: In this review, we examine ‘greener’ routes to nanoparticles of iron oxides, in the recent years; nanotechnology has emerged as a state-of-the-art and cutting edge technology with multifarious applications in a wide array of fields. Natural products or extracted from natural products. Such as different plant extracts, have been used as reductants, and as capping agents during synthesis. A very easy, efficient and environment-friendly protocol was developed to synthesize green nanoparticles (NPs) with an aqueous extract of various plant, phenolic compounds extracted from plants play a major role as a non-toxic reducing and capping agents for nanoparticle. Nanoparticles and their compounds are known to exert a strong inhibitory and microbial activity on bacteria, viruses, and fungi. In today's world, because of the epidemic of infectious diseases caused by different pathogenic bacteria and the development of antibiotic resistance. Green synthesis, characterization, and application of nanoparticles (NPs) are becoming an important challenge in nanotechnology. Green synthesis of nanoparticles is made in large quantities worldwide for a wide range of applications. This technique is very safe and environmentally friendly.

Data on the pharmacological activity of trecrezan -a new domestic adaptogen and immunomodulator -are presented. A brief history of the drug creation, the chemical structure, and the immunostimulant and antistressor effects are considered. Trecrezan is recommended for complex therapy of patients with myocardial infarction, hepatitis, radiation-induced diseases, and pancreonecrosis. The administration of trecrezan stimulates proliferative and reparative processes, thus offering good prospects in surgical practice for the accelerated healing of purulent-necrotic disorders and postoperation wounds.

The results of an experimental and clinical study on the pharmacological properties of new compounds representing tris-(2-hydroxyethyl)ammonium salts (TES) of arylheteroacetic acids -in particular, tris-(2-hydroxyethyl)ammonium-2-methylphenoxyacetate (trecrezan) -are summarized. Trecrezan exhibits a modulating action on immunity and hemopoiesis and offers a promising approach to immune correction for the treatment of immune deficiency and autoimmune disorders. Recovery of the proliferative activity of the early precursors of erythropoiesis with the aid of trecrezan (experimental model) leads to the normalization of immunity and hemopoiesis. A method involving trecrezan administration has been developed for the complex treatment of acute viral hepatitis B as well as hepatitis A and B complicated by occupational anamnesis. Trecrezan has also been successfully applied for the complex treatment of ischemic heart disease and multiple sclerosis. Trecrezan stimulates the regeneration of hepatocytes during partial hepatectomy and acts as an effective adjuvant in the complex therapy of tuberculosis. Trecrezan analogs (TES) show antitumor, hepatoprotective, and adaptive activity, increase the resistance of animals to oxygen insufficiency and to poisoning with heavy metal salts and organophosphorus compounds, and improve the endurance of animals under physical load and emotional stress conditions. EXPERIMENTAL DATA Immunomodulating effect. Trecrezan possesses pronounced immunomodulating properties. Tests on intact mice 244 0091-150X/07/4105-0244

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