The Comparison of Pro-Oxidant-Antioxidant Balance in Physiologic and Pathologic Jaundice

Boskabadi, Hassan; Ghayour‐Mobarhan, Majid; Bagheri, Fariborz; Pourbadakhshan, Nafiseh

doi:10.5812/ijp.98117

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…[13] In another study, it was shown that a pathological increase in bilirubin levels irrespective of its neurotoxic properties can change the PAB in favor of antioxidants. [14] In asphyxia, it was demonstrated that PAB in combination with hypoxic-ischemic encephalopathy grade might have a better predictive value for the prognosis of asphyxiated babies and predicting future neurologic problems in asphyxiated term infants. [15] There are more data on other oxidative indexes in preterm and term neonates.…”

Section: Discussionmentioning

confidence: 99%

Serum pro-oxidant/antioxidant balance in term versus preterm neonates

2022

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The oxidant/antioxidant status balance is a process that begins before birth and premature infants are particularly susceptible to oxidative stress. According to the mechanisms of oxidative stress and lack of study in this field, in this prospective study, we aimed to compare the levels of serum pro-oxidant/antioxidant balance (PAB) in preterm versus term babies. This was a prospective cross-sectional study that was performed in Ghaem hospital, a university tertiary hospital, in Mashhad, Iran. The study population included all term and preterm neonates who were admitted to the hospital within birth time. In our study, 324 neonates were included. One hundred ninety-eight neonates were preterm (61.1%) and others were term (38.9%). There was a significant difference between PAB levels in term and preterm neonates. Serum PAB level was significantly lower in preterm neonates rather than in term neonates (21.86 ± 21.01 vs 50.33 ± 31.69; P = .001). There was also a significant negative correlation between PAB levels and gestational age. According to previous investigations, we showed for the first time in our study that PAB is lower in preterm newborns rather than in term ones.

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Section: Discussionmentioning

confidence: 99%

Serum pro-oxidant/antioxidant balance in term versus preterm neonates

2022

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“…In a study, it was shown that there was no signi cant relationship between umbilical cord blood pro-oxidant antioxidant's balance and type of delivery [12]. In another study, it was shown that a pathological increase in bilirubin levels irrespective of its neurotoxic properties can change the PAB in favor of antioxidants [13]. In asphyxia, it was demonstrated that PAB in combination with hypoxic-ischemic encephalopathy (HIE) grade might have a better predictive value for the prognosis of asphyxiated babies and predicting future neurologic problems in asphyxiated term infants [14].…”

Section: Discussionmentioning

confidence: 99%

Serum Pro-Oxidant/Antioxidant Balance in Term Versus Preterm Neonates

Boskabadi

Ghayour‐Mobarhan

Saeidinia

2021

Preprint

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Introduction: The oxidant/antioxidant status balance is a process that begins before birth and premature infants are particularly susceptible to oxidative stress. According to the mechanisms of oxidative stress and lack of study in this field, in this prospective study we aimed to compare the levels of serum pro-oxidant/antioxidant balance (PAB) in preterm versus term babies. Methods: This was a prospective cross sectional study that was performed in Ghaem hospital, a university tertiary hospital, Mashhad, Iran. The study population was included of all term and preterm neonates who were admitted to the hospital within birth time. Results: In our study, 324 neonates were included. One hundred ninety eight neonates were preterm (61.1%) and others were term (38.9%). The mean birth weight of participants was 3267.19± 446.35gr in term and 1658.78± 644.97 gr in preterm neonates. There was significant difference between PAB level in term and preterm neonates. Serum PAB level was significantly lower in preterm neonates rather than term neonates (21.86± 21.01 versus 50.33± 31.69; P=0.001). There was also significant negative correlation between PAB levels and gestational age. Conclusion: According to previous investigations, we showed for the first time in our study that PAB is lower in preterm newborns rather than term ones. This is in line with the hypothesis that oxidative stress is higher in preterm neonates.

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Potential Role of Bilirubin in Preventing Retinopathy of Prematurity

Boskabadi

Shoeibi

Bagheri

et al. 2023

CPR

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Background: One of the most common problems in preterm neonates is retinopathy of prematurity (ROP). It has been shown antioxidants may be effective in preventing development and progression of ROP. Considering the antioxidant properties of bilirubin, we decided to investigate the bilirubin level in neonates with ROP and compare it with healthy neonates. Methods: This case-control study was performed on VLBW neonates admitted to the NICU of Ghaem Hospital in Mashhad between 2014-2020 years for Jaundice evaluation. Complete neonate’s characteristics, maternal history and laboratory results were collected in a questionnaire. Then the neonates were examined for ROP by a fellowship of retina of ophthalmologist at 32 weeks or four weeks after birth. The highest bilirubin levels during their hospitalization were also recorded. Results: Of 427 neonates examined, 121 (37.7%) had normal eye examination and 266 (62.3%) had ROP. The mean weight, gestational age and bilirubin were 1455.8± 431.4 gram, 31.6± 2.3 weeks and 8.8 ± 2.4 mg / dl, respectively. There was a significant difference between controls and neonates with ROP with regard to birth weight, duration of intermittent positive pressure ventilation (IPPV), duration of oxygen therapy, first and fifth minute Apgar scores, maximum level of bilirubin and gestational age(P<0.05).It was observed that maximum level of bilirubin was lower in neonates with higher stages of ROP. Conclusion: According to the results of this study, higher levels of bilirubin in neonates may be a protective factor against ROP, Moreover, increased levels of bilirubin is associated with reduced severity of ROP .Therefore, prophylaxis phototherapy in premature infants may need to be reconsidered.

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The Comparison of Pro-Oxidant-Antioxidant Balance in Physiologic and Pathologic Jaundice

Cited by 3 publications

References 23 publications

Serum pro-oxidant/antioxidant balance in term versus preterm neonates

Serum pro-oxidant/antioxidant balance in term versus preterm neonates

Serum Pro-Oxidant/Antioxidant Balance in Term Versus Preterm Neonates

Potential Role of Bilirubin in Preventing Retinopathy of Prematurity

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