The Comparison of Pierre Robin Sequence and Non-Syndromic Cleft Palate

Abstract

Introduction: The aim of this study was to evaluate pre-operative nutritional status, associated syndromes and abnormalities, and post-operative outcomes of patients with Pierre Robin Sequence (PRS) versus those with non-syndromic isolated cleft palate (CIP). Methods: Between January 1995 and December 2013, patients with a cleft palate Veau I-II according to the Veau classification with and without PRS who underwent primary repair were retrospectively analyzed. The nutrition status, age at the time of palatoplasty, additional anomalies, gestational complications, and post-operative speech abnormalities and outcomes were evaluated. Results: A total of 59 patients with PRS (PRS group) and 132 patients without PRS (non-PRS group) were included in the study. Of all patients, 92 were males and 99 were females with a mean age of 14 ± 4.18 (range, 6 to 26) years. The rate of gestational complications, enteral nutrition, complete cleft, additional anomalies, and velopharyngeal insufficiency was significantly higher in the PRS group (P < 0.05). However, the incidence of fistulas and age at the time of palatoplasty did not significantly differ between the groups. Conclusion: Based on our study results, enteral nutrition, respiratory problems, pregnancy complications, velopharyngeal insufficiency, and additional anomalies, but not post-operative palatal fistulas, are more frequently seen in patients with PRS. Although pre-operative care and treatment and rehabilitation in patients with PRS are more complicated than those with the CIP, our experience demonstrates that meticulous repair and follow-up can minimize complications, such as fistulas.

The Influence of Genetic Syndromes on the Algorithm of Cleft Lip and Palate Repair – A Retrospective Study

“…This explains the high rate of pharyngoplasties and tympanostomies in these patients. [7,[17][18][19] The author's findings support these observations. In some previous studies, however, no differences were found between the secondary operations for nonsyndromic patients and patients with PRS.…”

“…The high rate (37.5%) of the secondary operations such as speech improvement surgery and ancillary procedures such as placement of tympanostomy tubes for the SCLP patients is in accordance with the literature. [7,11,[17][18][19] The authors have noted velopharyngeal insufficiency and speech problems as more common conditions in SCLP patients, especially those patients with PRS. This explains the high rate of pharyngoplasties and tympanostomies in these patients.…”

“…The high rate (37.5%) of the secondary operations such as speech improvement surgery and ancillary procedures such as placement of tympanostomy tubes for the SCLP patients is in accordance with the literature. [ 7 11 17 18 19 ]…”

Study on the Effect of Bilateral Mandible Distraction Osteogenesis About the Nutrition Status of Infants With Pierre-Robin Sequence

“…The incidence of feeding difficulties can be up to 91% in patients with PRS (9), and even if the impact of cleft palate is considered, PRS patients are more likely to have eating and breathing problems than children with ordinary cleft palate (10). According to statistics, 45.8% of patients with PRS need enteral nutritional support (11). parenteral nutrition.…”

Ajak- és szájpadhasadékkal társult genetikai szindrómás gyermekek komplex ellátása

“…A legtöbb szerző például azt találta, hogy Robin-szekvenciával született gyermekekben gyakoribb a lágyszájpad-elégtelenség és a következményes orrhangzós beszéd. Ezért ebben a betegcsoportban több szekunder műtét (garatplasztika, timpanoplasztika) elvégzése szükséges [8,11,22,23]. A saját -kis esetszámon alapuló -tapasztalatunk is ezt támogatja.…”