Medicalized and often surveilled shifts of the cancerous and/or trans body intersect in generative ways: metaphorical and material, symbolic and systemic. This piece discusses Patrick Staff’s (2017) video Weed Killer through an analysis of its source text, Catherine Lord’s essay ‘The Summer of Her Baldness’ (2003) along with prior queer and feminist explorations of cancer, disease, and pain, to build a transfeminist analysis of how the experience of cancer treatment reveals the constructedness of femininity as well as the ablism underlying binary gender systems. Staff’s work creates alignments and ruptures between sets of a potentially intersecting politics, which bear the weight of naturalized gender, pharmacological mediation, ‘passing’, and debility.