The Combined Intervention of Therapy and Bromocriptine Mesylate to Improve Functional Performance After Brain Injury

Pulaski, Karen Halliday; Emmett, Lisa

doi:10.5014/ajot.48.3.263

Cited by 9 publications

(3 citation statements)

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“…It has been used to attenuate menstrual and fertility problems and to treat symptoms of Parkinson's disease. Previous clinical work has shown that bromocriptine combination treatment contributes to improved functional outcome after TBI [35,41]. In another study chronic bromocriptine treatment was shown to improve cognitive function and motivation after TBI [42].…”

Section: Neurotransmitter-based Posttraumatic Interventionsmentioning

confidence: 92%

A review of pharmacological treatments used in experimental models of traumatic brain injury

Kokiko

Hamm

2007

Brain Injury

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Understanding the relationship between neural disturbances and functional deficits following brain injury is challenging. Cognitive impairment may be the result of a single event or multiple events that occur after the initial insult. Increasing neuronal activity during the chronic phase of injury seems to be an effective treatment strategy for facilitating cognitive recovery. Pharmacological agents do not necessarily display the same effects in an injured brain as in a non-injured brain. Thus, further research is needed to establish the effectiveness of rehabilitative drug treatments.

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Section: Neurotransmitter-based Posttraumatic Interventionsmentioning

confidence: 92%

A review of pharmacological treatments used in experimental models of traumatic brain injury

Kokiko

Hamm

2007

Brain Injury

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“…Furthermore, a chronic and delayed administration paradigm of BRO enhances both working and reference memory [58]. Clinically, anecdotal reports have described functional improvement after TBI with BRO treatment, with or without occupational and physical therapy [59‐63]. In a small, double‐blind, placebo‐controlled crossover study, BRO treatment was reported to improve performance on clinical measures of executive function [64].…”

Section: Neurotransmitters and Plasticitymentioning

confidence: 99%

Biologic and Plastic Effects of Experimental Traumatic Brain Injury Treatment Paradigms and Their Relevance to Clinical Rehabilitation

Garcia

Shah

Dixon

et al. 2011

PM&R

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“…to t.i.d. with food and may be increased by 1.25 mg weekly to a maximal daily dose of 90 mg in three divided doses [11][12][13][14]. Arousal, attention and functional activities should be monitored closely.…”

Section: Bromocriptinementioning

confidence: 99%

Road to recovery: drugs used in stroke rehabilitation

Zorowitz¹

2004

Expert Review of Neurotherapeutics

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The practice of neurorehabilitation is unique in that it supplements treatments with medications which complement and expedite the rehabilitation process. In stroke rehabilitation, medications can be used not only to treat poststroke secondary complications but also to facilitate recovery. Since only thrombolytics have been demonstrated to be effective in minimizing brain damage and maximizing functional outcome, intensive rehabilitation remains the most significant and important means by which stroke survivors possibly may maximize stroke recovery. There is an opportunity to complement intensive rehabilitation with pharmacologic interventions that facilitate the recovery of damaged neurons as well as plastic responses in underutilized and unused brain tissue. However, few of these medications have been approved for these indications or have been subjected to large randomized clinical trials. Nonetheless, this review identifies areas in stroke rehabilitation that can be addressed with neuropharmacologic agents, lists specific medications currently used to treat these conditions and describes the evidence that supports the recommendations for these medications.

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The Combined Intervention of Therapy and Bromocriptine Mesylate to Improve Functional Performance After Brain Injury

Cited by 9 publications

References 0 publications

A review of pharmacological treatments used in experimental models of traumatic brain injury

A review of pharmacological treatments used in experimental models of traumatic brain injury

Biologic and Plastic Effects of Experimental Traumatic Brain Injury Treatment Paradigms and Their Relevance to Clinical Rehabilitation

Road to recovery: drugs used in stroke rehabilitation

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