The effectiveness of Malathion and Lufenuron alone and their mixtures against Trogoderma granarium larvae was investigated. The obtained results showed that Malathion was more toxic to the tested insect larvae than Lufenuron and the mixtures of Malathion with Lufenuron concentrations were more effective than each compound alone. Malathion at the highest concentration gave 65.5% larval mortality after 14 days, while the corresponding value of Lufenuron was only 33.3%. In addition, the presence of larvae in grain treated with Lufenuron extends the larval stage for a long time that increases the toxic effect of Malathion and should reduce adult emergence. An additive effect on the larval mortality and reduction rates in T. granarium adult emergence was achieved when Malathion at 4ppm mixed with each concentration of Lufenuron.