The comparison of amino-terminal probrain natriuretic peptide levels in preeclampsia and normotensive pregnancy

Kale, Ahmet; Kale, Ebru; Yalinkaya, Ahmet; Akdeniz, Nurten; Canoruç, Naime

doi:10.1515/jpm.2005.023

Cited by 46 publications

(37 citation statements)

References 12 publications

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“…In this manner, we compared the impact of preeclampsia prediction of NT-proBNP with notch positivity together with elevated PI values. Unlike in other studies, NTproBNP levels were not different with respect to the development of preeclampsia in later pregnancy [8,13,22]. The lack of difference may be related to some reasons.…”

Section: Discussioncontrasting

confidence: 88%

“…In the present study, NT-proBNP levels were measured during the 21st-24th week. However, Fleming et al and Kale et al [8,13] reported their results after 34-35 weeks. This period is when placentation is completed.…”

Section: Discussionmentioning

confidence: 96%

“…BNP has been investigated in various studies. Kale and colleagues found NT-proBNP levels in preeclamptic women to be prominently higher than those observed in normotensive pregnancies; they concluded that the increase in tension is parallel to the increase in NTproBNP levels and that such high values show the severity of left ventricular diastolic dysfunction [8]. In another study conducted by Fleming et al, normotensive and hypertensive pregnancies were compared, and NT-proBNP levels and left ventricular filling pressure were found to be high in the hypertensive group [13].…”

Section: Discussionmentioning

confidence: 97%

“…This condition leads to water and sodium excretion from the kidneys when increased volume and resistance occur. Studies have shown that N-terminal probrain natriuretic peptide (NT-proBNP) levels increase in cases of preeclampsia, hypertensive pregnancies, twin pregnancies, and pregnancies complicated with pulmonary or cardiac disorders [8][9][10][11]. Previous studies usually focused on patients with preeclampsia and established final and accurate diagnoses.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The value of uterine artery Doppler and NT-proBNP levels in the second trimester to predict preeclampsia

Uyar¹,

Kurt²,

Demirtaş

et al. 2014

Arch Gynecol Obstet

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Section: Discussioncontrasting

confidence: 88%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The value of uterine artery Doppler and NT-proBNP levels in the second trimester to predict preeclampsia

Uyar¹,

Kurt²,

Demirtaş

et al. 2014

Arch Gynecol Obstet

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“…Kale, et al reported that NT-proBNP was significantly higher in pregnant women with pregnancy-induced hypertension with left ventricular diastolic dysfunction than in normotensive pregnant women. 27) Rafik, et al evaluated echocardiograms and NT-proBNP levels and reported that left ventricular diastolic function in pregnant women with pregnancy-induced hypertension was significantly lower than in normal pregnant women. 28) An increase in troponin T concentration in the blood is a biomarker of damaged cardiac muscle cell membrane.…”

Section: Discussionmentioning

confidence: 99%

Detection of Peripartum Myocardial Burden by Vector-Projected 187 Channel Electrocardiography and Serum NT-proBNP

et al. 2013

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SummaryThere is no reliable method of screening for pregnant women at high risk of developing severe myocardial disorders. In this study, we used vector-projected 187 channel electrocardiography (DREAM-ECG) and serum biochemical markers to evaluate peripartum myocardial burden in pregnant women. Forty-one pregnant women were examined at 36-37 weeks gestation (GW36), 7 days postpartum (PPD7), and 1 month postpartum (PPM1). Ten non-pregnant control women were assessed at a single time point. Heart rate, sympathetic index, and repolarization index (RTc dispersion) were quantified using the DREAM-ECG system, and serum levels of NT-proBNP, cardiac troponin T, estrogen, and progesterone were determined. Heart rate and the sympathetic index decreased from GW36 to PPM1 (P = 0.0031). The repolarization index decreased over time and was greater than in non-pregnant controls (31 ± 13 ms). Estrogen and progesterone at PPD7 and PPM1 were significantly lower than those at GW36 (P < 0.0001, P < 0.001). NT-proBNP at PPD7 was greater than at GW36 (median 29 pg/mL at GW36, 86 pg/mL at PPD7), and decreased at PPM1 in comparison to PPD7 (median 18.5 pg/mL). Troponin T was in the normal range during the whole period (< 0.003 ng/mL). In conclusion, these results indicate that the peripartum myocardial burden in pregnant women does not return to normal nonpregnant levels by PPM1. We propose that both repolarization indexes such as RTc dispersion by DREAM-ECG and serum biochemical markers may identify pregnant women at high risk of developing severe myocardial damage in the peripartum period. (Int Heart J 2013; 54: 140-145)

