The compatibility of Tacrine molecule with poly(n-butylcyanoacrylate) and Chitosan as efficient carriers for drug delivery: A molecular dynamics study

Eslami, Mahboobeh; Nikkhah, Sousa Javan; Hashemianzadeh, Seyed Majid; Sajadi, Seyed Abolfazl Seyed

doi:10.1016/j.ejps.2015.11.014

Cited by 44 publications

(19 citation statements)

References 30 publications

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“…The ability to delivery TAC through nanoparticles presents several advantages over the free drug, with enhanced bioavailability, stability, therapeutic effect and lower toxicity [ 36 , 37 , 38 , 39 , 40 ]. In this context, three different NLC formulations loaded with TAC or TAC-MAP were prepared using Compritol 888 ATO, different amounts of Transcutol HP as liquid lipid, and Tween 80 as the surfactant.…”

Section: Resultsmentioning

confidence: 99%

Formulation, Characterization and Evaluation against SH-SY5Y Cells of New Tacrine and Tacrine-MAP Loaded with Lipid Nanoparticles

et al. 2020

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Tacrine (TAC) was the first FDA approved drug for the treatment of Alzheimer’s disease, resulting in increased memory and enhanced cognitive symptoms in patients. However, long-term therapy presents poor patient compliance associated with undesired side effects such as nausea, vomiting and hepatoxicity. To improve its therapeutic efficacy and decrease toxicity, the use of nanoparticles could be applied as a possible solution to delivery TAC. In this context, a project has been designed to develop a new nanostructured lipid carrier (NLC) as a delivery system for TAC and conjugate TAC and model amphipathic peptide (MAP) to decrease TAC limitations. Different formulations loaded with TAC and TAC + MAP were prepared using a combination of Compritol 888 ATO as the solid lipid and Transcutol HP as the liquid lipid component. Physical characterization was evaluated in terms of particle size, surface charge, encapsulation efficiency and in vitro drug release studies. Particle size distributions within the nanometer range were obtained with encapsulation efficiencies of 72.4% for the TAC and 85.6% for the TAC + MAP conjugate. Furthermore, cytotoxicity of all NLC formulations was determined against neuroblastoma cell line SH-SY5Y. The optimized TAC delivery system revealed low toxicity suggesting this could be a potential carrier system to deliver TAC. However, TAC + MAP conjugated even encapsulated in the NLC system demonstrated toxicity against the SH-SY5Y cell line.

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Section: Resultsmentioning

confidence: 99%

Formulation, Characterization and Evaluation against SH-SY5Y Cells of New Tacrine and Tacrine-MAP Loaded with Lipid Nanoparticles

et al. 2020

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“…It has rapid biodegradation and insufficient absorption compared to more hydrophilic and lipophilic molecules [84]. PBCAs are usually targeted to low density lipoprotein (LDL) receptors to make them pass the BBB in mouse and rat models and deliver neural growth factor (NGF) [99] or Tacrine (also delivered by Chitosan carriers) [100] into the CNS as a drug for Alzheimer's and Parkinson's disease therapy.…”

Section: Nanocarriers Nanoparticles and Vectorsmentioning

confidence: 99%

Overcoming the Blood–Brain Barrier. Challenges and Tricks for CNS Drug Delivery

2019

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Treatment of certain central nervous system disorders, including different types of cerebral malignancies, is limited by traditional oral or systemic administrations of therapeutic drugs due to possible serious side effects and/or lack of the brain penetration and, therefore, the efficacy of the drugs is diminished. During the last decade, several new technologies were developed to overcome barrier properties of cerebral capillaries. This review gives a short overview of the structural elements and anatomical features of the blood–brain barrier. The various in vitro (static and dynamic), in vivo (microdialysis), and in situ (brain perfusion) blood–brain barrier models are also presented. The drug formulations and administration options to deliver molecules effectively to the central nervous system (CNS) are presented. Nanocarriers, nanoparticles (lipid, polymeric, magnetic, gold, and carbon based nanoparticles, dendrimers, etc.), viral and peptid vectors and shuttles, sonoporation and microbubbles are briefly shown. The modulation of receptors and efflux transporters in the cell membrane can also be an effective approach to enhance brain exposure to therapeutic compounds. Intranasal administration is a noninvasive delivery route to bypass the blood–brain barrier, while direct brain administration is an invasive mode to target the brain region with therapeutic drug concentrations locally. Nowadays, both technological and mechanistic tools are available to assist in overcoming the blood–brain barrier. With these techniques more effective and even safer drugs can be developed for the treatment of devastating brain disorders.

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“…Moreover, molecular simulation has been considered as a reliable method to investigate the compatibility of polymer blends in recent years. The compatibility of PAM/PVA [18], PEI/PC [19], PLLA/PDLLA/PS/PVPh [20], GAP/DIANP [21], Tacrine/PNBCA/CS [22], IND/PEO/GLU/ SUC [23], PVA/PMMA [24], PLL/PVA [25], CS/PVP [26], PET/PLA [21] and PLA/PEG [27] have been studied. Nevertheless, to our knowledge, the compatibility of PLA/PBS at the molecular level has not been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

The compatibility of polylactic acid and polybutylene succinate blends by molecular and mesoscopic dynamics

Lin

Liu

et al. 2020

International Journal of Smart and Nano Materials

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The compatibility of polylactic acid (PLA)/polybutylene succinate (PBS) blends was studied by molecular dynamics and mesoscopic dynamics, which is a controversial issue in experiments. Six simulation models of PLA/PBS with different composition ratios (100/0, 90/10, 80/20, 70/30, 60/40, 0/100) were constructed. The radial distribution function, hydrogen bond, free energy density, order parameter and iso-density surface morphology of the PLA/PBS systems were simulated and analyzed. Due to the formation of hydrogen bonds and van der Waals bonds between different elements of PLA chains and PBS chains, the PLA/PBS blends exhibit good compatibility at all composition ratios.

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The compatibility of Tacrine molecule with poly(n-butylcyanoacrylate) and Chitosan as efficient carriers for drug delivery: A molecular dynamics study

Cited by 44 publications

References 30 publications

Formulation, Characterization and Evaluation against SH-SY5Y Cells of New Tacrine and Tacrine-MAP Loaded with Lipid Nanoparticles

Formulation, Characterization and Evaluation against SH-SY5Y Cells of New Tacrine and Tacrine-MAP Loaded with Lipid Nanoparticles

Overcoming the Blood–Brain Barrier. Challenges and Tricks for CNS Drug Delivery

The compatibility of polylactic acid and polybutylene succinate blends by molecular and mesoscopic dynamics

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