The Concentration of Vanadium in Pathologically Altered Human Kidneys

Wilk, Aleksandra; Wiszniewska, Barbara; Szypulska-Koziarska, Dagmara; Kaczmarek, Paulina; Romanowski, M; Różański, Jacek; Słojewski, Marcin; Ciechanowski, Kazimierz; Marchelek-Myśliwiec, Małgorzata; Kalisińska, Elżbieta

doi:10.1007/s12011-017-0986-2

Cited by 10 publications

(11 citation statements)

References 21 publications

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“…Data has been presented on the concentrations of copper in human kidneys; however, many publications do not specify whether these values relate to the cortical or medullar parts of the kidney. It is believed that the concentration of heavy metals depends on the part of the organ [35, 36]. Additionally, various biological and environmental factors affect the accumulation of trace elements.…”

Section: Introductionmentioning

confidence: 99%

“…It has been also reported that there is an association between the etiology of the disease and the concentrations of trace elements within kidneys [13, 24, 35, 36]. Our earlier studies have indicated that renal grafts accumulate less cadmium, lead, mercury, and vanadium than the kidneys, with other pathological alterations [35, 36]. No data has been found regarding the comparison of concentration of Cu between rejected renal grafts and cancerous kidneys.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Copper Concentration Between Rejected Renal Grafts and Cancerous Kidneys

Wilk

Wiszniewska

Rzuchowska

et al. 2019

Biol Trace Elem Res

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In the body, disorders in the composition and concentration of trace elements, including copper, can lead to the development of various alterations that may result in incorrect functioning of the kidneys. Data on the concentrations of copper in human kidneys are discussed; however, little is known about the concentration of trace elements within rejected renal grafts and kidneys with tumor lesions. The aim of our study was to compare the copper concentration between cancerous kidneys and rejected renal grafts with the division on renal cortex and renal medulla. Material consisted of kidneys from patients hospitalized at the Department of Urology and General Surgery and Transplantation of the Independent Public Clinical Hospital No. 2 at the Pomeranian Medical University in Szczecin, north-western Poland. The study material consisted of kidneys with tumor lesions ( n = 33), and renal grafts ( n = 10), obtained from patients belongs to the north-western areas of Poland. The examination was performed using ICP-AES method. Regarding the pathological kidneys, excluding grafts, the concentration of Cu in the renal cortex was 52% higher than in medullary region and the difference between the compared concentrations was statistically confirmed ( p < 0.05). Taking into account renal grafts, the concentration of Cu in the medulla was slightly lower than in the cortex (less than 3%). In summary, copper in rejected and cancerous kidneys tends to accumulate in higher amount in the renal cortex than medulla, what can be explained by the fact that renal corpuscles, where the first phase of filtration is performed, are located only in the cortical region of the kidney. Furthermore, renal grafts accumulate significantly less copper than kidneys with neoplastic changes, what could have been caused by immunosuppressive medicines used by the graft recipients. The lower copper concentration in renal grafts could be a consequence of the altered immune system, including inflammatory process or/and non-immune mechanisms. Additionally, cancerous and non-cancerous kidneys exhibit different perfusion rate in renal glomeruli, what can finally lead to disparity in chemical elements concentration, including copper.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of Copper Concentration Between Rejected Renal Grafts and Cancerous Kidneys

Wilk

Wiszniewska

Rzuchowska

et al. 2019

Biol Trace Elem Res

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“…Our previous study indicated that cadmium, lead, and mercury concentrations are statistically lower in renal grafts than in cancerous kidneys [32]. Moreover, we documented decreased levels of vanadium and copper in renal grafts [33,35]. This may have been caused by the immunosuppressive drugs used by the transplant recipients.…”

Section: Introductionmentioning

confidence: 56%

Serum Selenium, Iron, Zinc, and Copper Concentrations in Renal Transplant Recipients Treated with Mycophenolate Mofetil