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Genetic Associations of Circulating Cardiovascular Proteins With Gestational Hypertension and Preeclampsia

Schuermans,

Truong,

Ardissino

et al. 2024

JAMA Cardiol

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ImportanceHypertensive disorders of pregnancy (HDPs), including gestational hypertension and preeclampsia, are important contributors to maternal morbidity and mortality worldwide. In addition, women with HDPs face an elevated long-term risk of cardiovascular disease.ObjectiveTo identify proteins in the circulation associated with HDPs.Design, Setting, and ParticipantsTwo-sample mendelian randomization (MR) tested the associations of genetic instruments for cardiovascular disease–related proteins with gestational hypertension and preeclampsia. In downstream analyses, a systematic review of observational data was conducted to evaluate the identified proteins’ dynamics across gestation in hypertensive vs normotensive pregnancies, and phenome-wide MR analyses were performed to identify potential non-HDP–related effects associated with the prioritized proteins. Genetic association data for cardiovascular disease–related proteins were obtained from the Systematic and Combined Analysis of Olink Proteins (SCALLOP) consortium. Genetic association data for the HDPs were obtained from recent European-ancestry genome-wide association study meta-analyses for gestational hypertension and preeclampsia. Study data were analyzed October 2022 to October 2023.ExposuresGenetic instruments for 90 candidate proteins implicated in cardiovascular diseases, constructed using cis-protein quantitative trait loci (cis-pQTLs).Main Outcomes and MeasuresGestational hypertension and preeclampsia.ResultsGenetic association data for cardiovascular disease–related proteins were obtained from 21 758 participants from the SCALLOP consortium. Genetic association data for the HDPs were obtained from 393 238 female individuals (8636 cases and 384 602 controls) for gestational hypertension and 606 903 female individuals (16 032 cases and 590 871 controls) for preeclampsia. Seventy-five of 90 proteins (83.3%) had at least 1 valid cis-pQTL. Of those, 10 proteins (13.3%) were significantly associated with HDPs. Four were robust to sensitivity analyses for gestational hypertension (cluster of differentiation 40, eosinophil cationic protein [ECP], galectin 3, N-terminal pro–brain natriuretic peptide [NT-proBNP]), and 2 were robust for preeclampsia (cystatin B, heat shock protein 27 [HSP27]). Consistent with the MR findings, observational data revealed that lower NT-proBNP (0.76- to 0.88-fold difference vs no HDPs) and higher HSP27 (2.40-fold difference vs no HDPs) levels during the first trimester of pregnancy were associated with increased risk of HDPs, as were higher levels of ECP (1.60-fold difference vs no HDPs). Phenome-wide MR analyses identified 37 unique non-HDP–related protein-disease associations, suggesting potential on-target effects associated with interventions lowering HDP risk through the identified proteins.Conclusions and RelevanceStudy findings suggest genetic associations of 4 cardiovascular disease–related proteins with gestational hypertension and 2 associated with preeclampsia. Future studies are required to test the efficacy of targeting the corresponding pathways to reduce HDP risk.

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The comparison of amino-terminal probrain natriuretic peptide levels in preeclampsia and normotensive pregnancy

Abstract: The higher levels of serum Nt pro-BNP in preeclamptic women may be an indicator of high left-ventricular filling pressure, and indicate left-ventricular diastolic dysfunction.

Cited by 46 publications

References 12 publications

The value of uterine artery Doppler and NT-proBNP levels in the second trimester to predict preeclampsia

The value of uterine artery Doppler and NT-proBNP levels in the second trimester to predict preeclampsia

Detection of Peripartum Myocardial Burden by Vector-Projected 187 Channel Electrocardiography and Serum NT-proBNP

Genetic Associations of Circulating Cardiovascular Proteins With Gestational Hypertension and Preeclampsia

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