The Common Variant rs4444235 near BMP4 Confers Genetic Susceptibility of Colorectal Cancer: An Updated Meta-Analysis Based on a Comprehensive Statistical Strategy

Liu, Li; Su, Qinji; Li, Lixia; Lin, Xiaohui; Gan, Yu; Chen, Sidong

doi:10.1371/journal.pone.0100133

Cited by 3 publications

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References 32 publications

(46 reference statements)

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“…A study by Liu et al (2014) used a comprehensive strategy of logistic regression and a mode-free approach to more precisely evaluate the role of BMP4 rs4444235 in susceptibility to colorectal cancer (CRC). A total of 19 studies with 28770 cases and 28234 controls were included.…”

Section: Association Between Bmp4 Rs4444235 Gene Polymorphism and Gra...mentioning

confidence: 99%

Association of BMP4 RS444235 Gene Polymorphism and the Stage and Grade of Colorectal Cancer at Prof. dr. I G.N.G Ngoerah General Hospital

Mutiara,

Nyoman Ayu Dewi,

Ayu Ika Wahyuniari

et al. 2023

IJRP

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Aging is one of the main risk factors for cancer, with one of the most common in the elderly population is colorectal cancer, which is the third most common cancer and the fourth most common cause of death in the world. One of the biomarkers studied which is related to the balance of colorectal cancer tumorigenesis is bone morphogenetic proteins (BMPs). The BMP4 gene polymorphism, namely BMP4 rs4444235, has been associated with an increased risk of colorectal cancer. This study used a crosssectional analytical method to analyze the relationship between the BMP4 rs44444235 gene polymorphism and colorectal cancer at Prof. dr. I G.N.G. Ngoerah General Hospital using 41 FFPE samples from colorectal cancer. The identification of BMP4 rs4444235 gene polymorphism was carried out using the Polymerase Chain Reaction (PCR) and sequencing. The data obtained was then processed using SPSS 25.0. Out of 30 colorectal cancer patients, 17 samples (56.7%) were male and 13 samples (43.3%) were female, with 24 samples (60%) had advanced stage colorectal cancer and 6 samples (20%) had early stage. A number of 28 samples (93.3%) were of low-grade colorectal cancer and 2 samples (6.7%) were of high grade. BMP4 gene polymorphism rs4444235 of CC genotype were found in 8 samples (26.7%), a CT genotype in 14 samples (46.7%), while a TT genotype in 8 samples (26.7%). The test showed the BMP4 rs4444235 gene polymorphism was not associated with the stage and grade of colorectal cancer (p>0.05), with p value of 0.547 and 0.294 for stage and grade of colorectal cancer respectively.Taken together, BMP4 rs4444235 gene polymorphism was identified, however there was no association found with the stage and grade of colorectal cancer at Prof. dr. I G.N.G. Ngoerah General Hospital.

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Section: Association Between Bmp4 Rs4444235 Gene Polymorphism and Gra...mentioning

confidence: 99%

Association of BMP4 RS444235 Gene Polymorphism and the Stage and Grade of Colorectal Cancer at Prof. dr. I G.N.G Ngoerah General Hospital

Mutiara,

Nyoman Ayu Dewi,

Ayu Ika Wahyuniari

et al. 2023

IJRP

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“…The SNPs analyzed for colorectal cancer were rs4444235, rs4939827, rs7014346, rs9929218, rs3802842, rs10411210, rs16892766, rs961253 and rs6983267. The specific variations for each SNP were as follows (Liu et al, 2014;Yao et al, 2015).…”

Section: Genotyping Analysismentioning

confidence: 99%

Association Between Cancer Screening Results Using Single Nucleotide Polymorphism and Cancer Incidence Rate in Korean Women

Lee,

Kim

2023

American Journal of Biochemistry and Biotechnology

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In this study, we investigated the usefulness of Single Nucleotide Polymorphism (SNP) testing in assessing cancer susceptibility in women by evaluating correlations between SNP testing results and cancer incidence rates. SNP testing was conducted on blood samples of women who underwent health examinations commissioned by medical institutions in the Republic of Korea in 2017 using real-time polymerase chain reaction with OpenArray testing. The SNP panel included susceptibility testing for lung, stomach, colorectal, breast, and thyroid cancers. By comparing the proportions of the normal, cautionary, and warning ranges for these five types of cancer obtained from OpenArray testing with the cancer incidence rates for women in 2017, as reported by the national cancer information center, the practical preventive potential of SNP-based testing was evaluated. Cancer susceptibility in women was the highest for breast cancer, followed by thyroid, colorectal, gastric, and lung cancers. These five types of cancer showed the same trend for cancer incidence in 2017. Based on cumulative percentages of the 5-year cancer prevalence (2013)(2014)(2015)(2016)(2017) in Korean women, thyroid cancer ranked first, followed by breast, colon, gastric, and lung cancers. Although the breast and thyroid cancer ordinals differed, their proportion was 49.4% higher than that of the other three cancer types for both the 2017 and 5-year incidence. The high rate of 95.3% in the caution and warning intervals for breast and thyroid cancers in the OpenArray test results suggests a correlation with the reported cancer incidence in 2017. These results indicate that SNP testing, although not aimed directly at diagnosing specific diseases in direct-to-consumer tests or health check-ups, can help individuals identify their genetic susceptibility to cancer, thus allowing them to implement preventive measures.

