The concurrence of diabetes mellitus and gallstone disease

Терещенко, И. В.; Kamenskikh, Ya A; Kayushev, P E

doi:10.17116/terarkh20158710105-109

Cited by 2 publications

(2 citation statements)

References 52 publications

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“…Previous studies have designed various models for predicting the risk of GBS development in T2DM [ 15 , 16 ], although these are used infrequently due to wide variations in individual differences in populations. Our study is the first to use a nomogram for predicting GBS risk in Chinese patients with T2DM.…”

Section: Discussionmentioning

confidence: 99%

Nomogram for predicting gallbladder stone in patients with type 2 diabetes mellitus: a retrospective study in the Chinese population

Wang

2023

Annals of Medicine

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Objective The purpose of this study is to explore the risk factors of gallbladder stone (GBS) in patients with type 2 diabetes mellitus (T2DM) and also develop a simple-to-use nomogram for GBS in patients with T2DM. Methods This study retrospectively analyzed 2243 patients with T2DM hospitalized in Peking University International Hospital from January 2017 to August 2022. According to the results of colour Doppler ultrasonic examinations, the patients were divided into two groups. Results (1) Compared with the non-GBS group, the GBS group was older ( p < 0.05), and the diabetes duration in the GBS group was longer ( p < 0.05). The proportion of overweight and obese people in the GBS group was significantly higher than that in the non-GBS group ( p < 0.05, respectively). The proportion of patients with diabetic nephropathy (DN) and diabetic peripheral neuropathy (DPN) was higher in the GBS group ( p < 0.05, respectively). (2) Logistic regression showed that age, body mass index (BMI), diabetes duration, total cholesterol (TC), triglycerides (TG), alanine aminotransferase (ALT), DN, and DPN were independent risk factors for GBS ( p < 0.05, respectively). (3) The area under the curve (AUC) of the nomogram for GBS was 0.704 (95% CI 0.656, 0.748), with a specificity of 90.34%, a sensitivity of 55.38%, and an accuracy of 86.83%. Conclusion The nomogram is accurate to a certain degree and provides a clinical basis for predicting the incidence of GBS in patients with T2DM, which has a certain predictive value.

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Section: Discussionmentioning

confidence: 99%

Nomogram for predicting gallbladder stone in patients with type 2 diabetes mellitus: a retrospective study in the Chinese population

Wang

2023

Annals of Medicine

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“…GBS is closely related to DM, especially to T2DM. The proportion of patients with T2DM who suffer from GBS is more than 30%; while the incidence of GBS in patients without DM is only 10%, the incidence of GBS with DM is three times that without DM [12,13]. Therefore, the study of the relationship between GBS and T2DM has important clinical significance for the diagnosis and treatment of patients with both GBS and T2DM.…”

Section: Discussionmentioning

confidence: 99%

The Correlation between Islet β Cell Secretion Function and Gallbladder Stone Disease: A Retrospective Study Based on Chinese Patients with Newly Diagnosed Type 2 Diabetes Mellitus

Wu,

Wang,

et al. 2023

Biomedicines

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Background: This study aimed to analyze the correlation between islet β cell function and gallbladder stone (GBS) in newly diagnosed type 2 diabetes mellitus (T2DM) patients. Methods: A total of 438 newly diagnosed T2DM patients in Peking University International Hospital from January 2017 to August 2022 were retrospectively analyzed and divided into a non-GBS group and a GBS group. Results: (1) The homeostasis model assessment of the insulin resistance (HOMA-IR) of the GBS group was higher than that of the non-GBS group (p < 0.05), while the homeostasis model assessment of β cell (HOMA-β), disposition index (DI0), and Matsuda index of the GBS group were lower than those of the non-GBS group (all p < 0.05). (2) For male patients, HOMA-IR is an independent risk factor for GBS (OR = 2.00, 95% CI:1.03, 3.88, p < 0.05), and the Matsuda index value is a protective factor for GBS (OR = 0.76, 95% CI:0.60, 0.96, p < 0.05). For female patients, HOMA-IR is an independent risk factor for GBS (OR = 2.80, 95% CI:1.03, 7.58, p < 0.05) and the Matsuda index value is a protective factor for GBS (OR = 0.59, 95% CI:0.39, 0.90, p < 0.05). (3) For male patients, the area under curve (AUC) for predicting GBS was 0.77 (95% CI 0.67, 0.87), with a specificity of 75.26%, a sensitivity of 80.00%, and an accuracy of 75.64%. For female patients, the AUC for predicting GBS was 0.77 (95% CI 0.63, 0.88), with a specificity of 79.63%, a sensitivity of 71.43%, and an accuracy of 78.69%. Conclusions: Insulin resistance may be an independent risk factor for the incidence of GBS in patients with newly diagnosed T2DM, both male or female, which provides a new clinical basis and research direction for the prevention and treatment of GBS in patients with T2DM. This study has established a predictive model of GBS in T2DM and found it to be accurate, thus representing an effective tool for the early prediction of GBS in patients with T2DM.

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The concurrence of diabetes mellitus and gallstone disease

Cited by 2 publications

References 52 publications

Nomogram for predicting gallbladder stone in patients with type 2 diabetes mellitus: a retrospective study in the Chinese population

Nomogram for predicting gallbladder stone in patients with type 2 diabetes mellitus: a retrospective study in the Chinese population

The Correlation between Islet β Cell Secretion Function and Gallbladder Stone Disease: A Retrospective Study Based on Chinese Patients with Newly Diagnosed Type 2 Diabetes Mellitus

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