The concentrations of soluble HLA-G protein are elevated during mid-gestation and decreased in pre-eclampsia

Darmochwał-Kolarz, Dorota; Kolarz, Bogdan; Roliński, Jacek; Leszczyńska‐Gorzelak, Bożena; Oleszczuk, Jan

doi:10.5603/fhc.2012.0023

Cited by 33 publications

(17 citation statements)

References 40 publications

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“…Defective HLA-G expression has been associated with PE (82). HLA-G levels in plasma from women who subsequently develop PE are lower than control patients (83, 84). MSC have been shown to secrete and express HLA-G (73, 74).…”

Section: Molecular Mechanisms Of Msc Immunosuppressive Effectmentioning

confidence: 81%

Innate Immune System and Preeclampsia

et al. 2014

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Normal pregnancy is considered as a Th2 type immunological state that favors an immune-tolerance environment in order to prevent fetal rejection. Preeclampsia (PE) has been classically described as a Th1/Th2 imbalance; however, the Th1/Th2 paradigm has proven insufficient to fully explain the functional and molecular changes observed during normal/pathological pregnancies. Recent studies have expanded the Th1/Th2 into a Th1/Th2/Th17 and regulatory T-cells paradigm and where dendritic cells could have a crucial role. Recently, some evidence has emerged supporting the idea that mesenchymal stem cells might be part of the feto-maternal tolerance environment. This review will discuss the involvement of the innate immune system in the establishment of a physiological environment that favors pregnancy and possible alterations related to the development of PE.

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Section: Molecular Mechanisms Of Msc Immunosuppressive Effectmentioning

confidence: 81%

Innate Immune System and Preeclampsia

et al. 2014

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“…The target of miRNA‐152 and 19a is HLA‐G, which is expressed by trophoblasts, the major physiological function of which is to protect the foetus from cytotoxicity of NK cells. HLA‐G plays an important role in immune tolerance at the feto‐maternal interface . Studies have shown that the expression of HLA‐G in the placenta in PE was significantly lower than in normal pregnancy and the downregulation of HLA‐G may result in the rejection of the foetus, poor invasion by trophoblasts and insufficient uterine artery remodelling.…”

Section: Innate Immunitymentioning

confidence: 99%

The role of immunity in the pathogenesis and development of pre‐eclampsia

2019

Scand J Immunol

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Pre-eclampsia (PE) is a leading cause of maternal and perinatal morbidity and mortality; however, the aetiology of PE still remains unclear. It has been widely accepted that the disease results from insufficient spiral artery remodelling, leading to placental ischaemia and the release of a variety of factors. In recent decades, a large number of studies have observed an abnormal immune response in preeclamptic women and studies of both patients and animal models have shown alterations in the function or the number of immune agents. Thus, researchers believe that alterations in the immune system may contribute to the genesis and pathophysiology of PE. Therefore, identifying the role of the immune system can not only shed light on the nature of PE but also contribute to the development of diagnostic and therapeutic methods for PE. This review focuses on the current knowledge of the immune system including both innate and adaptive immunity and sheds light on their role in PE. Additionally, advances in potential therapeutic measures are discussed.

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“…First, a direct association between reduced HLA-G expression in term placentas and preeclampsia has been demonstrated with in situ hybridization, immunohistochemistry on frozen sections, and with a ribonuclease protection assay ( 65 – 67 ). Second, circulating sHLA-G levels are decreased in preeclampsia, and in some cases this is observed as an early event in pregnancy in women who subsequently develop preeclampsia compared with women with uncomplicated pregnancy ( 62 , 64 , 68 – 70 ). Third, HLA-G polymorphisms have been associated with sHLA-G levels in peripheral blood from blood donors and with HLA-G protein expression in the placenta during pregnancy ( 71 , 72 ), and fourth, HLA-G polymorphisms, some of which are associated with circulating levels, are further associated with increased risk of preeclampsia in some studies ( 73 – 76 ) but not in all ( 77 – 80 ).…”

Section: Hla-g In Pregnancy and Preeclampsiamentioning

confidence: 99%

HLA Class Ib Molecules and Immune Cells in Pregnancy and Preeclampsia

Djurisic

Hviid

2014

Front. Immunol.

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Despite decades of research, the highly prevalent pregnancy complication preeclampsia, “the disease of theories,” has remained an enigma. Indeed, the etiology of preeclampsia is largely unknown. A compiling amount of studies indicates that the pathological basis involves a complex array of genetic predisposition and immunological maladaptation, and that a contribution from the mother, the father, and the fetus is likely to be important. The Human Leukocyte Antigen (HLA)-G is an increasing focus of research in relation to preeclampsia. The HLA-G molecule is primarily expressed by the extravillous trophoblast cells lining the placenta together with the two other HLA class Ib molecules, HLA-E and HLA-F. Soluble isoforms of HLA-G have been detected in the early endometrium, the matured cumulus–oocyte complex, maternal blood of pregnant women, in umbilical cord blood, and lately, in seminal plasma. HLA-G is believed to be involved in modulating immune responses in the context of vascular remodeling during pregnancy as well as in dampening potential harmful immune attacks raised against the semi-allogeneic fetus. In addition, HLA-G genetic variants are associated with both membrane-bound and soluble forms of HLA-G, and, in some studies, with preeclampsia. In this review, a genetic contribution from the mother, the father, and the fetus, together with the presence and function of various immune cells of relevance in pregnancy are reviewed in relation to HLA-G and preeclampsia.

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The concentrations of soluble HLA-G protein are elevated during mid-gestation and decreased in pre-eclampsia

Cited by 33 publications

References 40 publications

Innate Immune System and Preeclampsia

Innate Immune System and Preeclampsia

The role of immunity in the pathogenesis and development of pre‐eclampsia

HLA Class Ib Molecules and Immune Cells in Pregnancy and Preeclampsia

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