The comparative effects of single intravenous doses of omeprazole and famotidine on intragastric pH

Abe, Yasunobu; Inamori, Masahiko; Togawa, Jun‐Ichi; Kikuchi, Taisuke; Muramatsu, Ken‐ichi; Chiguchi, Gaku; Kawamura, Harunobu; Kobayashi, Noritoshi; Kohno, Hiroyuki; Sakaguchi, Takashi; Takamura, Tomoo; Nakajima, Atsushi; Ueno, Norio; Sekihara, Hisahiko

doi:10.1007/s00535-003-1240-6

Cited by 27 publications

(10 citation statements)

References 31 publications

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“…Although acid inhibition by PPI or H 2 RA treatment differs between H. pylori- negative and H. pylori- positive subjects, few reports have discussed changes in pH during the early phase or the increasing pH value in H. pylori- positive patients [49, 53]. We previously reported the presence of differences between PPI and H 2 RA with regard to their potency and time to acid inhibition in healthy H. pylori- positive subjects.…”

Section: Acid Inhibitory Drugs and Intragastric Phmentioning

confidence: 95%

“…Although PPIs inhibit gastric acid secretion more potently than H 2 RAs overall, PPIs have the disadvantage of exerting relatively weak acid inhibition in the early phase after initial dosing compared with H 2 RAs, which exert their inhibitory effects within a couple of hours of dosing [53]. Indeed, an intravenous infusion of famotidine 20 mg increases pH over 4 h more rapidly than omeprazole 20 mg in H. pylori- negative subjects [54, 55].…”

Section: Acid Inhibitory Drugs and Intragastric Phmentioning

confidence: 99%

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Proton Pump Inhibitor Therapy before and after Endoscopic Submucosal Dissection: A Review

Sugimoto

Jang

Yoshizawa

et al. 2012

Diagnostic and Therapeutic Endoscopy

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Endoscopic submucosal dissection (ESD) is a novel endoscopic procedure first developed in the 1990s which enables en bloc resection of gastric neoplastic lesions that are difficult to resect via conventional endoscopic mucosal resection. However, given that ESD increases the risk of intra- and post-ESD delayed bleeding and that platelet aggregation and coagulation in artificial ulcers after ESD strongly depend on intragastric pH, faster and stronger acid inhibition via proton pump inhibitors (PPIs) and histamine 2-receptor antagonists (H2RAs) as well as endoscopic hemostasis by thermocoagulation during ESD have been used to prevent ESD-related bleeding. Because PPIs more potently inhibit acid secretion than H2RAs, they are often the first-line drugs employed in ESD treatment. However, acid inhibition after the initial infusion of a PPI is weaker in the early phase than that achievable with H2RAs; further, PPI effectiveness can vary depending on genetic differences in CYP2C19. Therefore, optimal acid inhibition may require tailored treatment based on CYP2C19 genotype when ESD is performed, with a concomitant infusion of PPI and H2RA possibly most effective for patients with the rapid metabolizer CYP2C19 genotype, while PPI alone may be sufficient for those with the intermediate or poor metabolizer genotypes.

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Section: Acid Inhibitory Drugs and Intragastric Phmentioning

confidence: 95%

Section: Acid Inhibitory Drugs and Intragastric Phmentioning

confidence: 99%

Proton Pump Inhibitor Therapy before and after Endoscopic Submucosal Dissection: A Review

Sugimoto

Jang

Yoshizawa

et al. 2012

Diagnostic and Therapeutic Endoscopy

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“…Because PPI can block only activated proton pomp, gastric pH does not reflect blood concentration of omeprazole directory. Our previous manuscripts [13-15] reported that after PPI administration, intragastric pH value raise showing up and down.…”

