2017
DOI: 10.1371/journal.pone.0179015
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The composition of T-cell subsets are altered in the burn wound early after injury

Abstract: Background

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Cited by 31 publications
(24 citation statements)
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“…In our opinion the findings reveal a predominantly anti-apoptotic effect of the drug on thymus cells on the background of thermal damage to the skin. The realization of this effect over a long period of development of burn disease potentially must reduce the clinical manifestations of damage to this organ, which were documented in numerical experimental studies [17,22,23] in the early and delayed periods of this pathology. The use of HAES-LX-5% produces a positive polyfactor effect on the DNA content in adenohypophysis, thymus and adrenal cells.…”
Section: Dynamics Of S-phase Indices (%) Of Adenohypophysis Adrenal mentioning
confidence: 98%
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“…In our opinion the findings reveal a predominantly anti-apoptotic effect of the drug on thymus cells on the background of thermal damage to the skin. The realization of this effect over a long period of development of burn disease potentially must reduce the clinical manifestations of damage to this organ, which were documented in numerical experimental studies [17,22,23] in the early and delayed periods of this pathology. The use of HAES-LX-5% produces a positive polyfactor effect on the DNA content in adenohypophysis, thymus and adrenal cells.…”
Section: Dynamics Of S-phase Indices (%) Of Adenohypophysis Adrenal mentioning
confidence: 98%
“…Histological, immunological and biochemical manifestations of adenohypophysis [2], adrenal glands [10,18] and thymus [13,28] damages have been established at different times in the course of burn disease, which lead to severe organ damage [23,22]. However, the molecular mechanisms of these disorders remain poorly understood, which makes it difficult to develop pathogenetic treatments for burn disease.…”
mentioning
confidence: 99%
“…65 One might hypothesise that true added toxicities might especially arise when this state is disrupted, in the case of injury or autoimmune disorders. 66,67 Such patients will need to be excluded from the first clinical trials dealing with chemokine-receptor-transduced T cells. Along the same lines, T cells will naturally utilise endogenously expressed chemokine receptors to traffic, and this process might compete with the newly introduced receptor.…”
Section: Improvement Of T Cell Trafficking To Solid Tumoursmentioning
confidence: 99%
“…Contrary to γδ T cells, αβ T cells, another T-cell subset, play an important role in transition from the inflammatory to tissue maturation/remodeling phase of wound healing. αβ T cells produce Th2 cytokines (e.g., IL-4, IL-5, IL-6, IL-9, IL-10 and IL-13) attenuating early inflammatory response by suppression of myeloid cell activation and myeloid suppressor cell recruitment [ 63 ], thus promoting Th2 polarization of T-cell subsets in WME. In normally healing wounds, the Th1 polarized T cells were shown to be predominantly present [ 64 ].…”
Section: Inflammatory Phase Of Wound Healingmentioning
confidence: 99%