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“…The SNP rs4444235, which is located 9.4 kb upstream of the gene encoding bone morphogenetic protein 4 (BMP4), was previously associated with CRC and gastric cancer risk [22,23] . Although the CT genotype showed a protective effect against gastric cancer [23] , it was also associated with an increased CRC risk [24] . This SNP has been proposed to act as a cis-regulator of BMP4 and thus confer a risk for CRC [25,26] .…”

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Association of colorectal cancer susceptibility variants with esophageal cancer in a Chinese population

Geng

Xun

et al. 2015

WJG

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AIM:To investigate the association between colorectal cancer (CRC) genetic susceptibility variants and esophageal cancer in a Chinese Han population. METHODS:A case-control study was conducted including 360 esophageal cancer patients and 310 healthy controls. Thirty-one single-nucleotide polymorphisms (SNPs) associated with CRC risk from previous genome-wide association studies were analyzed. SNPs were genotyped using Sequenom Mass-ARRAY technology, and genotypic frequencies in controls were tested for departure from HardyWeinberg equilibrium using a Fisher's exact test. The allelic frequencies were compared between cases and controls using a χ 2 test. Associations between the SNPs and the risk of esophageal cancer were tested using various genetic models (codominant, dominant, recessive, overdominant, and additive). ORs and 95%CIs were calculated by unconditional logistic regression with adjustments for age and sex. RESULTS:The minor alleles of rs1321311 and rs4444235 were associated with a 1.53-fold (95%CI: ORIGINAL ARTICLE Case Control StudyAssociation of colorectal cancer susceptibility variants with esophageal cancer in a Chinese population of esophageal cancer, squamous cell carcinoma is the most common, and prognosis highly correlates with disease stage and advancement.Epidemiologic studies indicate that tobacco smoking, alcohol intake, nutritional deficiencies, and dietary carcinogen exposure contribute to the etiology of esophageal cancer [4,5] . However, only a small proportion of individuals exposed to these factors actually develop esophageal cancer, suggesting that genetic factors also play a vital role in susceptibility. It has been reported that susceptibility to esophageal cancer is not dependent on a single gene and is affected by population differences [6,7] . Colorectal cancer (CRC) is the most common malignant tumor of the digestive tract, and the second most common of all gastrointestinal tumors [8] . Recent studies have identified haplotype-tagging singlenucleotide polymorphisms (SNPs) that are associated with an increased colorectal cancer risk in the general population [9][10][11][12] . Previous genetic polymorphism studies in the Chinese population were focused solely on SNPs associated with esophageal cancer risk in genome-wide association studies (GWAS) [13][14][15] . The purpose of the present study was to identify digestive system tumor common susceptibility loci. To achieve this, 31 high-frequency SNPs associated with CRC risk in the Chinese population were evaluated with respect to esophageal cancer risk. MATERIALS AND METHODS Study participantsAll participants were Chinese Han that were seen between January 2011 and February 2014 at the First Affiliated Hospital of the Medical College of Xi'an Jiaotong University. None of the study participants received neoadjuvant therapy or had previous histories of other cancers, chemotherapy, or radiotherapy. Participants were chosen without restrictions of age, sex, or disease stage. None of the healthy control subjects had a...

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The Common Variant rs4444235 near BMP4 Confers Genetic Susceptibility of Colorectal Cancer: An Updated Meta-Analysis Based on a Comprehensive Statistical Strategy

Cited by 3 publications

References 32 publications

Association of BMP4 RS444235 Gene Polymorphism and the Stage and Grade of Colorectal Cancer at Prof. dr. I G.N.G Ngoerah General Hospital

Association of BMP4 RS444235 Gene Polymorphism and the Stage and Grade of Colorectal Cancer at Prof. dr. I G.N.G Ngoerah General Hospital

Association Between Cancer Screening Results Using Single Nucleotide Polymorphism and Cancer Incidence Rate in Korean Women

Association of colorectal cancer susceptibility variants with esophageal cancer in a Chinese population

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