The complex association between the antioxidant defense system and clinical status in early psychosis

García, Sebastián Moya; Alberich, Susana; Martínez‐Cengotitabengoa, Mónica; Arango, Celso; Castro‐Fornieles, Josefina; Parellada, Mara; Baeza, Inmaculada; Moreno, Carmen; Micó, Juan Antonio; Berrocoso, Esther; Graell, Montserrat; Otero, Soraya; Simal, Tatiana; González‐Pinto, Ana

doi:10.1371/journal.pone.0194685

Cited by 7 publications

(5 citation statements)

References 32 publications

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“…Yet, a direct relationship was found between clinical symptoms and oxidative stress and antioxidant capacity at 6 months. This has been shown in patients with a first episode of psychosis after 6-month follow (40), and in patients with early psychosis after 2-year follow- up (13). However, this association was not observed in other studies based on 11-week follow-up (17), or 6 weeks follow-up (41).…”

Section: Discussionmentioning

confidence: 91%

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Association Between Medication Adherence and Oxidative Stress in Patients With First-Episode Mania

et al. 2019

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Poor adherence is a major problem in patients with manic episodes that impairs functionality and has unknown effects on oxidative stress. The objective of this study was to analyze the relationship between adherence to medication, severity of symptoms and oxidative stress in a sample of patients with a first episode of mania. A longitudinal, 6-month study was performed in 60 patients, who were classified as adherent and non-adherent to medication (mainly antipsychotics). Blood levels of oxidative stress parameters and expression of the antioxidant nuclear transcription factor NRF2 in mononuclear cells of peripheral blood were assessed at baseline and at the end of follow-up. In addition, clinical symptoms and functioning were evaluated. Linear multivariate regression was used to determine the relationship between adherence, oxidative stress, and clinical symptoms. Finally, 44 patients completed follow-up. The results of this study showed that at 6-month follow-up, adherence was significantly associated with better functioning and reduced clinical symptoms. Additionally, more severe symptoms were associated with increased levels of oxidative stress and antioxidant parameters. At study completion, non-adherents exhibited greater levels of antioxidants than adherent patients. In conclusion, poor adherence to medication is associated with a poorer prognosis in the medium term and causes increased antioxidant response.

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Section: Discussionmentioning

confidence: 91%

“…TAS has been proven to be decreased in patients with a first episode of mania (FEM) compared to healthy subjects (12). This parameter, that reflects disbalance in oxidative stress, has been related to worse clinical status of patients (13). In this context, nuclear factor erythroid 2-related factor-2 (NRF2) activity has a relevant role.…”

Section: Introductionmentioning

confidence: 99%

Association Between Medication Adherence and Oxidative Stress in Patients With First-Episode Mania

et al. 2019

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“…Childhood financial stress and parental education may be correlated with how individuals respond to financial stress and current food insecurity, which prior research would suggest may contribute to the onset of psychosis (McCarthy‐Jones, 2017). Moreover, in terms of food insecurity, being unable to feed oneself may result in higher levels of stress, which has been implicated as a risk factor for psychosis via the dysregulation of the Hypothalamic–Pituitary–Adrenal axis (Chaumette et al, 2016) and also via long‐term malnutrition (e.g., deficiencies in Vitamin C, Vitamin E and other carotenoids compounds) (García et al, 2018). However, more research is needed to confirm these pathways.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, in terms of food insecurity, being unable to feed oneself may result in higher levels of stress, which has been implicated as a risk factor for psychosis via the dysregulation of the Hypothalamic-Pituitary-Adrenal axis (Chaumette et al, 2016) and also via long-term malnutrition (e.g., deficiencies in Vitamin C, Vitamin E and other carotenoids compounds) (García et al, 2018). However, more research is needed to confirm these pathways.…”

Section: Social Causationmentioning

confidence: 99%

Economic strain, parental education and psychotic experiences among college students in the United States: Findings from the Healthy Minds Study 2020

