The Combined Extract of Black Sticky Rice and Dill Improves Poststroke Cognitive Impairment in Metabolic Syndrome Condition

Ohnon, Warin; Thukham-mee, Wipawee; Muchimapura, Supaporn; Wannanon, Panakaporn; Tong-Un, Terdthai

doi:10.1155/2019/9089035

Cited by 15 publications

(20 citation statements)

References 54 publications

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“…Rice extract and the purified compounds from rice have been reported to act as biological agents for improved human health, especially coloured rice 7,8 . The extract of black sticky rice ( Oryza sativa L) combined with dill has improved poststroke cognitive impairment in metabolic syndrome condition 9 . Lee et al 10 showed that the purified compound from black rice ( O sativa L) had the inhibitory activity on breast cancer cell proliferation and hyperglycaemia.…”

Section: Introductionmentioning

confidence: 99%

α‐glucosidase, α‐amylase inhibitory potential and antioxidant activity of fragrant black rice (Thai coloured rice)

Sansenya

Nanok

2020

Flavour & Fragrance J

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Diabetes mellitus is the most serious metabolic disorder in the world. 1 A recent report from the World Health Organization (WHO) showed that more than 422 million people worldwide have diabetes, especially in low-and middle-income countries. Diabetes mellitus can be divided into two types: insulin-dependent (type 1 diabetes mellitus) and non-insulin-dependent (type 2 diabetes mellitus). The common patients with diabetes are type 2 patients. Type 2 diabetes mellitus is caused by high blood glucose level which is hydrolysed from starch. 2 α-Glucosidase and α-amylase are the group of starch hydrolytic enzymes. The polysaccharides hydrolyse to short oligosaccharides or disaccharides by α-amylase, and finally, the free glucose is released from disaccharides by α-glucosidase. 3 The inhibiting both α-glucosidase and α-amylase has reported by varied plant bioactive compounds. Nazir et al 4 report that the chloroform extract of Elaeagnus umbellata (Thunb.) has shown high inhibitory potential on both α-glucosidase and α-amylase. Capsaicin and dihydrocapsaicin Abstract Coloured rice is the source of bioactive compounds related to medicinal treatment.This study aimed to investigate α-glucosidase and α-amylase inhibitory activity and antioxidant properties of purified coloured rice extract (Thai fragrant black rice). The results reveal that seven purified fractions; rice fractions 1-7 (RF1-RF7) contained several phytochemical compounds especially flavonoids, which were presented in all purified fractions. The percentage inhibition on α-glucosidase and α-amylase of fractions RF1, RF2, RF4, RF5 and RF6 had higher potential than acarbose. RF4, RF5 and RF6 contained the highest inhibition potential, which further determined the IC 50 values, kinetic analysis and antioxidant properties. The IC 50 values of all three fractions indicated that the inhibition potential of purified fraction had higher potential than acarbose, and the highest inhibition potential for both enzymes was obtained from fraction RF5. The kinetic analysis of the three fractions indicated that they are against both enzymes' function in mixed-type inhibition. Moreover, all three fractions also showed good antioxidant activity, and the highest potential was obtained from fraction RF6. This study presents the inhibition efficiency of fragrant black rice extract on α-glucosidase and α-amylase enzymes. The inhibitory activity of rice extract on both enzymes had higher potent than commercial standard drug acarbose.Moreover, the rice extract also shown the high-efficiency antioxidant activity on DPPH and ABTS assay. We suggest the application of these results in the development of anti-diabetes drug for pharmaceutical industry. K E Y W O R D Santioxidant potential, carbohydrate hydrolysis enzyme, Thai fragrant rice, type 2 diabetes mellitus

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Section: Introductionmentioning

confidence: 99%

α‐glucosidase, α‐amylase inhibitory potential and antioxidant activity of fragrant black rice (Thai coloured rice)

Sansenya

Nanok

2020

Flavour & Fragrance J

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“…Recently, it has been demonstrated that the substance possessing antioxidant and anti-inflammation such as the combined extract of black stick rice and dill significantly improves brain damage and deficits in an animal model of ischemic stroke in MetS condition [10,11]. Our previous study also clearly demonstrates that the phytosome containing the combined extract of ginger rhizome and mulberry fruit (PMG) can also decrease oxidative stress and inflammation [12].…”

Section: Introductionmentioning

confidence: 81%

Phytosome Loading the Combined Extract of Mulberry Fruit and Ginger Protects against Cerebral Ischemia in Metabolic Syndrome Rats

