The Comparison of Regional RNFL and Fundus Vasculature by OCTA in Chinese Myopia Population

Abstract

Purpose To determine the correlations between peripapillary vessel density, retinal nerve fibre layer (RNFL) thickness, and myopic indices at retina quadrants with optical coherence tomography angiography (OCTA) in Chinese. Methods Fifty-six subjects with a mean spherical equivalent (MSE) of −3.63 ± 0.29 D were included. Peripapillary RNFL thickness and retinal vessel density in four sectors (superior, nasal, inferior, and temporal quadrants) were determined by OCTA, and correlations of the main outcomes were analyzed. Results Negative correlations were found between the peripapillary RNFL thickness and axial length (AL) at superior (r = −0.335, P = 0.001) and inferior (r = −0.551, P < 0.001) quadrants. There was a significant positive correlation with spherical equivalent (SE) at the corresponding quadrants as well as at the nasal quadrant (r = 0.339, P = 0.001; r = 0.379, P < 0.001; and r = 0.209, P = 0.039, resp.). Peripapillary retinal vessel density was also negatively correlated with AL at the nasal quadrant (r = −0.392, P < 0.001), and only at the nasal quadrant, there was a positive correlation between the peripapillary vessel density and SE (r = 0.319, P = 0.001). Conclusions The degree of myopia and elongation of AL were negatively correlated with peripapillary RNFL thickness at superior and inferior quadrants and with peripapillary retinal vessel density at the nasal quadrant.

Ocular Determinants of Peripapillary Vessel Density in Healthy African Americans: The African American Eye Disease Study

“…Greater AL was the other ocular factor associated with lower peripapillary VD in our population, and this finding may provide insight into glaucoma pathogenesis. To date, the negative correlation between AL and peripapillary VD has only been demonstrated in small studies of young myopic patients in China 15,23,39. These findings are consistent with previous reports, which used fluorescein angiography to detect reduced retinal perfusion in myopic eyes 40.…”

“…Strong, positive associations between RNFL thickness and peripapillary VD have been previously reported,23,24 and support the idea that, in general, the quantity of perfused RPCs is proportional to the quantity of RNFL it is supplying 25–27. Prior histology and OCTA studies have demonstrated how RPCs run parallel to the RNFL and that their densities within a given eye are highly correlated 26,28.…”

Changes in Retinal Vasculature and Thickness after Small Incision Lenticule Extraction with Optical Coherence Tomography Angiography

“…The peripapillary RNFL was determined using the optic nerve head protocol. Measurements were automatically performed at four peripapillary quadrants: superior, inferior, nasal, and temporal according to the previous study [19]. We had a single observer to perform the OCTA examination who was blind to the study.…”

Macular vessel density and foveal avascular zone parameters in patients after acute primary angle closure determined by OCT angiography

“…At first reported in 2012, optical coherence tomography angiography (OCTA) is a safer technique to quantitatively assess retinal vasculature than conventional angiography methods 5 – 7 . A number of studies substantiated a significant decrease in peripapillary and macular vessel density (VD) in primary open angle glaucoma (POAG), and normal tension glaucoma (NTG) eyes compared to normal controls 8 – 10 .…”