The concentration of TNF‐α correlate with number of inflammatory cells and degree of vascularization in radicular cysts

Jurišić, Vladimir; Terzić, Tatjana; Colic, Snjezana; Jurišić, Milan

doi:10.1111/j.1601-0825.2007.01426.x

Cited by 64 publications

(54 citation statements)

References 21 publications

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“…Our data suggest higher values of CRP and TNF-α in DMT1 patients with developed microangiopathy in regard to DMT1 patients without microvascular complications. That fact is in accordance with literature data which indicate that higher value of infl ammatory cytokines correlates with microvascular and macrovascular damage [13][14][15][16][17].…”

Section: Discussionsupporting

confidence: 82%

Markers of inflammation and microvascular complications in type 1 diabetes

et al. 2014

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Section: Discussionsupporting

confidence: 82%

Markers of inflammation and microvascular complications in type 1 diabetes

et al. 2014

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“…The quantitative microscopic analysis was performed according to the method described by Jurisic et al 8 Each specimen was graded under 400× magnification as:…”

Section: Qualitative and Quantitative Microscopic Analysesmentioning

confidence: 99%

“…Thin capsules have a predominance of lymphocytes, whereas thick capsules are predominantly composed of plasma cells and macrophages. 8 Inflammatory cell count and degree of vascularization in periapical cysts have shown a strong association with increased expression of tumor necrosis factor-alpha (TNF-α), 8 indicating that inflammatory cells may have an important role in the development of these lesions.…”

Section: Introductionmentioning

confidence: 99%

Correlation between inflammatory infiltrate and epithelial lining in 214 cases of periapical cysts

et al. 2013

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The aim of this study was to evaluate the prevalence of periapical cysts, identify their clinical and microscopic features and correlate their microscopic features with the inflammatory infiltrate present in the lesion site. A total of 214 cases were collected over a 10-year period. Clinical data, including gender, age, race, symptoms and location of the lesion, were recorded. Two independent examiners with no prior knowledge of the patients' clinical data conducted the microscopic evaluations. Statistical analyses were performed using Fisher's or chi-square tests at a 5% level of significance. The results showed that periapical cysts were more prevalent in white women, with a mean age of 35 years, and in the anterosuperior region. The majority of the lesions were lined by atrophic cystic epithelium, which was associated with moderate inflammatory infiltrate in the cystic capsule (p < 0.01), with a diffuse localization pattern (p = 0.03) and absence of neutrophils (p = 0.01). Our findings suggest that periapical cysts lined by atrophic epithelium are related to the presence of moderate mononuclear inflammatory infiltrate.

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“…Jurisic, et al 13 (2008) showed a positive correlation between the concentration of TNF-α and the number of inflammatory cells in RCs. In agreement with the present study, Nonaka, et al 26 (2008) observed a lower number of immunopositive cells for VEGF in periapical lesions with few inflammatory infiltrate.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical expression of vascular endothelial growth factor and matrix metalloproteinase-9 in radicular and residual radicular cysts

Ruíz¹,

Toledo

Nonaka

et al. 2010

J. Appl. Oral Sci.

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ObjectiveThis study assessed and compared the immunoexpression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in radicular cysts (RCs) and residual radicular cysts (RRCs), relating them to the angiogenic index and the intensity of the inflammatory infiltrate. Material and MethodsTwenty RCs and 10 RRCs were evaluated by immunohistochemistry using anti-VEGF and anti-MMP-9 antibodies. The angiogenic index was determined by microvessel count (MVC) using anti-von Willebrand factor antibody. ResultsThe expression of both VEGF and MMP-9 was higher in RCs than in RRCs. RCs and RRCs presented strong epithelial expression of VEGF, irrespective of the intensity of the inflammatory infiltrate. Lesions with strong expression of MMP-9 showed significantly higher number of immunopositive cells for VEGF (p<0.05) and higher MVC (p<0.05). Lesions with dense inflammatory infiltrate exhibited significantly higher MVC (p<0.05) and higher number of immunopositive cells for VEGF (p<0.05). There was a positive correlation between both MVC (p<0.05) and the quantity of immunopositive cells for VEGF (p<0.05), with intensity of the inflammatory infiltrate. In addition, it was observed a positive correlation between the number of immunopositive cells for VEGF and MVC (p<0.05). ConclusionsVEGF and MMP-9 might play important roles in the angiogenesis in RCs and RRCs. In these lesions, the expression of these molecules and the MVC is closely related to the intensity of the inflammatory infiltrate. The expression of VEGF in the epithelial lining of RCs and RRCs might be important for the enlargement of these lesions.

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The concentration of TNF‐α correlate with number of inflammatory cells and degree of vascularization in radicular cysts

Abstract: We believe that determination of TNF-alpha in cystic fluid simultaneously with other parameters can be an additional parameter for clinical diagnosis of inflammed cysts.

Cited by 64 publications

References 21 publications

Markers of inflammation and microvascular complications in type 1 diabetes

Markers of inflammation and microvascular complications in type 1 diabetes

Correlation between inflammatory infiltrate and epithelial lining in 214 cases of periapical cysts

Immunohistochemical expression of vascular endothelial growth factor and matrix metalloproteinase-9 in radicular and residual radicular cysts

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