“…More than ten years ago, in co-operation with the Institute of Measuring Techniques, Faculty of Electrical Engineering, and Department of ENT at the University of Technology Aachen, both an arm-based, mechanical navigation system and already a prototype version of an optical, infrared-based system were developed [15]. The armbased CAL system was routinely used in selected neurosurgical procedures from 1990 until 1995, while the prototype optical system was only applied for a few experimental surgical cases [11,15] at the Technical University of Aachen. Since 1995 the 3D optical navigation system EasyGuide (Philips Medical Systems, Best, The Netherlands) was routinely used in Aachen [16].…”