Nagendra

Besecker

et al. 2021

Early Intervention Psych

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Aim: Socioeconomic status (SES) is linked to psychosis, and much can be learned by examining how various indicators of SES-specifically economic strain and intergenerational transfer of resources-are related to sub-threshold psychotic experiences among college students.Methods: Using data from the Healthy Minds Survey (September 2020-December 2020), we used multivariable logistic regression models to examine the associations between five SES indicators and 12-month psychotic experiences, adjusting for age, gender and race/ethnicity. We also examined the count of predictors and psychotic experiences.Results: Each indicator of economic strain was associated with greater odds of psychotic experiences. In particular, increasing levels of financial stress (current, childhood and pandemic-related) were associated with greater odds of psychotic experiences in a dose-response fashion. Food insecurity was associated with double the odds of psychotic experiences. In terms of intergenerational transfer of resources, having either one or no parents who attended college was associated with significantly greater odds of having psychotic experiences, when compared with having both parents who attended college. Examining all predictors in the same model, only childhood and current financial stress and food insecurity were significantly associated with psychotic experiences. The count of predictors was significantly associated with greater odds of having psychotic experiences in a dose-dependent fashion.Conclusions: Among college students, economic strain and intergenerational transfer of resources were associated with recent psychotic experiences, highlighting the importance of economic interventions targeting young adults to influence risk for psychosis.

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“…Neurons in the brain are particularly sensitive to OS because of their high lipid content and high metabolic rate [ 7 ]. Several studies have shown that OS is related with the severity of symptoms in SZ patients [ 8 , 9 ]. The antioxidant system can neutralize reactive oxygen species (ROS) by supplying reductive equivalents (electrons) to ROS and reverse oxidative damage in the brain [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Association between MnSOD Activity and Cognitive Impairment in Unmedicated First-Episode Schizophrenia: Regulated by MnSOD Ala-9Val Gene Polymorphism

et al. 2022

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The imbalance between pro-oxidants and antioxidants is thought to be responsible for aging and cognitive impairment in many degenerative diseases, including schizophrenia (SZ). As the first antioxidant enzyme to detoxify superoxide radicals in mitochondria, manganese superoxide dismutase (MnSOD) activity and its functional polymorphism of Ala-9Val have been found to be associated with SZ. In this study, we explored the association between MnSOD activity, MnSOD Ala-9Val polymorphism and cognitive dysfunction in unmedicated first-episode (UMFE) SZ patients, which has not been examined. We recruited 234 UMFE SZ patients and 232 healthy controls (HC) and evaluated them with Repeated Battery for the Assessment of Neuropsychological Status (RBANS), plasma MnSOD activity and MnSOD Ala-9Val (rs4880) polymorphism. In addition, we used the Positive and Negative Syndrome Scale (PANSS) to assess the severity of patients’ psychopathological symptoms. Compared with HC, UMFE patients showed extensive cognitive impairment on RBANS, and had higher MnSOD activity. MnSOD Ala-9Val polymorphism was not associated with SZ susceptibility and cognitive impairment, but only affected MnSOD activity in patients. Moreover, only in SZ patients with Val homozygotes, MnSOD activity was significantly correlated with cognitive impairment, especially in RBANS total score, visuospatial/constructional and attention index scores. Our results suggest that cognitive impairment is associated with MnSOD activity in patients with first-episode SZ, which may be regulated by MnSOD Ala-9Val polymorphism.

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The complex association between the antioxidant defense system and clinical status in early psychosis

Cited by 7 publications

References 32 publications

Association Between Medication Adherence and Oxidative Stress in Patients With First-Episode Mania

Association Between Medication Adherence and Oxidative Stress in Patients With First-Episode Mania

Economic strain, parental education and psychotic experiences among college students in the United States: Findings from the Healthy Minds Study 2020

Association between MnSOD Activity and Cognitive Impairment in Unmedicated First-Episode Schizophrenia: Regulated by MnSOD Ala-9Val Gene Polymorphism

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