Abstract. The article covers safety and environmental issues, as well as the sustainable interaction between man and nature in the context of present-day cities. An important task, according to the authors, is the study of scientific approaches and practical achievements in this field, and then the detection of the most urgent critical issues. The coauthors provide an overview of numerous research projects on the treatment of nature, the anthropogenic load, the biosphere as a geological body, the noosphere, and ratios characterizing the condition of the biosphere. The coauthors believe that ecological management, aimed to reverse the treatment of nature, must be integrative. New legislation, effective control of its execution, new disciplines to be introduced at the level of secondary, vocational, and higher education, development of ecological schools of thought and advanced green standards and materials applicable to any construction operations may comprise an effective solution. The authors offer their vision of the challenges and outline the primary steps, including immediate implementation of urban planning solutions to be developed in accordance with the biosphere compatibility principles, with calculations of humanitarian balances of the bio-technosphere. The coauthors also consider the innovative approaches to the use of eco-friendly materials in construction projects.