THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Nuclear hormone receptors

Alexander, Stephen P.H.; Cidlowski, John A.; Kelly, Eamonn; Mathie, Alistair; Peters, John A.; Veale, Emma L.; Armstrong, Jane F.; Faccenda, Elena; Harding, Simon D; Pawson, Adam J.; Southan, Christopher; Davies, Jamie A.; Coons, Laurel A.; Fuller, Peter J.; Korach, Kenneth S.; Young, Morag J.

doi:10.1111/bph.15540

Cited by 120 publications

(123 citation statements)

References 35 publications

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“…Key protein targets and ligands in this article are hyperlinked to corresponding entries in http://www.guidetopharmacology.org, and are permanently archived in the Concise Guide to PHARMACOLOGY 2021/22 (Alexander, Christopoulos, et al, 2021; Alexander, Cidlowski, et al, 2021; Alexander, Fabbro, et al, 2021a, 2021b; Alexander, Kelly, et al, 2021; Alexander, Mathie, et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Inflammation, ageing and diseases of the lung: Potential therapeutic strategies from shared biological pathways

Faniyi

Hughes

Scott

et al. 2022

British J Pharmacology

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Lung diseases disproportionately affect elderly individuals. The lungs form a unique environment: a highly elastic organ with gaseous exchange requiring the closest proximity of inhaled air containing harmful agents and the circulating blood. The lungs are highly susceptible to senescence, with age and ‘inflammageing’ creating a pro‐inflammatory environment with a reduced capacity to deal with challenges. While lung diseases may have disparate causes, the burden of ageing and inflammation provides a common process that can exacerbate seemingly unrelated pathologies. However, these shared pathways may also provide a common route to treatment, with increased interest in drugs that target ageing processes across respiratory diseases. In this review, we will examine the evidence for the increased burden of lung disease in older adults, the structural and functional changes seen with advancing age and assess what our expanding knowledge of inflammation and ageing pathways could mean for the treatment of lung disease. LINKED ARTICLES This article is part of a themed issue on Inflammation, Repair and Ageing. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.9/issuetoc

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Section: Discussionmentioning

confidence: 99%

Inflammation, ageing and diseases of the lung: Potential therapeutic strategies from shared biological pathways

Faniyi

Hughes

Scott

et al. 2022

British J Pharmacology

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“…Key protein targets and ligands in this article are hyperlinked to corresponding entries in http://www.guidetopharmacology.org , the common portal for data from the IUPHAR/BPS Guide to PHARMACOLOGY, 15 and are permanently archived in the Concise Guide to PHARMACOLOGY 2021/22. 16 , 17 , 18 , 19 …”

Section: Methodsmentioning

confidence: 99%

Untargeted metabolomics identifies the potential role of monocarboxylate transporter 6 (MCT6/SLC16A5) in lipid and amino acid metabolism pathways

Ren

Jones

Morris

2022

Pharmacology Res & Perspec

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Monocarboxylate transporter 6 (MCT6; SLC16A5 ) is an orphan transporter protein with expression in multiple tissues. The endogenous function of MCT6 related to human health and disease remains unknown. Our previous transcriptomic and proteomic analyses in Mct6 knockout (KO) mice suggested that MCT6 may play a role in lipid and glucose homeostasis, but additional evidence is required. Thus, the objective of this study was to further explore the impact of MCT6 on metabolic function using untargeted metabolomic analysis in Mct6 KO mice. The plasma from male and female mice and livers from male mice were submitted for global metabolomics analysis to assess the relative changes in endogenous small molecules across the liver and systemic circulation associated with absence of Mct6. More than 782 compounds were detected with 101 and 51 metabolites significantly changed in plasma of male and female mice, respectively, and 100 metabolites significantly changed in the livers of male mice ( p < .05). Significant perturbations in lipid metabolism were annotated in the plasma and liver metabolome, with additional alterations in the amino acid metabolism pathway in plasma samples from male and female mice. Elevated lipid diacylglycerol and altered fatty acid metabolite concentrations were found in liver and plasma samples of male Mct6 KO mice. Significant reduction of N‐terminal acetylated amino acids was found in plasma samples of male and female Mct6 KO mice. In summary, the present study confirmed the significant role of MCT6 in lipid and amino acid homeostasis, suggesting its contribution in metabolic diseases.

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“…org, the common portal for data from the IUPHAR/BPS guide to PHARMACOLOGY, 260 and are permanently archived in the Concise Guide to PHARMACOLOGY 2019/2020. 261,262…”

Section: Nomen CL Ature Of Targ E Ts and Li G Andsmentioning

confidence: 99%

“…Key protein targets and ligands in this article are hyperlinked to corresponding entries in http://www.guidetopharmacology.org, the common portal for data from the IUPHAR/BPS guide to PHARMACOLOGY, 260 and are permanently archived in the Concise Guide to PHARMACOLOGY 2019/2020 261,262 …”

Section: Nomenclature Of Targets and Ligandsmentioning

confidence: 99%

New insights into the role of melatonin in diabetic cardiomyopathy

Huang

Luo

Zhong

et al. 2022

Pharmacology Res & Perspec

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Thirty years ago, the prevalence of diabetic patients was only onefourth the current prevalence. In fact, the current number of diabetic patients has soared to 1 diabetic patient in every 11 people globally. 1 Moreover, diabetes has become the ninth leading cause of death worldwide. According to statistics from the World Health Organization, as of 2000, the number of diabetes patients worldwide had exceeded 170 million, and it is still increasing at an extremely fast rate. It is predicted that the number of diabetic-related deaths will double between 2000 and 2030. 2 Among diabetic patients, type 2 diabetes mellitus (T2DM) is most common, accounting for approximately 90% of adult patients with diabetes. Unlike type 1 diabetes mellitus (T1DM), which is an autoimmune disease, the

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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Nuclear hormone receptors

Cited by 120 publications

References 35 publications

Inflammation, ageing and diseases of the lung: Potential therapeutic strategies from shared biological pathways

Inflammation, ageing and diseases of the lung: Potential therapeutic strategies from shared biological pathways

Untargeted metabolomics identifies the potential role of monocarboxylate transporter 6 (MCT6/SLC16A5) in lipid and amino acid metabolism pathways

New insights into the role of melatonin in diabetic cardiomyopathy

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