2012
DOI: 10.1111/j.1601-183x.2012.00866.x
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The combined effects of the 5‐ HTTLPR and HTR1A rs6295 polymorphisms modulate decision making in schizophrenia patients

Abstract: Decision making ability has been reported to be impaired in schizophrenia patients, but no research has examined the genetic bases of this impairment. This study investigated how decision making was affected by the genetic variants in the serotonin transporter gene (triallelic 5-HTTLPR) and serotonin receptor 1A gene (rs6295) and their interaction in 465 schizophrenia patients and 448 healthy controls. The Iowa Gambling Task (IGT) was used to evaluate decision making under ambiguity (the first 40 trials) and d… Show more

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Cited by 17 publications
(9 citation statements)
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“…Increased activity of the DMN could correlate with the increased rumination and selffocus observed in major depression. 94 Cognitive function was also affected in people with the G allele, with poorer performance on the Iowa gambling test (in combination with 5-HTTLPR ss) 95 and impaired working memory in premenstrual dysphoric disorder. 96 Conversely, depressed patients with the CC genotype showed better performance in a battery of 9 cognitive tests.…”
Section: Htr1a Rs6295 and Phenotypic/brain Network Alterationsmentioning
confidence: 99%
“…Increased activity of the DMN could correlate with the increased rumination and selffocus observed in major depression. 94 Cognitive function was also affected in people with the G allele, with poorer performance on the Iowa gambling test (in combination with 5-HTTLPR ss) 95 and impaired working memory in premenstrual dysphoric disorder. 96 Conversely, depressed patients with the CC genotype showed better performance in a battery of 9 cognitive tests.…”
Section: Htr1a Rs6295 and Phenotypic/brain Network Alterationsmentioning
confidence: 99%
“…HTR1A encodes the receptor 1A of serotonin and modulates hippocampal γ oscillations, seemingly impacting on behavioral and cognitive functions, such as learning and memory linked to serotonin function (Johnston et al, 2014). Several studies involving common polymorphisms of this gene highlight HTR1A as a promising candidate for schizophrenia risk, treatment response to the disease, and cognitive dysfunction in this condition (Gu et al, 2013; Lin et al, 2015; Takekita et al, 2015). Similarly, receptors of NMDA, particularly those containing the subunit NR2A, encoded by GRIN2A , are known to be reduced in fast-firing interneurons in schizophrenics, which plays a critical role in γ oscillation formation; a blockade of NR2A-containing receptors gives rise to strong increases in γ power and a reduction in low-frequency γ modulation (Kocsis, 2012).…”
Section: Schizophrenia-related Genes and Some Evolutionary Concernsmentioning
confidence: 99%
“…Previous association mapping studies based on this gene have produced varying results on the association significance of this gene in different populations [Ikeda et al, ; Kishi et al, ]. Studies in East Asian or Chinese‐Han populations have resulted in either no signals [Kim and Yoon, ; Zhou et al, ] or marginally significant signals [Gu et al, ].…”
Section: Introductionmentioning
confidence: 99%