The comparative efficacy of 0.12% chlorhexidine and amoxicillin to reduce the incidence and magnitude of bacteremia during third molar extractions: a prospective, blind, randomized clinical trial

DuVall, Nicholas; Fisher, Tommy D.; Hensley, Donna; Hancock, Raymond H.; Vandewalle, Kraig S

doi:10.1016/j.oooo.2012.11.019

Cited by 29 publications

(33 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…NB Duvall, in his comparative in vivo study for bacteriemia after third mo- lar extraction in first group using amoxycilin 2 gr and in second group using CHX mouthwash 0.2% found no statistically significant difference between groups. This increase the possibility of its use in antibacterial prevention compared with the use of systemic antibiotics [12]. Haraji et al in their study which includes 80 patients with bilaterally third molar extraction using CHX gel 0.2% packed to the crest of the alveolar ridge with gelatin sponge, found reduction of dry socket incidence from 32.6% to 11.3%.…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of 1% Chlorhexidine Gel on the Reduction of Dry Socket Occurence Following Surgical Third Molar Extraction— Pilot Study

Ahmedi¹,

Ahmedi²,

Agani³

et al. 2014

OJST

View full text Add to dashboard Cite

Aim & Objectives: The aim of this prospective pilot-study was to assess the efficacy of intra alveolar application of 1% chlorhexidine gel (CHX) on the reduction of dry socket (DS) occurrence following surgical extraction of mandibular third molars. Materials and Methods: A randomized split-mouth-design study included twenty-five patients with bilaterally impacted lower third molars (partial or full bone) requiring full thickness mucoperiastal flap reflection for extraction. Following surgical extraction of third lower molar, 2 ml of gel containing 1% chlorhexidine digluconate (Chlorhexamed ® Gel 1%) were placed in the experimental side, and saline solution was used for irrigation in the control side of extraction sockets, both followed by suturing of extraction site. The surgeries and follow up examinations were performed by the same surgeon. The follow up visits were performed at 48 hours and on day seven, post surgery where presence or absence of dry socket using the Blum criteria for diagnosis was evaluated and pain intensity by Visual Analogue Scale (VAS) 0 -100 was observed. Results: In this pilot study, dry socket was present in 4.0 and 28.0% of cases in the experimental and control groups, respectively (P = 0.048). Fisher's test revealed a statistically significant reduction of dry socket occurrence following the use of 1% CHX gel versus saline solution. Conclusion: The application of CHX gel 1% may significantly reduce the incidence of DS following third molar extraction. Prophylactic use of CHX gel 1% may be suggested in all patients, especially in the patients at risk of development of DS. KeywordsDry Socket; Chlorhexidine 1%; Third Molar Surgery J. Ahmedi et al. 153

show abstract

Section: Discussionmentioning

confidence: 99%

The Efficacy of 1% Chlorhexidine Gel on the Reduction of Dry Socket Occurence Following Surgical Third Molar Extraction— Pilot Study

Ahmedi¹,

Ahmedi²,

Agani³

et al. 2014

OJST

View full text Add to dashboard Cite

show abstract

“…Second, implicit within the term "bloodstream infection" is that the positive blood culture is associated with clinical infection. While most bacteremias are associated with infections, transient bacteremias may occasionally be observed following minor manipulations of nonsterile body surfaces that are not infection associated (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26).…”

Section: Establishing the Presence Of And Defining Community-onset Blmentioning

confidence: 99%

“…Transient bacteremia is a "true" bacteremia in that viable organisms are present in the bloodstream (i.e., not contaminants), but it is not a BSI because it is not infection associated. There are a number of well-recognized causes of transient bacteremia, and these generally involve manipulation of colonized or contaminated mucosal surfaces, including dental manipulations (16)(17)(18)(19), endoscopic gastrointestinal procedures (20)(21)(22)(23), and invasive respiratory procedures (24,25). Transrectal needle prostate biopsy is associated with transient bacteremia in approximately 20% of cases, and this may subsequently evolve into BSI (26).…”

Section: Determining the Significance Of Positive Blood Culturesmentioning

confidence: 99%

Population-Based Epidemiology and Microbiology of Community-Onset Bloodstream Infections

2014

View full text Add to dashboard Cite

SUMMARY Bloodstream infection (BSI) is a major cause of infectious disease morbidity and mortality worldwide. While a positive blood culture is mandatory for establishment of the presence of a BSI, there are a number of determinants that must be considered for establishment of this entity. Community-onset BSIs are those that occur in outpatients or are first identified <48 h after admission to hospital, and they may be subclassified further as health care associated, when they occur in patients with significant prior health care exposure, or community associated, in other cases. The most common causes of community-onset BSI include Escherichia coli , Staphylococcus aureus , and Streptococcus pneumoniae . Antimicrobial-resistant organisms, including methicillin-resistant Staphylococcus aureus and extended-spectrum β-lactamase/metallo-β-lactamase/carbapenemase-producing Enterobacteriaceae , have emerged as important etiologies of community-onset BSI.

show abstract

“…(48) Apesar da administração da amoxicilina no intuito de reduzir complicações pós-operatórias ser objeto de controvérsias, os estudos vigentes revelam que essa prática não apresenta eficácia clínica comprovada e, portanto sua descontinuação deveria ser considerada. (17,45,49,(58)(59)(60)(61)(62)(63) Assim, a melhor forma de prevenir complicações inflamatórias e pós --operatórias permanece sendo o controle vigoroso da cadeia asséptica e a utilização de técnicas cirúrgicas apropriadas. (17,64,65)…”

Section: Discussionunclassified

Administração Profilática De Amoxicilina Em Cirurgias De Terceiros Molares Retidos Em Pacientes Saudáveis: Revisão De Literatura

Pedrosa¹,

Ferro

Pompeu

et al. 2016

J Dent Pub H

View full text Add to dashboard Cite

Background: Impacted third molar surgeries are common procedures in clinical practice of dentists and are associated with several trans and postoperative complications. As a result, antibiotic prophylaxis is quite common. Aim: To investigate the scientific evidences regarding the prophylactic prescription of amoxicillin in third molar surgeries in healthy patients. Methods: It was carried out a literature review in the electronic databases SciELO, PubMed, LILACS, and Oviatt Library from December of 2015 to January of 2016, using as descriptors: amoxicillin, antibiotic prophylaxis, dental surgery, and third molar. Results and Discussion: Prophylactic administration of amoxicillin for third molar extraction is controversial in terms of its effectiveness in preventing post-surgical complications given that the scientific evidences about its advantages and disadvantages are still limited. Conclusion: In third molar extraction of healthy patients, amoxicillin given prophylactically should be carefully prescribed.

show abstract

The comparative efficacy of 0.12% chlorhexidine and amoxicillin to reduce the incidence and magnitude of bacteremia during third molar extractions: a prospective, blind, randomized clinical trial

Cited by 29 publications

References 82 publications

The Efficacy of 1% Chlorhexidine Gel on the Reduction of Dry Socket Occurence Following Surgical Third Molar Extraction— Pilot Study

The Efficacy of 1% Chlorhexidine Gel on the Reduction of Dry Socket Occurence Following Surgical Third Molar Extraction— Pilot Study

Population-Based Epidemiology and Microbiology of Community-Onset Bloodstream Infections

Administração Profilática De Amoxicilina Em Cirurgias De Terceiros Molares Retidos Em Pacientes Saudáveis: Revisão De Literatura

Contact Info

Product

Resources

About