The complex of zinc bis-(2-methylphenoxyacetate) with tris-2(hydroxyethyl) amine as an activator of synthesis of total tryptophanyl-tRNA synthetase

New atranes and similar ionic complexes. Synthesis, structure, properties

“…( − OOCCH 2 C 6 H 4 ‐Me‐2) 2 , which we named Crezoxyzincatran (CZA), combining the atrane structure, 2‐methylphenoxyacetate anion (the anion of the drug Crezacyn), and the zinc cationin one molecule. The results of biological studies convincingly confirm that the combination of three active structural units in one molecule leads to a significant enhancement of useful properties of the compound, i.e. development of “dual active” principle paves the avenue to “triple active” medicines.…”

“…We have synthesized a vast library (more than 50) of HMA ( 8 ) by the reaction of ТЕА with metal salts МХ m (М = Ca, Mn, Cr, Mo, Fe, Co, Ni, Cu, Cd, Zn, Rh, etc. ; Х = Hal, OAc, OOCСН 2 YAr (Scheme ) …”

“…As a result of multi‐year research, we have synthesized about 300 atranes (silatranes, hydrometallatranes, protatranes, metallprotatranes, aroxyprotatranes and similar ionic complexes) from three pharmacophoric components, biogenic ethanolamines (and other amines), biologically active acids and essential metals …”

“…It has been shown that the combination of two or more bioactive components in one molecule can ensure their synergistic effect . The compounds obtained are promising substances for agriculture, pharmacology, medicine, microbiology and biotechnology …”

Reaction of pharmacological active tris-(2-hydroxyethyl)ammonium 4-chlorophenylsulfanylacetate with ZnCl2 or NiCl2: first conversion of a protic ionic liquid into metallated ionic liquid

“…Recently we have shown that metallated ionic liquid tris-(2-hydroxyethyl)amine-bis-(2-methylphenoxyacetate)zinc N(CН 2 СН 2 ОН) 3 Zn 2+ · 2( - ООССН 2 OC 6 H 4 -Me-2) exhibits a pronounced anti-sclerotic effect [22]. …”