The consumption of two or more fall risk‐increasing drugs rather than polypharmacy is associated with falls

Zia, Anam; Kamaruzzaman, Shahrul Bahyah; Tan, Maw Pin

doi:10.1111/ggi.12741

Cited by 71 publications

(61 citation statements)

References 32 publications

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“…Several medications have been identified as fall-riskincreasing drugs (FRIDs) [4][5][6][7][8]. The association between an increased risk of falling and the use of psychotropic medications, such as antidepressants, antipsychotics and benzodiazepines, seems well established, as indicated by odds ratios ranging from 1.3 to 2 in a recent metanalysis [8].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of medication-related falls in 200 consecutive elderly patients with hip fractures: a cross-sectional study

et al. 2020

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Background: Hip fractures constitute a major health problem in elderly people and are often fall-related. Several factors can contribute to a fall episode leading to hip fracture, including fall-risk-increasing drugs (FRIDs), which are often used by elderly people. We aimed to investigate the prevalence of medication-related falls and to assess the role of FRIDs and potentially inappropriate medications (PIMs) in a population of elderly patients hospitalized for a hip fracture. Methods: We reviewed the patient records of 200 consecutive patients, aged ≥65 years, who were admitted for a hip fracture and evaluated whether medications were likely to have contributed to the fall episode. PIMs were identified using the Screening Tool of Older Persons' Prescriptions version 2 (STOPP) and by evaluating indications, contra-indications and interactions of the prescribed medications for each patient. Results: FRIDs were used by 175 patients (87.5%). Medications were considered a likely contributor to the fall in 82 patients (41%). These were most often psychotropic medications alone or in combination with antihypertensives and/or diuretics. The 82 patients with suspected medication-related falls used more medications, FRIDs and PIMs than the rest of the patients, and in 74 (90%) of the 82 patients, at least one medication considered to be a contributor to the fall was also a PIM. Conclusions: The prevalence of suspected medication-related falls was 41%. It seems likely that a medication review could have reduced, though not eliminated, the risk of falling in this group of patients.

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Section: Introductionmentioning

confidence: 99%

Prevalence of medication-related falls in 200 consecutive elderly patients with hip fractures: a cross-sectional study

et al. 2020

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“…laxatives, antiepileptics, non-steroidal anti-inflammatory drugs, analgesics, or proton pumps inhibitors) (Seppala et al, 2018b). There is clear evidence that the combination of two or more risk drugs increases the risk of fall (Zia et al, 2017). J Appl Biomed DOI: 10.32725/jab.2019.001…”

Section: Introductionmentioning

confidence: 99%

Pharmacotherapy as major risk factor of falls - analysis of 12 months experience in hospitals in South Bohemia

Malý¹,

Doseděl²,

Vosátka³

et al. 2019

J Appl Biomed

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This study aimed to analyze the effect of fall risk-increasing drugs (FRIDs) and drug-related factors relative to falls through clinical pharmacy service in hospitalized patients, focusing on the relevance of clinical pharmacist evaluation in the context of physician assessment. A prospective study of inpatient falls was conducted in 2017 retrieving data from 4 hospitals in South Bohemia, Czech Republic. An online database was developed to collect patient and fall-related data, and fall evaluation records. Healthcare professionals classified the overall effect of drugs on falls using Likert scale. Univariate and multivariate correlations were performed with a significance level of p < 0.05. Out of the total 280 falls (mean age of patients 77.0 years), a mean of 2.8 diagnoses with fall-related risk, 8.8 drugs, and 4.1 FRIDs per fall were identified. Incidence of falls decreased quarterly (p < 0.001). Use of FRIDs were positively associated with increasing age (p = 0.007). Clinical pharmacists were more likely to identify pharmacotherapy as the relevant fall-related risk, compared to physicians evaluation (p < 0.001). An increasing total number of prescribed drugs as well as higher number of FRIDs increased the suspicion in both professionals in the context of drug-related causes of falls.

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“…Use of psychotropic drugs has been identified as an independent risk factor for falls in various studies including systematic reviews and meta-analyses [10][11][12][13][14]. Yet, most of previous studies on psychotropic drug use and falls considered only some of the important health conditions associated with falls such as vision impairment [15,16], frailty [17], polypharmacy [18], use of potential fall risk-increasing drugs [12,19] and disability [20]. Results of these studies may be confounded by unmeasured factors.…”

Section: Introductionmentioning

confidence: 99%

Association of psychotropic drug use with falls among older adults in Germany. Results of the German Health Interview and Examination Survey for Adults 2008 – 2011 (DEGS1)

Wolf

Knopf

2017

Das Gesundheitswesen

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PurposeTo investigate the association of psychotropic drug use with falls among older adults in Germany based on data from the National Health Interview and Examination Survey for Adults -2011. MethodsDEGS1 collected data on drug use in the past 7 days and on falls occurred in the last 12 months. Study participants were older adults aged 65-79 years with complete data on drug use and falls (N = 1,833). Odds ratio (OR) and 95% confidence intervals (95% CI) were derived from logistic regression models adjusting for potential confounders including sociodemographic characteristics, health-related behaviors (alcohol drinking), body mass index and health conditions (frailty, vision impairment, disability, polypharmacy, blood pressure) as well as use of potential falls-risk-increasing drugs. SPSS complex sample methods were used for statistical analysis.

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The consumption of two or more fall risk‐increasing drugs rather than polypharmacy is associated with falls

Cited by 71 publications

References 32 publications

Prevalence of medication-related falls in 200 consecutive elderly patients with hip fractures: a cross-sectional study

Prevalence of medication-related falls in 200 consecutive elderly patients with hip fractures: a cross-sectional study

Pharmacotherapy as major risk factor of falls - analysis of 12 months experience in hospitals in South Bohemia

Association of psychotropic drug use with falls among older adults in Germany. Results of the German Health Interview and Examination Survey for Adults 2008 – 2011 (DEGS1)

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