The Contribution of Bronchoalveolar Lavage Performed Before and After Bronchoscopic Biopsies to the Diagnosis of Peripheral Lung Cancer

Tatar, Dursun

doi:10.4999/uhod.09098

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…Similar male preponderance of bronchial carcinoma were reported in several other studies. 3,23,28,29 Male-Female ratio in this study is markedly increased which can be explained by some reasons like small sample size, less reporting of female patients in a tertiary care hospital and less common smoking habit in female in our country.…”

Section: Discussionmentioning

confidence: 89%

Role of Bronchial Brush Cytology in Diagnosis of Central Bronchial Carcinoma

Sultana

Patwary

Rahman

et al. 2017

J. Bangladesh Coll. Phys.

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Background : Despite the advances in imaging techniques and treatment modalities, the prognosis of lung cancer remains poor, with five-year survival of 14% at early stages and less than 5% in locally advanced stages. Before starting treatment a clear distinction between small cell and nonsmall cell carcinoma must be made, for that histopathology remains the mainstay of confirmation of diagnosis. To combat the disease successfully, it should be diagnosed at earliest possible stage. If bronchial brush cytology yield comparable diagnostic specificity, then it may easy for the patient and physician to manage this fatal disease.

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Section: Discussionmentioning

confidence: 89%

Role of Bronchial Brush Cytology in Diagnosis of Central Bronchial Carcinoma

Sultana

Patwary

Rahman

et al. 2017

J. Bangladesh Coll. Phys.

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“…This is similar to Tartar et al who found BAL cytology alone diagnostic for one case in his study. 5 The reason for negative FNA may be inappropriate localization of lesion during FNA procedure.…”

Section: Resultsmentioning

confidence: 99%

Correlation of Fine Needle Aspiration Cytology With Bronchoalveolar Lavage and Brush Smear Cytology in Pulmonary Lesions

Rohtagi¹,

Khan²,

Pantola³

et al. 2014

jemds

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BACKGROUND: Fine Needle Aspiration Cytology (FNAC), Bronchoalveolar Lavage (BAL) and Brush Cytology are important diagnostic tools for evaluation of pulmonary lesions. Considering the limitations of these procedures correlation of these cytological techniques may help in improving accuracy and increasing the diagnostic yield. AIM: To determine the role of FNAC, Brush and BAL Cytology in pulmonary lesions and to correlate the efficacy of FNAC with Brush and BAL Cytology. MATERIALS AND METHODS:This prospective study was conducted on 78 patients with radiologically demonstrable pulmonary lesions in the department of pathology and Dr ML Chest Hospital, GSVM Medical College, Kanpur over a period from nov2011-july2013. The cases selected had to give consent for the procedure. Bronchoalveolar lavage, bronchial brush sample were taken and FNAC was done in the cases. RESULTS: In present study 78 cases of pulmonary lesions were subjected to FNAC and/ or Bronchoalveolar lavage and brush cytology. Among them 49 cases were selected in which all three procedures were done. The sensitivity and specificity for detecting lung tumors by FNAC was 96.29% and 95.45% which was more than that of BAL cytology (84.61%, 91.30%) and Brush cytology (81.48%, 95.45%). FNA correlates with Brush and BAL cytology in 78.57% of malignant lesions. Among malignant lesions 84.61% of BAL and Brush cytology correlates with FNA for diagnosis of squamous cell carcinoma. FNA correlates with 66.67% of brush and 83.37% of BAL fluid cytology for diagnosis of adenocarcinoma. BAL and Brush both correlates with FNA in 83.33% cases of small cell carcinoma. Overall 85.71% of BAL and 82.14% of brush smear cytology correlates with FNA cytology for diagnosis of lung cancers. CONCLUSIONS: FNA, BAL and Brush cytology provide a high yield for evaluation of pulmonary lesions. BAL fluid and brush cytology correlated well with FNAC for diagnosis of lung cancers.

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“…from all 30 patients with primary lung cancer only one patient had positive sputum cytology. [ 6 ] Our study also showed that this technique is only occasionally used in the diagnosing process and it is the right approach because of their low diagnostic rate.…”

Section: Discussionmentioning

confidence: 65%

Lung cancer cytology: Can any of the cytological methods replace histopathology?

Chrabańska

Środa

Kiczmer

et al. 2020

J Cytol

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Background: Diagnosis of lung cancer can be made in two ways: histopathological and cytopathological. Cytological methods in the diagnosis of lung lesions are generally thought to be one of the most successful tactics. Aims: This study aimed at comparing the efficiency of selected cytological techniques in lung lesions by correlating them with histopathological diagnosis. In addition, we had answered the question whether any of the cytological methods can replace histopathology. Materials and Methods: The study group consisted of 633 patients and 1085 cytological specimens. Cytology samples included: induced sputum, bronchial washing (BW), bronchial brushing (BB), fine needle aspiration (FNA), and cell block (CB). In every case of CB immunocytochemistry (ICC) was performed. For each cytological method sensitivity, specificity, effectiveness, positive predictive value, and negative predictive value were assessed. Results: BW and BB showed the lowest diagnostic parameters. The most valuable diagnostic procedure was CB based on FNA. Close by CB, FNA had the highest diagnostic rate. However, possibility to evaluate tumor cell structure and apply the ICC, give CB an advantage over FNA. Using only morphologic criteria, we had subclassified nonsmall-cell lung cancer (NSCLC) into squamous cell carcinoma (SCC) and adenocarcinoma (AC) as 60.04% of SCC and 32.52% of AC. The use of CB and ICC decreased the NSCLC diagnoses from 22.1% to 2.8% while the percentage of AC and SCC diagnoses increased from 4.11% to 12.64% and from 6.64% to 11.06%, respectively. Metastatic lung tumors were diagnosed based on both the cell morphology and according to the ICC results. Conclusion: Despite the limitations of the cytological procedures, we recommend using CB and ICC to evaluate cytological samples derived from FNA. It can in many cases replace a conventional histopathology.

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The Contribution of Bronchoalveolar Lavage Performed Before and After Bronchoscopic Biopsies to the Diagnosis of Peripheral Lung Cancer

Cited by 3 publications

References 18 publications

Role of Bronchial Brush Cytology in Diagnosis of Central Bronchial Carcinoma

Role of Bronchial Brush Cytology in Diagnosis of Central Bronchial Carcinoma

Correlation of Fine Needle Aspiration Cytology With Bronchoalveolar Lavage and Brush Smear Cytology in Pulmonary Lesions

Lung cancer cytology: Can any of the cytological methods replace histopathology?

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