The Contribution of Endogenous and Exogenous Factors to Female Alopecia

Gatherwright, James; Liu, Mengyuan; Gliniak, Christy; Totonchi, Ali; Guyuron, Bahman

doi:10.1097/prs.0b013e31826d104f

Cited by 24 publications

(20 citation statements)

References 42 publications

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“…One limitation of this study is that AGA may be affected by many genes that have not yet been identified; twin studies have shown that the AGA condition is heritable, and a family history of AGA has been included in our analysis for this reason. However, there are still many findings [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82], [83], [84], [85], [86], [87], [88] that suggest that heritable and epigenetic [69], [89] differences also play a role in alopecia; this may replace the classical discussion of the roles of genetic and environmental factors in alopecia.…”

Section: Discussionmentioning

confidence: 99%

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Androgenic Alopecia Is Associated with Less Dietary Soy, Higher Blood Vanadium and rs1160312 1 Polymorphism in Taiwanese Communities

et al. 2013

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BackgroundAlthough the genetic basis of androgenic alopecia has been clearly established, little is known about its non-genetic causes, such as environmental and lifestyle factors.ObjectiveThis study investigated blood and urine heavy metals concentrations, environmental exposure factors, personal behaviors, dietary intakes and the genotypes of related susceptibility genes in patients with androgenic alopecia (AGA).DesignAge, AGA level, residence area, work hours, sleep patterns, cigarette usage, alcohol consumption, betel nut usage, hair treatments, eating habits, body heavy metals concentrations and rs1998076, rs913063, rs1160312 and rs201571 SNP genotype data were collected from 354 men. Logistic regression analysis was performed to examine whether any of the factors displayed odds ratios (ORs) indicating association with moderate to severe AGA (≧IV). Subsequently, Hosmer-Lemeshow, Nagelkerke R2 and accuracy tests were conducted to help establish an optimal model.ResultsModerate to severe AGA was associated with the AA genotype of rs1160312 (22.50, 95% CI 3.99–126.83), blood vanadium concentration (0.02, 95% CI 0.01–0.04), and regular consumption of soy bean drinks (0.23, 95% CI 0.06–0.85), after adjustment for age. The results were corroborated by the Hosmer-Lemeshow test (P = 0.73), Nagelkerke R2 (0.59), accuracy test (0.816) and area under the curve (AUC; 0.90, 0.847–0.951) analysis.ConclusionsBlood vanadium and frequent soy bean drink consumption may provide protect effects against AGA. Accordingly, blood vanadium concentrations, the AA genotype of rs1160312 and frequent consumption of soy bean drinks are associated with AGA.

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Section: Discussionmentioning

confidence: 99%

“…The cross-sectional nature of the measurements of blood metals and personal behaviors (for example, sleep patterns [67], [68], [70], [94] and oily scalp [62], [95], [96], [97], [98], [99], [100]) limit our ability to identify causal relationships; the time of onset of moderate to severe hair loss will need more investigation in future work.…”

Section: Discussionmentioning

confidence: 99%

Androgenic Alopecia Is Associated with Less Dietary Soy, Higher Blood Vanadium and rs1160312 1 Polymorphism in Taiwanese Communities

et al. 2013

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“…Although the data are limited, hair loss has also been associated with stressful conditions in both human and non‐human primates. For example, hairline recession and thinning in women was associated with having experienced a higher severity of stress and number of lifetime stressors . Similarly, patients with alopecia areata (AA), a dermatological condition that is associated with the sudden loss of hair from discrete areas, experienced a greater number of stressful life events, such as the loss of a family member, than did those without AA .…”

Section: Introductionmentioning

confidence: 99%

Alopecia in rhesus macaques (Macaca mulatta): Association with pregnancy and chronic stress

Lutz

Menard

Rosenberg

et al. 2019

J of Medical Primatology

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Background Alopecia in captive non‐human primates is often presented as a welfare issue. However, it is a complex condition with a number of possible causes. The purpose of this study was to assess the impact of pregnancy and hair cortisol concentrations on alopecia in rhesus macaques. Methods Subjects were 113 socially housed adult female rhesus macaques (27 pregnant, 35 nursing infants, 51 controls). During routine physicals, photographs were taken for alopecia assessment and hair samples were collected for cortisol assay. Results Alopecia was more prevalent in pregnant than in control females, but there was no association between alopecia and hair cortisol. However, there was a significant effect of pregnancy on hair cortisol. Nursing females had higher hair cortisol levels than pregnant females, which had higher levels than control females. Conclusions Although alopecia does not appear to be associated with hair cortisol, both alopecia and hair cortisol were associated with pregnancy.

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“…Gatherwright et al [68] compared 98 monozygotic female twins to identify possible environmental factors that may contribute toward AGA. Gatherwright et al [68] compared 98 monozygotic female twins to identify possible environmental factors that may contribute toward AGA.…”

Section: Associations and Comorbiditiesmentioning

confidence: 99%

Androgenetic alopecia

Kabir¹,

Goh²

2013

Journal of the Egyptian Womenʼs Dermatologic Society

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Androgenetic alopecia (AGA) and female pattern hair loss are highly prevalent in our society. In recent years, many strides have been made in understanding the epidemiology and the pathophysiology of this disease; yet, there are few truly effective treatments. In this paper, we review some of the recent research on the epidemiology, pathophysiology, and treatment of AGA. Further studies on genetics, mechanisms of disease, and novel therapies will likely lead to more efficacious treatment and improved outcomes in patients who have AGA and female pattern hair loss.

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The Contribution of Endogenous and Exogenous Factors to Female Alopecia

Abstract: This study implicates several environmental risk factors in the pathophysiology of female alopecia.

Cited by 24 publications

References 42 publications

Androgenic Alopecia Is Associated with Less Dietary Soy, Higher Blood Vanadium and rs1160312 1 Polymorphism in Taiwanese Communities

Androgenic Alopecia Is Associated with Less Dietary Soy, Higher Blood Vanadium and rs1160312 1 Polymorphism in Taiwanese Communities

Alopecia in rhesus macaques (Macaca mulatta): Association with pregnancy and chronic stress

Androgenetic alopecia

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