The complexity of an overlap type resistant cryoglobulinemia: a case report and review of the literature

Tocut, Milena; Rozman, Ziv; Biro, Alexander; Winder, Asher; Tanay, Amir; Zandman‐Goddard, Gisele

doi:10.1007/s10067-018-04423-y

Cited by 6 publications

(6 citation statements)

References 25 publications

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“…Fifty out of the 56 cases (89.3%) corresponded to vasculitis secondary to an immunological process (Table 3 ) [ 11 – 60 ]. Among these 50 cases, 44 (88.0%) corresponded to primary vasculitis, 4 were secondary to Systemic Lupus Erythematosus [ 26 , 41 , 50 , 60 ], 1 to cryoglobulinaemia [ 14 ] and 1 to cryoglobulinaemia associated with inflammatory bowel disease [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

“…Among these 50 cases, 44 (88.0%) corresponded to primary vasculitis, 4 were secondary to Systemic Lupus Erythematosus [ 26 , 41 , 50 , 60 ], 1 to cryoglobulinaemia [ 14 ] and 1 to cryoglobulinaemia associated with inflammatory bowel disease [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

“…Among the 44 primary vasculitis diagnosed in the post-partum period, the first symptom occurred before delivery in 26 cases (59.1%) [ 11 , 15 , 17 – 20 , 27 , 30 , 32 – 35 , 38 – 40 , 42 , 43 , 45 , 47 , 48 , 52 , 54 , 56 – 58 , 60 ]. Among the 6 vasculitis secondary to Systemic Lupus Erythematosus and cryoglobulinaemia [ 14 , 26 , 34 , 41 , 50 , 60 ], the first symptom of vasculitis occurred before delivery in 2 cases only (33.3%) [ 34 , 60 ]. There was no pregnancy complications in 11 out of the 28 (39.2%) vasculitis cases secondary to an immunological process (primary and secondary) whose first symptom occurred before delivery and in 11 out of 22 (50.0%) vasculitis cases secondary to an immunological process (primary and secondary) whose first symptom occurred after delivery.…”

Section: Resultsmentioning

confidence: 99%

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Systemic vasculitis diagnosed during the post-partum period: case report and review of the literature

Demotier

Orquevaux

N’Guyen

2023

matern health, neonatol and perinatol

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Introduction The vasculitis diagnosed specifically in the post-partum period are less well known. We report here such a case followed by a descriptive review of the literature. Case report A 25 year-old French nurse reported abrupt-onset musculoskeletal pain 15 days after delivery of her first infant. Her first pregnancy was uneventful. The physical examination yielded only bilateral conjunctivitis and purpuric eruption of lower limbs, and complementary investigations evidenced pulmonary renal syndrome in connection with the diagnosis of Granulomatosis with Polyangiitis. Methods We screened previous articles in Medline database using keywords (i) “post-partum” or “puerperium” (ii)”peripartum” (iii) “pregnancy” associated with “vasculitis”. Full texts were obtained from case reports or cases series whose title or abstract included keywords of interest (or synonyms). These references were secondarily excluded if the diagnosis of vasculitis was not confirmed or made before or more than 6 months after delivery and if vasculitis occurred only in the new born or affected only the cerebral vasculature or the retina. Results Fifty-six cases of vasculitis diagnosed in the post-partum period were included, 50 (89.3%) were secondary to an immunological process and 44 corresponded to primary vasculitis, 4 were secondary to Systemic Lupus Erythematosus, 1 to cryoglobulinaemia and 1 to cryoglobulinaemia associated with inflammatory bowel disease. The main primary vasculitis diagnosed were Takayasu Arteritis (n = 10), Eosinophilic granulomatosis with polyangiitis (n = 9), Granulomatosis with Polyangiitis (n = 7), Periarteritis Nodosa (n = 5) and Behcet’s disease (n = 4). The first symptom occurred before delivery in 26 (59.1%) and maternal death occurred in 4 (9.1%) out of the 44 primary vasculitis cases. Conclusion The vasculitis diagnosed in the post-partum period were mainly primary vasculitis among patients in whom the diagnosis had not been made during pregnancy. In less than half of cases and as described in ours, there were no reported symptoms before delivery. Therefore, the physicians should pay attention to symptoms and keep a high degree of suspicion for vasculitis before as well as after delivery.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Systemic vasculitis diagnosed during the post-partum period: case report and review of the literature

Demotier

Orquevaux

N’Guyen

2023

matern health, neonatol and perinatol

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“…Essential mixed cryoglobulinemia is associated with infections, malignancy, and autoimmune diseases, but may be idiopathic [ 96 ]. Up to 90% of reported cases are associated with hepatitis C (HCV) infection, and as such it is omitted from Figure 2 .…”

Section: Resultsmentioning

confidence: 99%

Autoimmune Disease Classification Based on PubMed Text Mining

Samuels

Malov

Saha

et al. 2022

JCM

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Autoimmune diseases (AIDs) are often co-associated, and about 25% of patients with one AID tend to develop other comorbid AIDs. Here, we employ the power of datamining to predict the comorbidity of AIDs based on their normalized co-citation in PubMed. First, we validate our technique in a test dataset using earlier-reported comorbidities of seven knowns AIDs. Notably, the prediction correlates well with comorbidity (R = 0.91) and validates our methodology. Then, we predict the association of 100 AIDs and classify them using principal component analysis. Our results are helpful in classifying AIDs into one of the following systems: (1) gastrointestinal, (2) neuronal, (3) eye, (4) cutaneous, (5) musculoskeletal, (6) kidneys and lungs, (7) cardiovascular, (8) hematopoietic, (9) endocrine, and (10) multiple. Our classification agrees with experimentally based taxonomy and ranks AID according to affected systems and gender. Some AIDs are unclassified and do not associate well with other AIDs. Interestingly, Alzheimer’s disease correlates well with other AIDs such as multiple sclerosis. Finally, our results generate a network classification of autoimmune diseases based on PubMed text mining and help map this medical universe. Our results are expected to assist healthcare workers in diagnosing comorbidity in patients with an autoimmune disease, and to help researchers in identifying common genetic, environmental, and autoimmune mechanisms.

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“…Despite therapy with cyclophosphamide, rituximab, plasmapheresis, and dialysis, the patient died after 8 months. It seems that an overlapping entity of type I and II cryoglobulinemia with severe multi-organ involvement is rare and usually resistant to most available therapies and is fatal[8]. Immune checkpoint inhibitor (ICI)-induced myositis is a newly emerging systemic inflammatory myopathy following the administration of ICI.…”

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confidence: 99%