The Conjugated Auxin Indole-3-Acetic Acid–Aspartic Acid Promotes Plant Disease Development

González-Lamothe, Rocío; Oirdi, Mohamed El; Brisson, Normand; Bouarab, Kamal

doi:10.1105/tpc.111.095190

Cited by 125 publications

(107 citation statements)

References 84 publications

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“…The overexpression of three different IAA-amido synthases in rice decreased free IAA levels and enhanced resistance to both fungal and bacterial pathogens (Ding et al, 2008;Domingo et al, 2009;Fu et al, 2011b). In contrast with the findings in rice, recent studies in Arabidopsis suggest that the GH3-catalyzed formation of the IAA-Asp conjugate is involved in the promotion of disease development (González-Lamothe et al, 2012).…”

Section: Introductioncontrasting

confidence: 39%

“…The amino acid conjugated can determine the fate of the bound auxin as some conjugates are oxidized (Tsurumi and Wada, 1986;Plüss et al, 1989;Östin et al, 1998), whereas others can release free IAA through hydrolysis (reviewed in Ludwig-Müller, 2011). There is also evidence that some of the conjugates themselves have biological activity in plant development and disease response (Cohen and Baldi, 1983;Magnus et al, 1992;Oetiker and Aeschbacher, 1997;Staswick, 2009;González-Lamothe et al, 2012). It should be kept in mind that the metabolism of IAA conjugates as well as their biological activity may differ from one plant species to another.…”

Section: Discussionmentioning

confidence: 99%

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Crystal Structure of an Indole-3-Acetic Acid Amido Synthetase from Grapevine Involved in Auxin Homeostasis

et al. 2012

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Auxins are important for plant growth and development, including the control of fruit ripening. Conjugation to amino acids by indole-3-acetic acid (IAA)-amido synthetases is an important part of auxin homeostasis. The structure of the auxinconjugating Gretchen Hagen3-1 (GH3-1) enzyme from grapevine (Vitis vinifera), in complex with an inhibitor (adenosine-59-[2-(1H-indol-3-yl)ethyl]phosphate), is presented. Comparison with a previously published benzoate-conjugating enzyme from Arabidopsis thaliana indicates that grapevine GH3-1 has a highly similar domain structure and also undergoes a large conformational change during catalysis. Mutational analyses and structural comparisons with other proteins have identified residues likely to be involved in acyl group, amino acid, and ATP substrate binding. Vv GH3-1 is a monomer in solution and requires magnesium ions solely for the adenlyation reaction. Modeling of IAA and two synthetic auxins, benzothiazole-2-oxyacetic acid (BTOA) and 1-naphthaleneacetic acid (NAA), into the active site indicates that NAA and BTOA are likely to be poor substrates for this enzyme, confirming previous enzyme kinetic studies. This suggests a reason for the increased effectiveness of NAA and BTOA as auxins in planta and provides a tool for designing new and effective auxins.

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Section: Introductioncontrasting

confidence: 39%

Section: Discussionmentioning

confidence: 99%

Crystal Structure of an Indole-3-Acetic Acid Amido Synthetase from Grapevine Involved in Auxin Homeostasis

et al. 2012

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“…Conversely, auxin signaling promotes resistance to the necrotrophic fungal pathogens B. cinerea, Plectosphaerella cucumerina, and Alternaria brassicicola (Llorente et al, 2008). However, the effect of different auxins on different B. cinerea strains seems to be different (González-Lamothe et al, 2012). Suppression of the SA pathway by auxin during the Arabidopsis-P. syringae interaction has been reported (Wang et al, 2007;Iglesias et al, 2011).…”

Section: Effector-mediated Manipulation Of the Auxin Pathwaymentioning

confidence: 99%

Intervention of Phytohormone Pathways by Pathogen Effectors

2014

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“…In Momordica the response to Cuscuta was different. Gonzalez-Lamothe et al (2012) proposed the model that IAA-Asp, by way of GH3-2, promotes plant disease.…”

Section: Plant Hormonal Changes In Momordicamentioning

confidence: 99%

Morphological and plant hormonal changes during parasitization by Cuscuta japonica on Momordica charantia

Furuhashi

Kojima

Sakakibara

et al. 2013

Journal of Plant Interactions

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The holostemparasitic plant Cuscuta parasitizes various plants and sucks nutrients from the host stem. We used Cuscuta japonica as the parasite and Momordica charantia as the host plant, and described their interaction. The parasitized Momordica stems started swelling as a hypertrophic response within 3 days after parasitization. Concurrently, the Cuscuta stem grew rapidly and developed bigger scale leaves than usual. Parasitized Momordica stems reduced photosynthetic activity. Histological observation revealed no programmed cell death but an increased number of vascular bundles in the Momordica stem, especially near the Cuscuta hyphae. The defensive response of Momordica mainly involved the SA pathway. Drastic increase of tZ-and DZ-type cytokinins in Momordica stems would play an important role for hypertrophy. Cuscuta had higher cZ endogenously and our results imply that each subtype of CK might play different roles during parasitization process. Comprehensive plant hormone analysis provides new insights into plant interaction studies.

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The Conjugated Auxin Indole-3-Acetic Acid–Aspartic Acid Promotes Plant Disease Development

Cited by 125 publications

References 84 publications

Crystal Structure of an Indole-3-Acetic Acid Amido Synthetase from Grapevine Involved in Auxin Homeostasis

Crystal Structure of an Indole-3-Acetic Acid Amido Synthetase from Grapevine Involved in Auxin Homeostasis

Intervention of Phytohormone Pathways by Pathogen Effectors

Morphological and plant hormonal changes during parasitization by Cuscuta japonica on Momordica charantia

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