The comparative anticaries efficacy of Crest toothpaste relative to some marketed Chinese toothpastes – results of in vitro pH cycling testing

Abstract

Summary Several laboratory studies have been conducted to confirm and compare the anticaries potential of the major fluoride toothpastes currently marketed in China. This paper reports on one series of tests that was conducted under the guidance of the China National Committee for Oral Health (NCOH). In this series of tests, one of the marketed toothpastes, which is formulated with sodium fluoride (NaF) in a silica abrasive that is highly compatible with the fluoride active ingredient, provided significantly greater efficacy than all of the other toothpastes tested. This product is Crest toothpaste. On the basis of a separate series of studies conducted independently by the NCOH, Crest toothpaste received the official endorsement of the China NCOH as a proven anticaries toothpaste. The studies reported here provide additional, quantitative verification of the efficacy of this formulation. Included in this assessment of anticaries efficacy were measurements of fluoride uptake into demineralised human enamel, changes in the surface microhardness of the enamel as a function of each product tested, post resistance of remineralised enamel that was subjected to a secondary acid challenge, and quantitative microradiographic analyses of remineralised specimens. Each parameter demonstrates Crest toothpaste provides a higher level of anticaries efficacy than other fluoride toothpastes marketed in China. The results of these tests are consistent with previous tests conducted by the NCOH. Comparatif d'efficacité contre les caries du dentifrice Crest et de quelques dentifrices commercialisés en Chine ‐ résultats d'un test de mise en cycle du pH in vitro Résumé Plusieurs études ont été menées en laboratoire afin de confirmer et de comparer le potentiel cariostatique des principaux dentifrices fluorés, actuellement vendus en Chine. Cet article relate l'une des séries de tests effectués sous le contrôle du Comité National Chinois pour la Santé Bucco‐Dentaire (NCOH). Dans ce groupe de tests, l'un des dentifrices commercialisés, à base de fluor de sodium (NaF) intégré dans un abrasif au silice hautement compatible avec le fluor actif, s'est révélé nettement plus efficace que tous les autres dentifrices testés. Il s'agit du dentifrice Crest. A partir d'une série particulière de tests assurés indèpendamment par le NCOH, le dentifrice Crest a étè officiellement reconnu par le NCOH comme étant un dentifrice capable de combattre les caries. Les études dont il est question dans cet article apportent des preuves quantitatives supplèmentaires sur l'efficacité de cette formule. Parallèlement à cette évaluation de l'action cariostatique, on a mesuré la dose de fluor absorbée par l'émail humain déminéralisé, les changements dans la microdureté de surface de l'émail pour chaque produit testé, la post résistance de l'émail reminéralisé en le soumettant à une attaque acide secondaire. On a également procédé à des analyses quantitatives par microradiographie des spécimens reminéralisés. Chaque paramètre prouve que le dentifrice Crest est beaucou...

Potential agents to control enamel caries-like lesions

“…1,25,26,[28][29][30][31][32][33] SMH evaluations are a simple, fast and easy-to measure nondestructive method, 34 reflecting mineral changes that have occurred due to treatments. 1,26,28,31 The method also allows repeated measurements of the same specimen over a given period of time, reducing the experimental variation, 19 reinfor- cing that SMH evaluations seem to be a feasible choice to estimate mineral changes.…”

Anticaries Potential of Commercial Dentifrices as Determined by Fluoridation and Remineralization Efficiency

“…22,37 In addition, toothpastes with roughly the same theoretical fluoride content do not always produce the same level of fluoride uptake. 23,24 The fluoride uptake values of 34.9 to 40.4 μg/cm 2 for Groups 2 and 3, respectively, did not differ significantly. Groups 1, 4, and 5 all yielded significantly lower fluoride uptake than preparations 2 and 3; (p < 0.05 by the Tukey-Kramer HSD test), in spite of the fact all of the products tested had higher total fluoride concentrations than Group 2 (1100 ppm F as NaF).…”

“…The demineralization solution consisted of 0.1 M lactic acid and 0.2% polyacrylic acid (Carbopol C907, B.F. Goodrich Company, Cleveland, OH, USA), 50% saturated with hydroxyapatite, and prepared according to the Carbopol method of White.34 This method produces lesions with a depth of approximately 50-80 μm, and use of this lesion has been reported in other publications using a similar pH cycling model. 22,23,35…”

“…The in vitro model design o used in this study has been previously confirmed to demonstrate dose response sensitivity as well as identify potential differences in product performance and efficiency. 22,23 In vitro models o have demonstrated the amount of bioavailable fluoride in a toothpaste formulation is a more efficient predictor of potential anticaries efficacy than simple measures of total fluoride incorporated into a commercially available product. [24][25][26] There have been several experiments concerning how much fluoride is taken up in caries-free or experimentally demineralized enamel samples after use of various toothpastes with different fluoride compounds.…”

“…24,[27][28][29][30][31][32] Other studies have utilized surface microhardness, or combinations of fluoride uptake and microhardness, as a means to demonstrate not only how much fluoride incorporates into a tooth during treatment but also to reflect mineral changes (remineralization) that have occurred within the tooth as a function of treatments. 15,16,23,33 Almost all of these studies compared products containing single sources of fluoride. Globally, both single fluoride sourced products (NaF, SnF 2 , AmF, or SMFP) as well as dual fluoride active products (NaF+SMFP, AmF+SnF 2 ) are commercially available.…”