The Construction of Biomimetic Cementum Through a Combination of Bioskiving and Fluorine-Containing Biomineralization

Li, Yanshan; Hong, Yubing; Li, Chi; Liu, Chuanzi; Yu, Liping; Wang, Qinmei; Yu, Yingjie; Xu, Qiaobing; Teng, Wei

doi:10.3389/fbioe.2020.00341

Cited by 15 publications

(21 citation statements)

References 57 publications

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Section: Cementum Regeneration Using Scaffold Fabricationmentioning

confidence: 99%

“…In contrast to other mineralized tissues, cementum has a high concentration of fluoride, which is a great potential candidate as a catalysis to contribute to tissue mineralization and to accelerate cementum regeneration through mineral deposition on tooth-root surfaces [ 185 ]. Recently, Yang et al developed collagen scaffolds with fluorine-contained amorphous calcium phosphates (FACP) to promote mineralized tissue formation on tooth-root surfaces with specific micron-scaled dimensions [ 185 ]. To create similar hierarchical constructs to cementum with unique alternating collagen lamella (ACL) structures, the FACP–collagen scaffold was fabricated using the Bioskiving process, which is a newly developed method for the 3D scaffolding system using decellularized tendon tissues [ 185 ].…”

Section: Cementum Regeneration Using Scaffold Fabricationmentioning

confidence: 99%

“…Recently, Yang et al developed collagen scaffolds with fluorine-contained amorphous calcium phosphates (FACP) to promote mineralized tissue formation on tooth-root surfaces with specific micron-scaled dimensions [ 185 ]. To create similar hierarchical constructs to cementum with unique alternating collagen lamella (ACL) structures, the FACP–collagen scaffold was fabricated using the Bioskiving process, which is a newly developed method for the 3D scaffolding system using decellularized tendon tissues [ 185 ]. In particular, the technique can three-dimensionally organize the nano-/microstructures of collagen constructs through a combination of processes, such as sectioning tendon-derived (tenton-decellularized) structures and stacking sheets with alternating orientations of collagen lamellae ( Figure 8 ) [ 185 , 186 ].…”

Section: Cementum Regeneration Using Scaffold Fabricationmentioning

confidence: 99%

“…Because this study showed that biomimetic cementum structures with human PDL cells were found subcutaneously in immunodeficient mice, it was not demonstrated that the biomineralized collagen scaffold fabricated using the Bioskiving method was able to create a cementum layer on the tooth-root surface and tissue integration with the tooth dentin surface. However, the technique was able to mimic sophisticated hierarchies of human cementum with rotated-stacked angular microstructures and promoted mineralized tissue formation in physiological microenvironments [ 185 ].…”

Section: Cementum Regeneration Using Scaffold Fabricationmentioning

confidence: 99%

Section: Biomimetic Cementum Fabrication Using Collagen Lamella Constructsmentioning

confidence: 99%

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Tooth-Supporting Hard Tissue Regeneration Using Biopolymeric Material Fabrication Strategies

Kim

Park

2020

Molecules

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The mineralized tissues (alveolar bone and cementum) are the major components of periodontal tissues and play a critical role to anchor periodontal ligament (PDL) to tooth-root surfaces. The integrated multiple tissues could generate biological or physiological responses to transmitted biomechanical forces by mastication or occlusion. However, due to periodontitis or traumatic injuries, affect destruction or progressive damage of periodontal hard tissues including PDL could be affected and consequently lead to tooth loss. Conventional tissue engineering approaches have been developed to regenerate or repair periodontium but, engineered periodontal tissue formation is still challenging because there are still limitations to control spatial compartmentalization for individual tissues and provide optimal 3D constructs for tooth-supporting tissue regeneration and maturation. Here, we present the recently developed strategies to induce osteogenesis and cementogenesis by the fabrication of 3D architectures or the chemical modifications of biopolymeric materials. These techniques in tooth-supporting hard tissue engineering are highly promising to promote the periodontal regeneration and advance the interfacial tissue formation for tissue integrations of PDL fibrous connective tissue bundles (alveolar bone-to-PDL or PDL-to-cementum) for functioning restorations of the periodontal complex.

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Section: Cementum Regeneration Using Scaffold Fabricationmentioning

confidence: 99%

Section: Cementum Regeneration Using Scaffold Fabricationmentioning

confidence: 99%

Section: Cementum Regeneration Using Scaffold Fabricationmentioning

confidence: 99%

Section: Cementum Regeneration Using Scaffold Fabricationmentioning

confidence: 99%

Section: Biomimetic Cementum Fabrication Using Collagen Lamella Constructsmentioning

confidence: 99%

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Tooth-Supporting Hard Tissue Regeneration Using Biopolymeric Material Fabrication Strategies

Kim

Park

2020

Molecules

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Unraveling Nanomaterials in Biomimetic Mineralization of Dental Hard Tissue: Focusing on Advantages, Mechanisms, and Prospects

Dai,

Li,

Zhang

2024

Advanced Science

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The demineralization of dental hard tissue imposes considerable health and economic burdens worldwide, but an optimal method that can repair both the chemical composition and complex structures has not been developed. The continuous development of nanotechnology has created new opportunities for the regeneration and repair of dental hard tissue. Increasingly studies have reported that nanomaterials (NMs) can induce and regulate the biomimetic mineralization of dental hard tissue, but few studies have examined how they are involved in the different stages, let alone the relevant mechanisms of action. Besides their nanoscale dimensions and excellent designability, NMs play a corresponding role in the function of the raw materials for mineralization, mineralized microenvironment, mineralization guidance, and the function of mineralized products. This review comprehensively summarizes the advantages of NMs and examines the specific mineralization mechanisms. Design strategies to promote regeneration and repair are summarized according to the application purpose of NMs in the oral cavity, and limitations and development directions in dental hard tissue remineralization are proposed. This review can provide a theoretical basis to understand the interaction between NMs and the remineralization of dental hard tissue, thereby optimizing design strategy, rational development, and clinical application of NMs in the field of remineralization.

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Cementum is key to periodontal tissue regeneration: A review on apatite microstructures for creation of novel cementum‐based dental implants

Saito

Onuma

Yamakoshi

2023

Genesis

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Summary The cementum is the outermost layer of hard tissue covering the dentin within the root portion of the teeth. It is the only hard tissue with a specialized structure and function that forms a part of both the teeth and periodontal tissue. As such, cementum is believed to be critical for periodontal tissue regeneration. In this review, we discuss the function and histological structure of the cementum to promote crystal engineering with a biochemical approach in cementum regenerative medicine. We review the microstructure of enamel and bone while discussing the mechanism underlying apatite crystal formation to infer the morphology of cementum apatite crystals and their complex structure with collagen fibers. Finally, the limitations of the current dental implant treatments in clinical practice are explored from the perspective of periodontal tissue regeneration. We anticipate the possibility of advancing periodontal tissue regenerative medicine via cementum regeneration using a combination of material science and biochemical methods.

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The Construction of Biomimetic Cementum Through a Combination of Bioskiving and Fluorine-Containing Biomineralization

Cited by 15 publications

References 57 publications

Tooth-Supporting Hard Tissue Regeneration Using Biopolymeric Material Fabrication Strategies

Tooth-Supporting Hard Tissue Regeneration Using Biopolymeric Material Fabrication Strategies

Unraveling Nanomaterials in Biomimetic Mineralization of Dental Hard Tissue: Focusing on Advantages, Mechanisms, and Prospects

Cementum is key to periodontal tissue regeneration: A review on apatite microstructures for creation of novel cementum‐based dental implants

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