The complete process of bioresorption and bone replacement using devices made of forged composites of raw hydroxyapatite particles/poly -lactide (F-u-HA/PLLA)

Shikinami, Yasuo; Matsusue, Yoshitaka; Nakamura, Takashi

doi:10.1016/j.biomaterials.2005.02.016

Cited by 211 publications

(168 citation statements)

References 13 publications

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“…In this study, there was no significant difference between the titanium plate, PLLA plate and uHA/PLLA plate. It has been proven that the uHA/PLLA plate produced osteoconductivity in vitro (Shikinami et al, 2005). However, in this study, the finding was that new bone formation surrounding the uHA/PLLA plate was not found in the 3DCT image at1 year postsurgery.…”

Section: Discussioncontrasting

confidence: 63%

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Assessment of bone healing after Le Fort I osteotomy with 3-dimensional computed tomography

Ueki

Miyazaki

Okabe

et al. 2011

Journal of Cranio-Maxillofacial Surgery

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Key words:Bone healing, Pterygoid plate, Le Fort I osteotomy, ultrasonic bone curette, 3-demensional computed tomography (3DCT) AbstractPurpose. The purpose of this study was to examine bone healing after Le Fort I osteotomy in Class III patients.Patients and Methods. The study group consisted of 18 Japanese patients with mandibular prognathism with and without asymmetry, maxillary retrognathism or open bite. A total of 36 sides were examined. Le Fort I osteotomy was performed without a pterygoid osteotome, with an ultrasonic curette used to remove interference at the pterygomaxillary region. Titanium plates (Universal Mid-face fixation module, Stryker, Freiburg, German)were used for four patients, absorbable plates (poly-L-lactic acid (PLLA): NEOFIX®, Gunze, kyoto, Japan) were used for four patients and other absorbable plates (uncalcined and unsintered hydroxyapatite and poly-L-lactic acid (uHA/PLLA): super FIXSORB®MX, Takiron Co. Ltd, Osaka, Japan) were used for ten patients, in the same manner.Postoperative computed tomography (CT) was analyzed for all patients pre-operatively and 1 year post-operative. The anterior and lateral areas between the maxillary segments were measured with 3-dimensional (3D) CT. Bone healing at the pterygomaxillary region was also assessed.Results. There were no significant differences in the area of bone defect healing among the plate types. The areas of bone defect after 1 year were significantly smaller than that immediately after surgery on the right side (p=0.0145) and left side (p=0.0010) in the frontal view and right side in the lateral view (p=0.0118). Bone healing at the pterygo-maxillary junction was found in all cases without artificial pterygoid plate fracture.14 of 22 sides with artificial pterygoid plate fracture by an ultrasonic curette showed bone continuity between the pterygoid plate and posterior part of maxilla.Conclusion. This study suggested that bony healing could occur in spaces between the segments of maxilla and pterygomaxillary regions as well as the region of the anterior and lateral walls in the maxilla, but it is not always complete within 1 year after Le Fort I osteotomy.

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Section: Discussioncontrasting

confidence: 63%

“…Actually, the absorbable plate is weaker than the titanium plate. However, it was proved that PLLA and uHA/PLLA plates were stronger rather than the surrounding cortical bone (Shikinami et al, 2005;Marumo et al, 2006). Furthermore, this study showed that there were no significant differences in the area of bone defect among the plate types.…”

Section: Discussionmentioning

confidence: 63%

Assessment of bone healing after Le Fort I osteotomy with 3-dimensional computed tomography

Ueki

Miyazaki

Okabe

et al. 2011

Journal of Cranio-Maxillofacial Surgery

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“…A biocompatible and biodegradable osteosynthesis membrane (Super-Fixsorb-MX, Takiron, Osaka, Japan), made from composites of uncalcined and unsintered hydroxyapatite (uHA) particles and PLLA, was developed in previous studies and has been clinically applied 25,26) . This material exhibits a mesh-like structure, an elasticity close to that of the natural cortical bone, and high strength during the period required for bone healing, making it superior to unfilled PLLA 24) .…”

Section: Introductionmentioning

confidence: 99%

“…Shikinami et al 26) showed that forged composites reinforced with uHA particles and PLLA were replaced by bone tissue; exhibited bioactivity, bioresorbability, and high mechanical strength; and resulted in a favorable tissue response. In the present study, the uHA/PLLA membranes adhered well to the bone around the defect, without requiring fixation pins.…”

