Pharmacological activity and clinical effects of trecrezan and other tris-(2-hydroxyethyl)ammonium salts of arylheteroacetic acids (A review)

Abstract

The results of an experimental and clinical study on the pharmacological properties of new compounds representing tris-(2-hydroxyethyl)ammonium salts (TES) of arylheteroacetic acids -in particular, tris-(2-hydroxyethyl)ammonium-2-methylphenoxyacetate (trecrezan) -are summarized. Trecrezan exhibits a modulating action on immunity and hemopoiesis and offers a promising approach to immune correction for the treatment of immune deficiency and autoimmune disorders. Recovery of the proliferative activity of the early precursors of erythropoiesis with the aid of trecrezan (experimental model) leads to the normalization of immunity and hemopoiesis. A method involving trecrezan administration has been developed for the complex treatment of acute viral hepatitis B as well as hepatitis A and B complicated by occupational anamnesis. Trecrezan has also been successfully applied for the complex treatment of ischemic heart disease and multiple sclerosis. Trecrezan stimulates the regeneration of hepatocytes during partial hepatectomy and acts as an effective adjuvant in the complex therapy of tuberculosis. Trecrezan analogs (TES) show antitumor, hepatoprotective, and adaptive activity, increase the resistance of animals to oxygen insufficiency and to poisoning with heavy metal salts and organophosphorus compounds, and improve the endurance of animals under physical load and emotional stress conditions. EXPERIMENTAL DATA Immunomodulating effect. Trecrezan possesses pronounced immunomodulating properties. Tests on intact mice 244 0091-150X/07/4105-0244

Contribution of the Scientific School of Academician M.G. Voronkov to the Development of the Chemistry of Biologically Active Atranes (Protatranes and Hydrometallatranes) (A Review)

“…It is applicable in the prevention of oncological diseases and in the correction of the psychoemotional status of narcological patients [ 34 ]. Trecresan is also efficient in the complex treatment of tuberculosis and can be used in the case of heavy somatic pathology [ 41 ]. Trecresan can be used as an efficient drug in the complex system of the methods for the prevention and treatment of coronavirus infection aftereffects, including these related to bronchopulmonary pathology [ 42 ].…”

Triethanolammonium salicylate — Protic alkanolammonium ionic liquid

“…It is known that salicylic acid is widely used in cosmetology and medicine due to its antiseptic action. Based on the papers [14][15][16][17][18], it can be expected that triethanolammonium salicylate would have a similar effect. We …”

“…A number of studies have shown [14][15][16][17][18] that many protatranes have biological activity, which is mainly determined by the atrane structure of the cation and the nature of an anion. The first compound of this class was triethanolammonium salt of 2-methylphenyloxyacetic acid [2-CH 3 C 6 H 4 OCH 2 COO] -[NH(CH 2 CH 2 OH) 3 ] + (trecrezan), which is a drug of wide spectrum of action (adaptogen, immunomodulator, etc.)…”

“…The first compound of this class was triethanolammonium salt of 2-methylphenyloxyacetic acid [2-CH 3 C 6 H 4 OCH 2 COO] -[NH(CH 2 CH 2 OH) 3 ] + (trecrezan), which is a drug of wide spectrum of action (adaptogen, immunomodulator, etc.) [17,18].…”

The complex of zinc bis-(2-methylphenoxyacetate) with tris-2(hydroxyethyl) amine as an activator of synthesis of total tryptophanyl-tRNA synthetase

“…Crezoxyzincatran is an analogue of Tris 2(hydroxyethyl)ammonium 2 methylphenoxyacetate, an adaptogen and immunomodulator trecrezan. Trec rezan, similarly to many triethanolammonium salts of aroxyacetic acids, reduces the injury of elastic fibers, stabilizes cell membranes, and has a good biocompat ibility [5][6][7]. The detection of activation of TrpRS will make it possible to elucidate the molecular mecha nisms of action of CZA on the expression of TrpRS at various levels, including at the level of mRNA.…”