Aim:The aim of this in vitro study was to investigate fluoride uptake in human enamel after use of o commercially available toothpastes containing different fluoride compounds, or combinations of fluoride actives formulated into a single product, as a means of determining the efficiency of each formula for delivering caries preventing fluoride to demineralized (caries active) enamel.Group 6: A placebo (formulated the same as the USP Reference Standard toothpaste with the exception that it contained < 1 ppm F). Cores 3 mm in diameter were removed from erupted human enamel specimens (extracted by local oral surgeons for orthodontic reasons) and stored in 1% Thymol solution prior to use. They were ground and polished to remove the natural fluoride rich enamel layer, then exposed to a demineralization solution, and assessed for surface microhardness to enable randomization for use in the study. Each group of five specimens underwent a daily pH cycling procedure that involved exposure to pooled human saliva (refreshed three times daily). The groups were then exposed to dentifrice slurries four times daily for one minute per exposure and to a demineralization solution for three hours. The cycling procedure was repeated for five days. Specimens were again analyzed for surface microhardness and fluoride uptake upon completion of five days of treatment. Abstract © Seer Publishing

Summary Several laboratory studies have been conducted to confirm and compare the anticaries potential of the major fluoride toothpastes currently marketed in China. This paper reports on one series of tests that was conducted under the guidance of the China National Committee for Oral Health (NCOH). In this series of tests, one of the marketed toothpastes, which is formulated with sodium fluoride (NaF) in a silica abrasive that is highly compatible with the fluoride active ingredient, provided significantly greater efficacy than all of the other toothpastes tested. This product is Crest toothpaste. On the basis of a separate series of studies conducted independently by the NCOH, Crest toothpaste received the official endorsement of the China NCOH as a proven anticaries toothpaste. The studies reported here provide additional, quantitative verification of the efficacy of this formulation. Included in this assessment of anticaries efficacy were measurements of fluoride uptake into demineralised human enamel, changes in the surface microhardness of the enamel as a function of each product tested, post resistance of remineralised enamel that was subjected to a secondary acid challenge, and quantitative microradiographic analyses of remineralised specimens. Each parameter demonstrates Crest toothpaste provides a higher level of anticaries efficacy than other fluoride toothpastes marketed in China. The results of these tests are consistent with previous tests conducted by the NCOH. Comparatif d'efficacité contre les caries du dentifrice Crest et de quelques dentifrices commercialisés en Chine ‐ résultats d'un test de mise en cycle du pH in vitro Résumé Plusieurs études ont été menées en laboratoire afin de confirmer et de comparer le potentiel cariostatique des principaux dentifrices fluorés, actuellement vendus en Chine. Cet article relate l'une des séries de tests effectués sous le contrôle du Comité National Chinois pour la Santé Bucco‐Dentaire (NCOH). Dans ce groupe de tests, l'un des dentifrices commercialisés, à base de fluor de sodium (NaF) intégré dans un abrasif au silice hautement compatible avec le fluor actif, s'est révélé nettement plus efficace que tous les autres dentifrices testés. Il s'agit du dentifrice Crest. A partir d'une série particulière de tests assurés indèpendamment par le NCOH, le dentifrice Crest a étè officiellement reconnu par le NCOH comme étant un dentifrice capable de combattre les caries. Les études dont il est question dans cet article apportent des preuves quantitatives supplèmentaires sur l'efficacité de cette formule. Parallèlement à cette évaluation de l'action cariostatique, on a mesuré la dose de fluor absorbée par l'émail humain déminéralisé, les changements dans la microdureté de surface de l'émail pour chaque produit testé, la post résistance de l'émail reminéralisé en le soumettant à une attaque acide secondaire. On a également procédé à des analyses quantitatives par microradiographie des spécimens reminéralisés. Chaque paramètre prouve que le dentifrice Crest est beaucou...