As a consequence of nascent technology, the 19th century witnessed a profound change in orientation to the nervous system. For example, improved microscopy in the first half of the 19th century allowed high magnification without blurring. The subsequent observation of nucleated cells led to the identification of individual brain cells. Philosophical changes in approach to the natural sciences took their lead from those applied to physical observations. The Ukrainian anatomist and histologist, Vladimir Alekseyevich Betz (1834-94) played a pivotal role in reshaping scientific and philosophical approaches to the brain, connecting cerebral localization, function and brain microstructure. Betz revolutionized methods of cell fixation and staining. Sometimes his efforts yielded enormously complicated technological improvements. Betz's greatest contribution, however, was connecting his discovery of the function of giant pyramidal neurons of the primary motor cortex ('cells of Betz') with the cortical organization. Considering cortical cytoarchitectonics in relation with physiological function, Betz recognized this organization in two areas: motor and sensory. He defined a functional area on histological grounds and thereby opened the way to study precise cortical areas. Betz participated in the scientific transformation of cytoarchitectonics based on macro- and microscopic studies of the cortical surface, enabling him to view the paths of nerve cells in the brain. Betz's influence allowed systemization of scattered scientific findings. The discovery of pyramidal cells was a turning point in the prevailing philosophical and scientific approach to the brain, linking cytoarchitecture, neurophysiology and cerebral localization.

In spite of the existence of numerous developed methods of cephalometric analysis, which should help to choose the right direction of orthodontic treatment, usually the doctor has to act intuitively, based on his experience, because their development didn’t take into account numerous factors (ethnicity, age, gender, etc.). Improving these techniques, considering the above-mentioned factors, would significantly increase their effectiveness, and hence the quality of providing dental care to the population. The purpose of the work is to construct and analyze a regression model of teleroentgenographic indicators used in the method of C. J. Burstone in young men and women with normal occlusion close to orthognathic bite and harmonic face. Primary side teleroentgenograms of 38 young men (aged 17-21 years) and 55 young women (aged 16-20 years) with normal occlusion close to orthognathic bite and harmonic face, obtained from the Veraviewepocs 3D device, Morita (Japan), taken from the bank data of research center of National Pirogov Memorial Medical University, Vinnytsya. Cephalometric measurements were performed according to the recommendations of C. J. Burstone. All indicators were divided into three groups: 1 - metric characteristics of the skull, which usually do not change during surgical and orthodontic treatment; 2 - indicators of the tooth-jaw system, the definitions of which most often need to be guided by the orthodontic treatment of growing patients and orthodontic surgery, which allows people with already formed bone skeleton to change the width, length, angles and position of the bones of the upper and lower jaws; 3 - indicators that actually characterize the position of each individual tooth relative to each other, to the bony cranial structures and face profile. Regression models of individual teleroentgenographic indicators used in the method of C. J. Burstone, built using the licensed package “Statistica 6.0”. Constructed all 6 reliable models of indicators included in the second group (anterior lower facial height ANS-Gn/Me, maxillary length ANS-PNS, ramus length Ar-Go, mandibular length Go-Pog, anterior upper facial height N-ANS and posterior upper facial height PNS-N) depending on the indicators of the first group (posterior section of cranial base Ar-Pt, anterior skull base length N-CC, angle of the cranial tilt POr-NBa, anterior section of cranial base Pt-N and distance P-PTV); as well as all 7 reliable models of indicators included in the third group (distances 1u-NF, 1l-MP, 6u-NF, 6l-MP and angles OP-HP, Max1-NF/Max1-SpP, Mand1-Mp/Mand1-MeGo) depending on the indicators of the first and second (distance A-B, A-NPog, Gо-CF, Max-Mand, N-A, N-B, N-Pog and Xi-Pm and angles MeGo-NPog, MP-HP, NAPog, N-ANS-Pog, N-CF-A, NPog-POr, POr-CFXi і POr-ANSPNS) groups. It was established that in young men the model of telerentgenographic indices included in the second group depending on the indicators of the first group and included in the third group, depending on the indicators of the first and second groups, have a higher determination coefficient than in young women (R2 from 0.806 to 0.918 in young men and from 0.510 to 0.768 for young women, and from 0.750 to 0.993 for young men and from 0.510 to 0.986 for young women). In the analysis of entering into the regression models of the relevant predictors found that in young men among the teleroentgenographic indicators of the first group included in the models of indicators of the second group most often included - distances P-PTV (33.3%), Pt-N and N-CC (by 25.0%); and in young women– distances N-CC (38.5%) and P-PTV (30.8%). It was also found that among young men among the teleroentgenographic indicators of the first and second groups that were included in the models of the third group of indicators most often included - distance ANS-Gn/Me (12.8%), the magnitude of the angles NAPog, POr-CFXi and POr-ANSPNS (by 9.4%); and in young women– distance ANS-Gn/Me (13.2%), distances А-В and PNS-N and the magnitude of the angle NAPog (by 7.9%).

