The complex landscape of intracellular signalling in protein modification under hyperglycaemic stress leading to metabolic disorders

Khan, Hamda; Khanam, Afreen; Khan, Adnan Ahmad; Ahmad, Rizwan; Husain, Arbab; Habib, Safia; Ahmad, Saheem; Moinuddin,

doi:10.1007/s10930-024-10191-3

Protein J

2024

DOI: 10.1007/s10930-024-10191-3

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The complex landscape of intracellular signalling in protein modification under hyperglycaemic stress leading to metabolic disorders

Hamda Khan,

Afreen Khanam,

Adnan Ahmad Khan

et al.

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2024

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Cited by 2 publications

References 87 publications

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Exploring aldose reductase inhibitors as promising therapeutic targets for diabetes-linked disabilities

Ahmad,

Khan

et al. 2024

International Journal of Biological Macromolecules

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Exploring aldose reductase inhibitors as promising therapeutic targets for diabetes-linked disabilities

Ahmad,

Khan

et al. 2024

International Journal of Biological Macromolecules

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Inhibition of the polyol pathway by Ducrosia anethifolia extract: plausible implications for diabetic retinopathy treatment

Ahmad,

Khan

et al. 2024

Front. Pharmacol.

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IntroductionDiabetic retinopathy is a significant microvascular disorder and the leading cause of vision impairment in working-age individuals. Hyperglycemia triggers retinal damage through mechanisms such as the polyol pathway and the accumulation of advanced glycation end products (AGEs). Inhibiting key enzymes in this pathway, aldose reductase (AR) and sorbitol dehydrogenase (SD), alongside preventing AGE formation, may offer therapeutic strategies for diabetic retinopathy and other vascular complications. This study investigates the ability of Ducrosia anethifolia, an Arabian plant, to inhibit AR and SD enzymes.MethodsMethanolic extracts of the plant were tested in enzyme assays and further analyzed using Lineweaver-Burk plots for kinetic insights. Additionally, the effects on AGE production and sorbitol accumulation in red blood cells were evaluated.ResultsThe methanolic extract showed strong inhibitory effects on AR (IC50: 69.41 ± 3.59 μg/mL) and SD (IC50: 31.11 ± 5.58 μg/mL), acting through a mixed-inhibition mechanism. It also significantly reduced sorbitol accumulation and AGE formation.DiscussionThese findings suggest that the extract’s inhibition of the polyol pathway enzymes is due to its phytochemical content. Further isolation and identification of these active compounds could provide valuable insights for developing future pharmaceutical treatments for diabetic retinopathy.

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The complex landscape of intracellular signalling in protein modification under hyperglycaemic stress leading to metabolic disorders

Cited by 2 publications

References 87 publications

Exploring aldose reductase inhibitors as promising therapeutic targets for diabetes-linked disabilities

Exploring aldose reductase inhibitors as promising therapeutic targets for diabetes-linked disabilities

Inhibition of the polyol pathway by Ducrosia anethifolia extract: plausible implications for diabetic retinopathy treatment

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