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confidence: 99%

Guided bone regeneration using a hydrophilic membrane made of unsintered hydroxyapatite and poly(L-lactic acid) in a rat bone-defect model

et al. 2018

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The effectiveness of a previously developed unsintered hydroxyapatite (uHA) and poly(L-lactic acid) (PLLA) hydrophilic membrane as a resorbable barrier for guided bone regeneration (GBR) was evaluated. Critical-size 8-mm diameter bone defects were surgically generated in the parietal bones of 24 12-week-old male Wistar rats, which were then divided into three groups in which either a uHA/ PLLA or a collagen membrane or no membrane (control) was placed onto the bone defect. Following sacrifice of the animals 2 or 4 weeks after surgery, bone defects were examined using microcomputed tomography and histological analysis. Bone mineral density, bone mineral content, and relative bone growth area values 2 or 4 weeks after surgery were highest in the uHA/PLLA group. Four weeks after surgery, the relative bone growth area in the uHA/PLLA group was larger than that in the collagen group. The resorbable uHA/PLLA membrane is thus potentially effective for GBR.

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“…The experimental observations, performed on a hybrid Q-ToF instrument, were totally corroborated by a theoretical study involving DFT calculations, molecular mechanics, and molecular dynamics calculations. For instance, biodegradable and biocompatible polymers have been used as biomaterials for various applications such as implant components [1] and bone cements [2]. Such biodegradable polymers are often designed to degrade hydrolytically so that most of the widely studied biodegradable polymers belong to the polyester family and include polylactide (PLA), polyglycolide (PG), and associated copolymers [3].…”

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confidence: 99%

Mechanistic study of the collision-induced dissociation of sodium-cationized polylactide oligomers: A joint experimental and theoretical investigation

Winter

Lemaur

Marsal

et al. 2010

J. Am. Soc. Mass Spectrom.

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The low-kinetic energy collision-induced dissociation (CID) behavior of different sodiumcationized polylactide (PLA) oligomers was thoroughly investigated to shed some light on the analytical potentialities of CID experiments in the context of polymer characterization. Indeed, investigation of several end-groups modified PLA reveals that, in addition to the expected end-group specific dissociations, collisionally-excited PLA.Na ϩ suffer from a backbone cleavage. The so-obtained sodium-bound dimer cations consecutively undergo the loss of a monomeric residue that corresponds to neutral acrylic acid. The experimental observations, performed on a hybrid Q-ToF instrument, were totally corroborated by a theoretical study involving DFT calculations, molecular mechanics, and molecular dynamics calculations. . Such biodegradable polymers are often designed to degrade hydrolytically so that most of the widely studied biodegradable polymers belong to the polyester family and include polylactide (PLA), polyglycolide (PG), and associated copolymers [3]. PLA is certainly one of the most important synthetic biodegradable and biocompatible polymers attracting a huge interest for new and versatile synthetic procedures [4]. Polylactide and poly-(lactic acid) are, respectively, obtained by ring-opening polymerization (ROP) of lactide, the cyclic dimer of lactic acid, or by polycondensation of lactic acid.In the course of our research on the polymerization of lactide using non-organometallic catalysts such as N-heterocyclic carbenes, superbases, fluorinated tertiary alcohols, thiourea derivatives, and phosphazenes [5][6][7], we decided to explore the potential of mass spectrometry to provide an in-depth characterization of synthetic polymers in addition to well-established methodologies, such as gel permeation chromatography (GPC) and nuclear magnetic resonance (NMR). Electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI) represent the most significant recent developments in ionization techniques for mass spectrometry analysis of synthetic polymers [8]. State-of-the-art mass spectrometry tools hold the promise of providing not only absolute molecular mass distributions [9] but also qualitative end-group and repeat-unit composition [10], as well as structural information such as branching and intramolecular ring formation [11]. By definition, MS experiments provide the masses of the individual oligomers prepared during the polymer synthesis. On the basis of the m/z ratio of the detected cationized oligomers, compositional pieces of information such as the number and type of monomer units but also the nature of the incorporated end-groups can be derived. Nowadays, tandem mass spectrometry (MSMS) is emerging as an essential analytical methodology when accurate structural characterization of polymers cannot be unambiguously derived from single-stage MS experiments [12]. Recent MSMS investigations were successfully used to characterize individual functional groups of new polymers, to make

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The complete process of bioresorption and bone replacement using devices made of forged composites of raw hydroxyapatite particles/poly -lactide (F-u-HA/PLLA)

Cited by 211 publications

References 13 publications

Assessment of bone healing after Le Fort I osteotomy with 3-dimensional computed tomography

Assessment of bone healing after Le Fort I osteotomy with 3-dimensional computed tomography

Guided bone regeneration using a hydrophilic membrane made of unsintered hydroxyapatite and poly(L-lactic acid) in a rat bone-defect model

Mechanistic study of the collision-induced dissociation of sodium-cationized polylactide oligomers: A joint experimental and theoretical investigation

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