The comparative effects of dietary monensin and propylene glycol on insulin resistance of transition dairy cows

Chalmeh, Aliasghar; Pourjafar, Mehrdad; Badiei, Khalil; Jalali, Mehrdad; Sebdani, Mohammad Mazrouei

doi:10.1007/s11250-019-02160-1

Cited by 8 publications

(4 citation statements)

References 31 publications

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“…At the end of the test period which coincides with a higher energy demand of the lambs, a decrease in BHBA concentration together with a decrease in tryglicerides concentration was observed in lambs supplemented with the highest doses of PPG. Nielsen and Ingvartsen (2004), Kristensen and Raund (2007), Bjerre-Harpøth et al (2015) and Chalmeh et al (2020) stated that PPG caused an increase in the glucogenic status and a reduction of adipose tissue mobilization, which leads to decrease NEFA in the liver and reduction in the formation of ketone bodies. In this way, Kalyesubula et al (2019) concluded that treatment with PPG effectively reduced hyperketonemia and lipolysis.…”

Section: Discussionmentioning

confidence: 99%

Effect of Propylene Glycol on Blood Metabolites, Ruminal and Productive Parameters of Growing-Finishing Lambs

Vargas

Tristán

Segura

et al. 2022

Trop Subtrop Agroecosyst

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Background. Propylene glycol has been used successfully since the 1950’s for him acute and prophylactic treatment of ketosis in dairy cows however; its use has been poorly evaluated in beef cattle and meat sheep. Objective. Evaluate the effects of different doses of propylene glycol on the productive parameters, blood metabolites and ruminal parameters in fattening lambs. Methodology. Twenty lambs 14.70 ±0.57 kg of weigh, 2 months old, males and Katahdin-Black Belly breed, were randomly assigned to one of four treatments, a control mixed ration and an experimental diet with three different levels of propylene glycol: 1.0, 1.5 and 2.0 g/20 kg live weight/day. The effects of propylene glycol on blood metabolites, ruminal and productive parameters were assessed. Results. Propylene glycol supplementation did not affect (P>0.05) glucose, total lipids, triglycerides and cholesterol concentration as well as increased (P<0.05) the concentration of beta hydroxybutyrate. In addition, its inclusion resulted in an increase in pH and protozoa population and in a decrease of reductive activity (P<0.05). No effect was observed (P>0.05) on feed intake, weight gain and feed conversion ratio of lambs but carcass yield was improved without increasing the feeding cost of production. Implications. Propylene glycol is a viable option as an energy source in fattening lambs. Conclusion. Inclusion of PPG increased the pH and the population of ruminal protozoa, reduced the formation of ketone bodies and improved the carcass yield of lambs without increasing the meat production cost.

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Section: Discussionmentioning

confidence: 99%

Effect of Propylene Glycol on Blood Metabolites, Ruminal and Productive Parameters of Growing-Finishing Lambs

Vargas

Tristán

Segura

et al. 2022

Trop Subtrop Agroecosyst

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“…The greater extent of insulin resistance in peripartal dairy cows can contribute to excessive adipose tissue lipolysis and thus greater metabolic disease risk [58]. Chalmeh et al [59] confirmed that the supplementary feeding with PG reduced the insulin resistance in dairy cows during the transition period by the intravenous glucose tolerance test. The decrease in insulin resistance will inhibit lipolysis and decrease the metabolic disease risk in periparturient dairy cattle.…”

Section: The Anti-ketogenic Properties Of Pg and The Mechanism Of Inhmentioning

confidence: 99%

“…The reduction in plasma NEFA and increase in plasma glucose are related to the anti-ketogenic property of PG. The use of PG is likely to produce more propionate as the main precursor of glucose; therefore, it can reduce the NEB and insulin resistance [59]. Therefore, the PG supplement to dairy cows can decrease nutritional metabolic diseases in early lactation.…”

