The Content of the 14 Metals in Cancellous and Cortical Bone of the Hip Joint Affected by Osteoarthritis

Abstract

The aim of the study was to determine the content of particular elements Ca, Mg, P, Na, K, Zn, Cu, Fe, Mo, Cr, Ni, Ba, Sr, and Pb in the proximal femur bone tissue (cancellous and cortical bone) of 96 patients undergoing total hip replacement for osteoarthritis using ICP-AES and FAAS analytical techniques. The interdependencies among these elements and their correlations depended on factors including age, gender, place of residence, tobacco consumption, alcohol consumption, exposure to environmental pollution, physical activity, and type of degenerative change which were examined by statistical and chemometric methods. The factors that exerted the greatest influence on the elements in the femoral head and neck were tobacco smoking (higher Cr and Ni content in smokers), alcohol consumption (higher concentrations of Ni, Cu in people who consume alcohol), and gender (higher Cu, Zn, and Ni concentrations in men). The factors influencing Pb accumulation in bone tissue were tobacco, alcohol, gender, and age. In primary and secondary osteoarthritis of the hip, the content and interactions of elements are different (mainly those of Fe and Pb). There were no significant differences in the concentrations of elements in the femoral head and neck that could be attributed to residence or physical activity.

Impact of Varied Factors on Iron, Nickel, Molybdenum and Vanadium Concentrations in the Knee Joint

“…In our study, we observed statistically lower Fe concentration in the spongy bone of patients who consumed alcohol compared to patients who did not at 28.224 and 61.293 mg/kg dw, respectively. Zioła-Frankowska et al [53] also found lower Fe level in the cancellous bone of patients consuming alcohol; however the difference was not statistically significant.…”

“…Knowledge of these relationships is important for the understanding of kinetic interactions of elements in the body [66]. Zioła-Frankowska et al [53] did not observed a correlation between Ni-Mo, Ni-Fe, and Fe-Mo in the femoral neck and head, whereas Dąbrowski et al [45] noted significantly positive Fe/Ni interaction in the bone. This research is the first to find a correlation among elements in the structures of the knee joint: Fe SB -Fe ACL , Fe SB -Ni SB…”

“…Roczniak et al [4], investigating the residence of the same area as Brodziak-Dopierała et al [20,51], observed much lower Ni concentrations in the tibia, femur, and meniscus at 0.52, 0.60, and 0.85 mg/kg dw, respectively. Zioła-Frankowska et al [53], in patents from Wielkopolska (Poland), noted that Ni concentrations were 0.6 mg/kg dw in the femoral head and 0.79 mg/kg dw in the femoral neck. Łanocha-Arendarczyk et al [54] found even lower Ni concentrations in the cartilage and spongy bone of the hip joint at 0.206 and 0.379 mg/kg dw, respectively.…”

“…Kubaszewki et al [55] found a higher Mo concentration in the bone, ranging from 0.36 to 1.9 mg/kg dw. Zioła-Frankowska et al [53] observed that the median Mo concentration in the femoral head and neck was 0.18 mg/kg dw. In our study, we noted higher Mo concentrations in the spongy bone of the knee joint, ranging 0.021 to 2.377 mg/kg dw, with a mean value of 0.935 mg/kg dw.…”

“…Moreover, ethanol can have a modulating effect through mineral regulating hormones such as vitamin D metabolites, parathyroid hormone, and calcitonin [62,63]. Zioła-Frankowska et al [53] found statistically significant differences between Mo and Ni concentrations in the cancellous bone of the hip joint according to alcohol consumption. They observed higher Ni and lower Mo concentrations in the spongy bone of patients who consumed alcohol compared to abstainers.…”