Palachai

Muchimapura

Thukham-mee

2020

Oxidative Medicine and Cellular Longevity

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The prevalence of ischemic stroke in metabolic syndrome (MetS) is continually increasing and produces a great impact on both qualities of life and annual healthcare budget. Due to the efficiency limitation of the current therapeutic strategy, the poor availability of polyphenol substances induced by the first pass effect and the beneficial effects of mulberry fruit and ginger on brain and MetS-related diseases together with the synergistic concept, the neuroprotective effect against ischemic stroke in MetS condition of phytosome containing the combined extract of mulberry fruit and ginger (PMG) has been considered. To explore the neuroprotective effect and possible underlying mechanism of PMG on brain damage in cerebral ischemic rat with MetS, male Wistar rats were induced MetS by high-carbohydrate high-fat diet (HCHF) for 16 weeks and subjected to the cerebral ischemia/reperfusion injury (CIRI) at the right middle cerebral artery (Rt. MCAO). PMG at doses of 50, 100, and 200 mg/kg were orally fed with for 21 days, and they were assessed brain damage, neurological deficit score, and the changes of oxidative stress markers, inflammatory markers, PPARγ expression, and epigenetic modification via DNMT-1 were performed. All doses of PMG significantly improved brain infarction, brain edema, and neurological deficit score. In addition, the reduction in DNMT-1, MDA level, NF-κB, TNFα, and C-reactive protein together with the increase in SOD, CAT, and GPH-Px activities, and PPARγ expression in the lesion brain were also observed. The current data clearly revealed the neuroprotective effect against cerebral ischemia with MetS condition. The possible underlying mechanism might occur partly via the suppression of DNMT-1 giving rise to the improvement of signal transduction via PPARγ resulting in the decreasing of inflammation and oxidative stress. In conclusion, PMG is the potential neuroprotectant candidate against ischemic stroke in the MetS condition. However, the clinical trial is still essential.

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“…The underlying mechanism of memory impairment in MetS appears to be associated with the reduction of many factors including the function of the cholinergic system and signal transduction via the ERK pathway together with the reduction of neuron density in the hippocampus [6]. Recently, it has been demonstrated that stroke in MetS can also induce memory impairment [7]. The underlying pathophysiology of the aforementioned condition is also associated with a reduction of the cholinergic system and neuron density in the hippocampus but with an increase in oxidative stress and inflammation [7].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, it has been demonstrated that stroke in MetS can also induce memory impairment [7]. The underlying pathophysiology of the aforementioned condition is also associated with a reduction of the cholinergic system and neuron density in the hippocampus but with an increase in oxidative stress and inflammation [7]. Since memory impairments in both MetS and MetS with stroke are associated with inflammation and the reduction of neuron density, the cognitive enhancing effect of substances possessing anti-inflammatory and neuroprotective effects have gained attention.…”

Section: Introductionmentioning

confidence: 99%

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Memory-Enhancing Effect of a Phytosome Containing the Combined Extract of Mulberry Fruit and Ginger in an Animal Model of Ischemic Stroke with Metabolic Syndrome

Palachai

Thukham-mee

Muchimapura

2020

Oxidative Medicine and Cellular Longevity

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The prevalence of dementia following cerebral ischemia in metabolic syndrome (MetS) condition is increasing, and most of the cases are often severe. Unfortunately, no effective strategy for treating this condition is available. Based on the positive modulation effect of a polyphenol-rich substance on dementia and the improvement in bioavailability and stability of polyphenols induced by the phytosome technique together with the use of the synergistic concept, we hypothesized that a phytosome containing the combined extract of mulberry fruit and ginger (PMG) should mitigate dementia and memory impairment following ischemic stroke in MetS. MetS was induced in male Wistar rats weighing 180-200 g by exposure to a 16-week feeding period of high-carbohydrate high-fat (HCHF) diet. MetS rats were orally given PMG at doses of 50, 100, and 200 mg·kg-1 BW 21 days before and 21 days after the occlusion of the right middle cerebral artery (Rt. MCAO). Then, their spatial memory was determined and the possible underlying mechanisms explored via the alterations of acetylcholinesterase (AChE), neuron density, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), interleukin-6 (IL-6), and signal transduction via extracellular signal-regulated kinase (ERK) pathway in both the cerebral cortex and the hippocampus. It was found that PMG significantly enhanced memory. It also decreased AChE, IL-6, and MDA but increased SOD, CAT, GSH-Px, neuron density, and phosphorylation of ERK. These data suggested the cognitive enhancing effect of PMG. The possible underlying mechanisms might occur partly via the improvement of cholinergic function via the ERK pathway together with the decrease in neurodegeneration induced by the reduction of oxidative stress and inflammation. However, a subchronic toxicity study is also required to assure the safety of PMG consumption before moving forward to a clinical trial study.

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The Combined Extract of Black Sticky Rice and Dill Improves Poststroke Cognitive Impairment in Metabolic Syndrome Condition

Cited by 15 publications

References 54 publications

α‐glucosidase, α‐amylase inhibitory potential and antioxidant activity of fragrant black rice (Thai coloured rice)

α‐glucosidase, α‐amylase inhibitory potential and antioxidant activity of fragrant black rice (Thai coloured rice)

Phytosome Loading the Combined Extract of Mulberry Fruit and Ginger Protects against Cerebral Ischemia in Metabolic Syndrome Rats

Memory-Enhancing Effect of a Phytosome Containing the Combined Extract of Mulberry Fruit and Ginger in an Animal Model of Ischemic Stroke with Metabolic Syndrome

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