antitoxic effects, wound healing, anti-complementary, and immune stimulatory and immunomodulating activities. Plant is widely used by local people for treatment of fever, cough, cold, allergic rhinitis, and diabetes. Regular used of Giloy leaf juice cut down sugar, it induces generation of insulin that regulates blood sugar levels. Giloy juice is highly beneficial in liver disease, urinary tract infections, ulcer, kidney problems, and heart-related issues. Giloy juice acts as an appetizer, digestive, and help to remove cough and as immunity booster. It is also used to detoxify skin, improves digestion, and reduces digestion-related problems like diarrhea, colitis, vomiting, and hyperacidity. Giloy is unique plant and depository of hundreds of diverse bioactive constituents. These are used to prepare diverse rasayana' for therapeutic purposes mainly for saving the life of people. Due to life saving natural attributes, this plant is known as Amrita "that provides immortality" to people and immunity booster. Giloy plant hot concoction and extracts were proved boon for people as it has saved millions of lives during corona virus epidemics. Plant is used for the various human diseases and ailments related to liver, gastric, respiratory, urinary tract infections, ulcer, kidney and heart and skin.

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“…23,24 Simultaneously, the abundant surface functional groups of LBG make it possible to combine with other materials for synthesizing new materials with excellent performance. 25,26 Matar et al synthesized a LBG/PVA hydrogel using the gel casting method, which exhibited good pH and temperatureresponsive behavior and could be used as a candidate biomaterial for drug delivery applications. 27 Kaity et al designed an acrylamide-grafted copolymer of LBG through microwave irradiation and were able to achieve controlled release of buflomedil hydrochloride.…”

Section: Introductionmentioning

confidence: 99%

A photocrosslinked methacrylated carboxymethyl chitosan/oxidized locust bean gum double network hydrogel for cartilage repair

Cheng,

Peng,

Luo

et al. 2023

J. Mater. Chem. B

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The combined analgesic, sedative, and anti-gastric cancer mechanisms of Tinospora sagittata var. yunnanensis (S. Y. Hu) H. S. Lo based on integrated ethnopharmacological data

Cited by 6 publications

References 35 publications

True- to Sky-Blue Emitters Bearing the Thiazolo[5,4-d]thiazole Electron Acceptor for Single and Tandem Organic Light-Emitting Diodes

True- to Sky-Blue Emitters Bearing the Thiazolo[5,4-d]thiazole Electron Acceptor for Single and Tandem Organic Light-Emitting Diodes

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A photocrosslinked methacrylated carboxymethyl chitosan/oxidized locust bean gum double network hydrogel for cartilage repair

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