Wilk

Szypulska-Koziarska

Marchelek-Myśliwiec

et al. 2020

Biol Trace Elem Res

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There are data available in the literature on bioelement concentrations in the serum of various groups of patients; however, very little is known about the serum concentration of selenium (Se), iron (Fe), zinc (Zn), and copper (Cu) in renal transplant patients treated with immunosuppressive drugs, including mycophenolate mofetil (MMF). Monitoring of serum bioelement concentrations in renal transplant recipients is of profound importance, as the proper bioelement levels seem to prolong the normal function of the transplanted organ. Thus, the aim of this current study was to examine and carry out comparative analysis involving serum concentrations of Se, Fe, Cu, and Zn of renal transplant recipients treated with MMF and without MMF. The material consisted of blood samples from 115 patients of the the city of Szczecin in the northwestern Poland. Serum Se, Fe, Cu, and Zn levels were quantified by inductively coupled mass spectroscopy (ICP-MS). Taking into account all patients, MMF increases Cu level. Cu and Fe concentrations were significantly higher in women treated with MMF; in group of younger patients treated with MMF, Se level was significantly lower comparing with those whose regimen did not include MMF. Additionally, MMF in combination with prednisone increased Se concentration in blood of transplant recipients. Our study highlights that trace elements should be monitored to allow for an early detection of trace elements deficits, which can easily be corrected for by an adjusted diet or supplemental intake.

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“…There was also a significant upregulation of ATPase gene activity in the LL and DD groups. ATPase is generated in the mitochondria and participates in oxidative phosphorylation in order to produce ATP [65, 66]. It is well known that ATP decomposition releases energy to promote cell growth, cell division and other vital movements [67].…”

Section: Discussionmentioning

confidence: 99%

The transcriptome sequencing and functional analysis of eyestalk ganglions in Chinese mitten crab (Eriocheir sinensis) treated with different photoperiods

Pang

Zhang

et al. 2019

PLoS ONE

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Photoperiod plays an important role in individual growth, development, and metabolism in crustaceans. The growth and reproduction of crabs are closely related to the photoperiod. However, as of yet, there are still no transcriptomic reports of eyestalk ganglions treated under different photoperiods in the Chinese mitten crab (Eriocheir sinensis), which is a benthonic crab with high commercial value in Asia. In this study, we collected the eyestalk ganglions of crabs that were reared under different photoperiods, including a control group (L: D = 12 h: 12 h, named CC), a constant light group (L: D = 24 h: 0 h, named LL) and a constant darkness group (L: D = 0 h: 24 h, named DD). RNA sequencing was performed on these tissues in order to examine the effects of different photoperiods. The total numbers of clean reads from the CC, LL and DD groups were 48,772,584 bp, 53,943,281 bp and 53,815,178 bp, respectively. After de novo assembly, 161,380 unigenes were obtained and were matched with different databases. The DEGs were significantly enriched in phototransduction and energy metabolism pathways. Results from RT-qPCR showed that TRP channel protein (TRP) in the phototransduction pathway had a significantly higher level of expression in LL and DD groups than in the CC group. We found that the downregulation of the pyruvate dehydrogenase complex (PDC) gene and the upregulation phosphoenolpyruvate carboxykinase (PPC) gene were involved in energy metabolism processes in LL or DD. In addition, we also found that the upregulation of the expression level of the genes Gαq, pyruvate kinase (PK), NADH peroxidase (NADH) and ATPase is involved in phototransduction and energy metabolism. These results may shed some light on the molecular mechanism underlying the effect of photoperiod in physiological activity of E. sinensis.

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The Concentration of Vanadium in Pathologically Altered Human Kidneys

Cited by 10 publications

References 21 publications

Comparison of Copper Concentration Between Rejected Renal Grafts and Cancerous Kidneys

Comparison of Copper Concentration Between Rejected Renal Grafts and Cancerous Kidneys

Serum Selenium, Iron, Zinc, and Copper Concentrations in Renal Transplant Recipients Treated with Mycophenolate Mofetil

The transcriptome sequencing and functional analysis of eyestalk ganglions in Chinese mitten crab (Eriocheir sinensis) treated with different photoperiods

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