Section: The Effect Of Pg On Metabolic Indexmentioning

confidence: 99%

Effects of Propylene Glycol on Negative Energy Balance of Postpartum Dairy Cows

Zhang

Nan

Wang

et al. 2020

Animals

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With the improvement in the intense genetic selection of dairy cows, advanced management strategies, and improved feed quality and disease control, milk production level has been greatly improved. However, the negative energy balance (NEB) is increasingly serious at the postpartum stage because the intake of nutrients cannot meet the demand of quickly improved milk production. The NEB leads to a large amount of body fat mobilization and consequently the elevated production of ketones, which causes metabolic diseases such as ketosis and fatty liver. The high milk production of dairy cows in early lactation aggravates NEB. The metabolic diseases lead to metabolic disorders, a decrease in reproductive performance, and lactation performance decline, seriously affecting the health and production of cows. Propylene glycol (PG) can alleviate NEB through gluconeogenesis and inhibit the synthesis of ketone bodies. In addition, PG improves milk yield, reproduction, and immune performance by improving plasma glucose and liver function in ketosis cows, and reduces milk fat percentage. However, a large dose of PG (above 500 g/d) has toxic and side effects in cows. The feeding method used was an oral drench. The combination of PG with some other additives can improve the effects in preventing ketosis. Overall, the present review summarizes the recent research progress in the impacts of NEB in dairy cows and the properties of PG in alleviating NEB and reducing the risk of ketosis.

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“…Показано, что у животных с овариальной недостаточностью наблюдается дефицит глюкозы в первые два месяца лактации [7,11,12]. В месте с тем, установлено, что при некоторых патологических состояниях уровень данного метаболита может находится в норме или наоборот быть повешенным [2,3]. Так у голштинского скота была показана предрасположенность к инсулинорезистентностности и нарушению толерантности к глюкозе, которая характеризуется невозможностью тканей организма эффективно поглощать и использовать глюкозу, циркулирующую с кровотоком [4,6].…”

Section: введение / Introductionunclassified

The effect of the concentration of β-hydroxybutyrate and glucose in the blood on the reproductive function and milk productivity of cows

Nikolaev

2023

jour

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The intensity of metabolic processes in highly productive cows is associated with metabolic disorders and the development of dystrophic changes in the body. The paper evaluates the effect of the concentration of β-hydroxybutyrate and glucose in the blood of new-bodied cows on the indicators of reproductive ability and milk productivity. To do this, venous blood was obtained from cows of different ages after childbirth, where the concentration of glucose and β-hydroxybutyrate was determined. Depending on the level of glucose and ketone bodies, animals were retrospectively differentiated into groups and the severity of economically useful signs was determined. It was found that cows with a glucose level above 3.3 mmol/l required 0.6 more inseminations (P≤0.01), compared with animals whose indicators were in the range of 2.2...3.3 mmol/l. At the same time, the greatest difference in the multiplicity of insemination was present in animals 3...7 lactation (1.2 inseminations per fertilization; P≤0.001). The period from calving to fertilization in cows with a high glucose content was longer by 39.4 days (P < 0.05), while the maximum deviation was found among animals older than the 2nd lactation (by 43.4%; P< 0.05). An increase in the level of β-hydroxybutyrate over 0.7 mmol/l was also accompanied by a deterioration in reproductive function. Thus, the lengthening of the infertility period for all lactation was 21.2 days (P≤0.05). The most pronounced negative effect on reproductive function in ketonemia was observed in first-heifers and cows of the second lactation. So, after the first birth, the lengthening of the period from calving to fertilization was 42.0 days (P < 0.05), and after the second lactation - 29.2 days (P < 0.05). Thus, an increase in the level of glucose and β-hydroxybutyrate in the blood negatively affects, first of all, the reproductive function of cows, and to a lesser extent, the indicators of milk productivity.

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The comparative effects of dietary monensin and propylene glycol on insulin resistance of transition dairy cows

Cited by 8 publications

References 31 publications

Effect of Propylene Glycol on Blood Metabolites, Ruminal and Productive Parameters of Growing-Finishing Lambs

Effect of Propylene Glycol on Blood Metabolites, Ruminal and Productive Parameters of Growing-Finishing Lambs

Effects of Propylene Glycol on Negative Energy Balance of Postpartum Dairy Cows

The effect of the concentration of β-hydroxybutyrate and glucose in the blood on the reproductive function and milk productivity of cows

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