In the presented work, the literature data on the influence of various environmental factors were analyzed on the formation of silver nanoparticles by yeast strains. It was determined that the optimal conditions for the synthesis of silver nanoparticles by the yeast strain Saccharomyces ellipsoideus BSU-XR1 were on the 21st day of incubation, on 4-6 days of incubation in different strains of Saccharomyces cerevisiae, and between 2-10 days in Candida strains. The optimal amount of wet biomass was between 8 and 10 g for Candida strains and 10 g for Saccharomyces strains. The temperature limit for Saccharomyces was observed at 25-35°C, and for Candida at 25-37°C. For strains, synthesis of silver nanoparticles was optimal in the pH range of 4-10, and pH range of 7 for Candida strains. Depending on the concentration of AgN03 salt, the optimal synthesis of silver nanoparticles occurred at concentrations of 0.5 and 1 mM for Saccharomyces, and 1 mM for Candida. The optimal incubation conditions for both sexes were under dark environment.