The Conservative Treatment of Arteriosclerotic Peripheral Vascular Diseases

The acute effects of different levels of intermittent negative pressure on peripheral circulation in patients with peripheral artery disease

“…This may be explained by the increased blood flow during INP leading to increased shear stress between the blood and the endothelium of the arterial wall, and thereby inducing flow‐mediated vasodilatation (Joannides et al ). Hence, flow‐mediated vasodilatation may be one physiological explanation for the potential clinical benefits of INP treatment for patients with PAD that have been presented in a number of studies (Herrmann and Reid, (); Sundby et al ; Himmelstrup et al ; Smyth ; Mehlsen et al ).…”

Acute Effects of Intermittent Pneumatic Compression on Popliteal Artery Blood Flow

“…The beneficial effect of intermittent pneumatic compression was first described in 2 reports in 1934 22,23 ; however, favorable clinical results were not attributed to increased tissue perfusion because blood flow could not be measured. Using xenon 133 clearance rates, Gaskell and Parrott 24 demonstrated that pneumatic foot and ankle compression increased the blood flow 80% in the limbs of sitting patients with peripheral arterial disease.…”

Nonoperative Active Management of Critical Limb Ischemia: Initial Experience Using a Sequential Compression Biomechanical Device for Limb Salvage

“…This finding is in keeping with previous reports that documented improvement and partial to complete relief of rest pain. 14,15,35,41 We were unable to demonstrate a significant improvement in mean PBFV, which increased by 7% (p 5 .531). Labropoulos and colleagues demonstrated significant improvements in popliteal artery blood flow in the pericompression period.…”

“…Treatment was spread throughout the day at two intervals. 9,11,15 The device was applied to the symptomatic leg(s) while the patient was sitting upright in a chair, and this could be easily done in the patient's home ( Figure 1). …”