The complex link between severity of asthma and rhinitis in mite allergic patients

Antonicelli, Leonardo; Braschi, Maria Chiara; Bresciani, M; Bonifazi, Martina; Baldacci, Sandra; Angino, Anna; Pala, Anna Paola; Viegi, Giovanni

doi:10.1016/j.rmed.2012.09.023

Cited by 13 publications

(11 citation statements)

References 28 publications

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“…In the persistent-asthma group, the nasal symptom scores were significantly higher than in the nonpersistent-asthma group. In some studies asthma severity has been associated with rhinitis severity [7,42] , whereas in others the link between asthma and rhinitis severity has been less clear [9] . In our study, the number of blood eosinophils was increased in asthmatics despite concurrent AR, this being more prominent in the persistent-asthma group.…”

Section: Discussionmentioning

confidence: 99%

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Altered MicroRNA Expression of Nasal Mucosa in Long-Term Asthma and Allergic Rhinitis

Suojalehto¹,

Lindström²,

Majuri³

et al. 2014

Int Arch Allergy Immunol

117

112

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asthmatic patients in comparison to controls. The differences in miRNA expression were mainly similar in asthmatics with and without AR. With regard to asthma severity, a trend of increased miRNA expression in persistent asthma was seen, whereas the downregulation of certain miRNAs was most distinct in nonpersistent-asthma patients. Conclusions: Differences in miRNA expression in the nasal mucosa of subjects with long-term asthma and AR can be seen also when no markers of Th2-type inflammation are detected. Asthma severity had only a minor impact on miRNA expression.

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Section: Discussionmentioning

confidence: 99%

“…The existence and severity of AR have been linked to the severity of the coexisting asthma [6,7] , although some studies have not confirmed this association [8,9] . The inflammatory process in the airways displays several common characteristics in asthma and AR, e.g.…”

mentioning

confidence: 99%

Altered MicroRNA Expression of Nasal Mucosa in Long-Term Asthma and Allergic Rhinitis

Suojalehto¹,

Lindström²,

Majuri³

et al. 2014

Int Arch Allergy Immunol

117

112

View full text Add to dashboard Cite

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“…Indeed, the severity of asthmatic rhinosinusitis was positively related to the number of eosinophils in induced sputum as well as in the peripheral blood [5]. Interestingly, asthma was more severe when chronic rhinosinusitis was also present [13]. Moreover, our present study shows that the occurrence of EOM in asthma patients with chronic rhinosinusitis was dependent on the severity of asthma.…”

Section: Discussionmentioning

confidence: 54%

“…Our total patients showed a relatively high rate (34%) of EOM involvement. This might be explained by the severity of asthma in the patients with chronic rhinosinusitis enrolled in this study having been higher than that in the general asthma patient population, because asthma is more severe when chronic rhinosinusitis is also present [13]. …”

Section: Discussionmentioning

confidence: 99%

Eosinophilic Otitis Media Is Associated with Asthma Severity and Smoking History

Seo

Nonaka²,

Tagaya³

et al. 2015

ORL

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Purpose: Eosinophilic otitis media (EOM) is an intractable otitis media characterized by an accumulation of eosinophils in the middle ear and a strong association with asthma. We investigated the relationship between EOM and asthma severity, asthma risk factors, lung function, and airway structural changes assessed by high-resolution computed tomographic (HRCT) scanning. Materials and Methods: Forty-one asthma patients with chronic rhinosinusitis (18 men and 23 women; mean age 56 years; age range 25-82 years) were included in this study. EOM was diagnosed according to the published diagnostic criteria. Asthma severity and risk factors for asthma, such as smoking history (Brinkman index, BI), were examined. Airway wall thickness and emphysema were assessed with HRCT scanning by a blinded respiratory specialist using a validated method. Lung function was measured using standard procedures. Results: EOM was diagnosed in 34% of the patients. Asthma severity, BI and airway wall thickness were each statistically greater in patients with EOM than in patients without EOM. Conclusion: There was a close relationship between EOM and asthma severity in asthma patients with chronic rhinosinusitis. Cessation of smoking might help prevent EOM by reducing airway wall thickness.

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“…The overlap between allergic and non-allergic upper airways diseases has been discussed in clinical studies, but its epidemiological results remain controversial and poorly defined [13,14,15]. This study aimed to evaluate the prevalence of AR, AR with sinusitis without NP (AR + SsNP) and AR with sinusitis with NP (AR + SwNP), and investigate whether the interaction between AR and bronchial asthma is affected by concomitant upper airway diseases.…”

Section: Introductionmentioning

confidence: 99%

The Heterogeneity Hidden in Allergic Rhinitis and Its Impact on Co-Existing Asthma in Adults: A Population-Based Survey

Antonicelli

Marchetti

Accordini

et al. 2015

Int Arch Allergy Immunol

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Background: It has been suggested that there is some overlap between allergic rhinitis (AR), sinusitis and polyposis, but this has not been fully documented. The present study aimed to evaluate the prevalence of these co-existing diseases and their impact on bronchial asthma in the general population of Italy. Methods: Within the frame of the multicentre Gene Environment Interactions in Respiratory Diseases (GEIRD) study, a postal screening questionnaire including questions about self-reported symptoms of asthma, AR, AR with sinusitis without nasal polyps (AR + SsNP) and AR with sinusitis with nasal polyps (AR + SwNP) was administered. Random samples of subjects aged between 20 and 44 years (n = 5,162) answered the postal questionnaire in 4 Italian centres (Pavia, Sassari, Turin, Verona). In AR subjects, the association among AR only, AR + SsNP, AR + SwNP and bronchial asthma was estimated by the relative risk ratio (RRR) using multinomial regression models. Results: The prevalence of AR in the sample was 25.4% (95% CI 24.2-26.6). A self-reported diagnosis of AR + SsNP and AR + SwNP was reported by 5.7% (95% CI 5.0-6.3) and by 1.2% (95% CI 0.9-1.5) of the subjects, respectively. Current asthma was reported by 17.5% of the AR subjects. In the adjusted multivariate analysis, the risk of having current asthma (RRR = 2.31, 95% CI 1.29-4.15), of having at least 1 asthma attack per year (RRR = 2.30, 95% CI 1.19-4.46) and of having had an emergency department admission for respiratory diseases (RRR = 5.61, 95% CI 1.81-23.92) was higher for subjects with AR + SwNP than subjects with AR only. Conclusions: The diagnosis of AR in the epidemiological setting includes heterogeneous upper airway diseases that affect the clinical features of AR and its interactions with asthma.

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The complex link between severity of asthma and rhinitis in mite allergic patients

Abstract: A link between respective severities of rhinitis and asthma was found in only half of mite allergic patients with rhinitis and asthma.

Cited by 13 publications

References 28 publications

Altered MicroRNA Expression of Nasal Mucosa in Long-Term Asthma and Allergic Rhinitis

Altered MicroRNA Expression of Nasal Mucosa in Long-Term Asthma and Allergic Rhinitis

Eosinophilic Otitis Media Is Associated with Asthma Severity and Smoking History

The Heterogeneity Hidden in Allergic Rhinitis and Its Impact on Co-Existing Asthma in Adults: A Population-Based Survey

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