Section: Discussionmentioning

confidence: 99%

Early effect of oral administration of omeprazole with mosapride as compared with those of omeprazole alone on the intragastric pH

et al. 2012

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BackgroundThe ideal medication for acid-related diseases should have a rapid onset of action to promote hemostasis and cause efficient resolution of symptoms. The aim of our study was to comparatively investigate the inhibitory effect on gastric acid secretion of a single oral administration of omeprazole plus mosapride with that of omeprazole alone.MethodsTen Helicobacter pylori-negative male subjects participated in this randomized, two-way crossover study. Intragastric pH was monitored continuously for 6 hours after a single oral administration of omeprazole 20 mg or that of omeprazole 20 mg plus mosapride 5 mg (the omeprazole being administered one hour after the mosapride). Each administration was separated by a 7-days washout period.ResultsThe average pH during the 6-hour period after administration of omeprazole 20 mg plus mosapride 5 mg was higher than that after administration of omeprazole 20 mg alone (median: 3.22 versus 4.21, respectively; p = 0.0247).ConclusionsIn H. pylori -negative healthy male subjects, an oral dose of omeprazole 20 mg plus mosapride 5 mg increased the intragastric pH more rapidly than omeprazole 20 mg alone.

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“…In our study design, we did not try to measure the changes of intragastric pH before and after administration of gastric acid suppressants, but we have previously reported that adequate acid suppression and elevation of the intragastric pH is achieved in the early post-administration phase after a single intravenous administration of gastric acid suppressants 41,42. Although intravenous famotidine had a more rapid onset of action and exerted stronger inhibition of intragastric acid secretion than intravenous omeprazole or lansoprazole in our previous study, there were no significant differences in the gastric emptying rate between the famotidine and omeprazole administration groups in the present study.…”

Section: Discussionmentioning

confidence: 99%

Effects of Histamine-2 Receptor Antagonists and Proton Pump Inhibitors on the Rate of Gastric Emptying: A Crossover Study Using a Continuous Real-Time C Breath Test (BreathID System)

Nonaka¹,

Kessoku²,

Ogawa³

et al. 2011

J Neurogastroenterol Motil

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Background/AimsThe effects of Histamine-2 receptor antagonists and proton pump inhibitors on the gastrointestinal motility have not yet been sufficiently investigated. The aim of this study was to determine the effects of intravenous bolus administration of famotidine and omeprazole on the rate of gastric emptying using the continuous 13C breath test (BreathID system, Exalenz Bioscience Ltd, Israel).MethodsTwelve healthy male volunteers participated in this randomized, 3-way crossover study. After fasting overnight, the subjects were randomly assigned to receive 20 mg of famotidine, 20 mg of omeprazole or 20 mL of saline alone by intravenous bolus injection before a test meal (200 kcal per 200 mL, containing 100 mg of 13C-acetate). Gastric emptying was monitored for 4 hours after the ingestion of test meal by the 13C-acetic acid breath test performed using the BreathID system.ResultsNo significant differences in the calculated parameters, namely, the T1/2, Tlag, GEC, β and κ, were observed among the 3 test conditions.ConclusionsThe study revealed that intravenous administration of gastric acid suppressant drugs had no significant influence on the rate of gastric emptying in comparison with that of saline alone as a placebo. Our results indicating the absence of any effect of either famotidine or omeprazole on accelerating the rate of gastric emptying suggest that both medications can be administered safely to patients suffering from hemorrhagic peptic ulcers who need to be kept nil by mouth from the viewpoint of possible acceleration of gastrointestinal motility in the clinical setting.

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The comparative effects of single intravenous doses of omeprazole and famotidine on intragastric pH

Abstract: In Helicobacter pylori-negative healthy male subjects, an intravenous dose of 20 mg famotidine increased intragastric pH more rapidly than intravenous omeprazole 20 mg.

Cited by 27 publications

References 31 publications

Proton Pump Inhibitor Therapy before and after Endoscopic Submucosal Dissection: A Review

Proton Pump Inhibitor Therapy before and after Endoscopic Submucosal Dissection: A Review

Early effect of oral administration of omeprazole with mosapride as compared with those of omeprazole alone on the intragastric pH

Effects of Histamine-2 Receptor Antagonists and Proton Pump Inhibitors on the Rate of Gastric Emptying: A Crossover Study Using a Continuous Real-Time C Breath Test (BreathID System)

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