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The scientific literature presents quite a large number of works, in which the priority role of mathematical modeling in providing high-quality medical care, health and active longevity of a person is determined. The purpose of the work is to construct and analyze the regression models of individual sonographic sizes of kidneys in practically healthy women of the middle intermediate somatotype, depending on the features of the anthropometric and somatotypological indicators. Within the framework of the agreement on scientific cooperation from the database of National Pirogov Memorial Medical University, Vinnytsya primary sonographic parameters (length, width, anterior-posterior dimension, area of longitudinal and cross-section of the kidneys and their sinuses, as well as volume of the right and left kidneys) and anthropometric indices (obtained by the method of V.V. Bunak in the modification of P.P. Shaparenko) of 17 practically healthy women of the first mature age of the middle intermediate somatotype, who in the third generation live in the Podillya region of Ukraine. The construction of regression models of individual sonographic sizes of the kidneys, depending on the features of anthropo-somatotypological parameters of the body of women of the middle intermediate somatotype, was carried out in the licensed package “Statistica 6.1”. In women of the middle intermediate somatotype all 16 possible reliable regression models of sonographic parameters of the kidneys were constructed depending on the anthropo-somatotypological parameters with the determination coefficient R2 from 0.891 to 0.978. The analysis of reliable regression models (with a coefficient of determination greater than 0.6), the sonographic parameters of the kidneys in practically healthy women of the middle intermediate somatotype revealed that most often models of both kidneys, as well as separately of the right and left kidneys, include the circumferential dimensions of the body (respectively, 35.9 – 33.3 – 38.5% of the total number of indicators included in the models). In addition, models of both kidneys most often include cephalometric indices (12.6%), thickness of skin-fat folds and body diameters (by 11.7%); models of the right kidney – body diameters (15.7%), cephalometric indices and width of distal epiphyses of long tubular bones of extremities (by 11.8%); models of the right kidney - the thickness of skin and fat folds (17.3%) and cephalometric indices (13.5%). Attention is drawn to the lack of entry into models of sonographic sizes of kidneys total body sizes.

The work is devoted to the study of structural changes of enterocytes in the mucous membrane of the duodenum in a burn injury of the skin of a rat under conditions of experimental streptozotocin induced diabetes. The study was carried out on laboratory white adult rats-males weighing 180-210 g. The control group consisted of 21 animals without somatic pathology, the first experimental group consisted of 21 rats with skin burn injury, the second experimental group cleared 21 rats with skin burn and experimental streptozotocin induced diabetes. A model of experimental diabetes mellitus was reproduced by administering streptozotocin intraperitoneally once in dose of 50 mg/kg to rats. In an experimental simulation of a skin burn, two copper plates in the form of an ellipse were kept in water at 100oC for 10 minutes and, under ether anesthesia conditions, were applied simultaneously symmetrically on both exposed parts of the body of rats with an exposure for 10 seconds. Burn skin damage in rats was II-AB degrees – dermal surface burn (according to the old classification III-A degree) with a total area of 21-23% of the body surface with the development of burn shock. For morphological studies, the duodenum was taken, fragments of which were processed using conventional light and electron microscopy. The main criteria for assessing damage the enterocytes of the duodenal mucosa were the results studies of histological and ultrastructural data over 7, 14 and 21 days after a skin burn. The results of the studies showed that the damage of the enterocytes of the duodenal mucosa is based on deep destructive changes, which after 21 days (at the stage of septic toxemia), as a rule, are not reversible and develop against the background of significant intoxication of the organism. In the mucous membrane of the duodenum with burn injury of the skin associated with diabetes mellitus, there is a deterioration of the manifestations of the adaptive response and prolongation of destructive processes, accompanied by a violation of intercellular interactions in cytoarchitectically modified and deformed villi and crypts.