The construct validity of the ischemic score of Hachinski for the detection of dementias

Db, Larson; Js, Lyons; Jc, Bareta; Bj, Burns; Dg, Blazer; Id, Goldstrom

doi:10.1176/jnp.1.2.181

Cited by 13 publications

(2 citation statements)

References 13 publications

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“…All participants had also undergone a series of standardized neuropsychological evaluations, including tests that measured cognitive functioning in the domains of memory, executive functioning, attention, and language. The basic set of psychological tests included the Mini-Mental State Examination (MMSE; Folstein et al, 1975), the Montreal Cognitive Assessment (MoCA, Beijing version;Lu et al, 2011), the Clinical Dementia Rating (CDR) Scale (Morris, 1993), the Global Deterioration Scale (GDS; Reisberg et al, 1982), Chinese Huashan version of auditory verbal learning test [AVLT, including AVLT-immediate recall, AVLT-delayed recall (AVLT-DR), and AVLT-recognition; Xu et al, 2020], activities of daily living assessment (Barberger-Gateau et al, 1992), the Hachinski Ischemic Scale (HIS; Larson et al, 1989), and the Hamilton Depression Rating Scale (HAM-D; Worboys, 2013).…”

Section: Human Subjects and Neuropsychological Testingmentioning

confidence: 99%

Microstructural and Cerebral Blood Flow Abnormalities in Subjective Cognitive Decline Plus: Diffusional Kurtosis Imaging and Three-Dimensional Arterial Spin Labeling Study

Yang

Cao

et al. 2021

Front. Aging Neurosci.

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Objective: To explore microstructural and cerebral blood flow (CBF) abnormalities in individuals with subjective cognitive decline plus (SCD plus) using diffusional kurtosis imaging (DKI) and three-dimensional (3D) arterial spin labeling (ASL).Methods: Twenty-seven patients with SCD plus, 31 patients with amnestic mild cognitive impairment (aMCI), and 33 elderly controls (ECs) were recruited and underwent DKI and 3D ASL using a GE 3.0-T MRI. Mean kurtosis (MK), fractional anisotropy (FA), mean diffusivity (MD), and CBF values were acquired from 24 regions of interest (ROIs) in the brain, including the bilateral hippocampal (Hip) subregions (head, body, and tail), posterior cingulate cortex (PCC), precuneus, dorsal thalamus subregions (anterior nucleus, ventrolateral nucleus, and medial nucleus), lenticular nucleus, caput nuclei caudati, white matter (WM) of the frontal lobe, and WM of the occipital lobe. Pearson's correlation analysis was performed to assess the relationships among the DKI-derived parameters, CBF values, and key neuropsychological tests for SCD plus.Results: Compared with ECs, participants with SCD plus showed a significant decline in MK and CBF values, mainly in the Hip head and PCC, and participants with aMCI exhibited more significant abnormalities in the MK and CBF values than individuals with ECs and SCD plus in multiple regions. Combined MK values showed better discrimination between patients with SCD plus and ECs than that obtained using CBF levels, with areas under the receiver operating characteristic (ROC) curve (AUC) of 0.874 and 0.837, respectively. Similarly, the AUC in discriminating SCD plus from aMCI patients obtained using combined MK values was 0.823, which was also higher than the combined AUC of 0.779 obtained using CBF values. Moreover, MK levels in the left Hip (h) and left PCC positively correlated with the auditory verbal learning test-delayed recall (AVLT-DR) score in participants with SCD plus. By contrast, only the CBF value in the left Hip head positively correlated with the AVLT-DR score.Conclusions: Our results provide new evidence of microstructural and CBF changes in patients with SCD plus. MK may be used as an early potential neuroimaging biomarker and may be a more sensitive DKI parameter than CBF at the very early stage of Alzheimer's disease (AD).

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Section: Human Subjects and Neuropsychological Testingmentioning

confidence: 99%

Microstructural and Cerebral Blood Flow Abnormalities in Subjective Cognitive Decline Plus: Diffusional Kurtosis Imaging and Three-Dimensional Arterial Spin Labeling Study

Yang

Cao

et al. 2021

Front. Aging Neurosci.

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“…Enrollment methodology has been previously described (12, 25). Exclusion criteria included MMSE at enrollment <16, Hachinski score >4 (26), clinical or imaging evidence of stroke, and participants with active cold or allergies, as these may be influence olfactory function. The comparison group consisted of non-demented participants meeting the following criteria: >65 years of age, normal performance on activities of daily living and Clinical Dementia Rating scale score of 0, as assessed by a surrogate.…”

Section: Methodsmentioning

confidence: 99%

Odorant Item Specific Olfactory Identification Deficit May Differentiate Alzheimer Disease From Aging

Woodward¹,

Hafeez²,

Qi³

et al. 2018

The American Journal of Geriatric Psychiatry

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Nonoverlapping UPSIT items were identified that were individually associated with age and disease. Despite a modest predictive value of the AD-specific items for conversion to AD, the AD-specific items may be useful in enriching samples to better identify those at risk for AD. Further studies are needed with monomolecular and unilateral stimulation and orthogonal biomarker validation to further refine disease- and age-associated signals.

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Vascular dementia: dead or alive?

Rao

Howard

1998

Int. J. Geriat. Psychiatry

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The construct validity of the ischemic score of Hachinski for the detection of dementias

Cited by 13 publications

References 13 publications

Microstructural and Cerebral Blood Flow Abnormalities in Subjective Cognitive Decline Plus: Diffusional Kurtosis Imaging and Three-Dimensional Arterial Spin Labeling Study

Microstructural and Cerebral Blood Flow Abnormalities in Subjective Cognitive Decline Plus: Diffusional Kurtosis Imaging and Three-Dimensional Arterial Spin Labeling Study

Odorant Item Specific Olfactory Identification Deficit May Differentiate Alzheimer Disease From Aging

Vascular dementia: dead or alive?

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