The research objective is to investigate the impact of organizational culture (OC) based on the Cameron and Quinn model (The Competing Value Framework) on financial performance (FP) in Egyptian hotels. The research used 5 dimensions (occupancy percentage, average of room rate, RevPAR, average of market share, average of revenue) to measure FP in hotels. Quantitative methods were used to achieve the research objective through the questionnaire. A total of 416 questionnaires were provided to general managers, executive managers, HR managers, and quality managers working in four, five-star hotels in Sharm El Sheikh city 104 hotel in Egypt. The research used three main data analysis techniques such as descriptive analysis, correlation, and multi regression by SPSS V25. Empirical findings showed that OC had a positive effect on the FP of hotels. The research recommends hotels in Egypt to attention to the consolidation of OC types, because of their positive impact on enhancing FP of hotels; promoting organizational values such as fairness, equality, teamwork, and cooperation among employees; enhancing the interest of organizational beliefs such as the human element, job satisfaction, increase rewards and incentives.